Two experimental drug molecules promoted myelin repair in MS disease models, pointing toward a possible future route for treating nerve damage rather than only suppressing inflammation.
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Long Non-Coding RNAs (lncRNAs) in Heart Failure: A Comprehensive Review
Heart failure (HF) is a widespread cardiovascular condition that poses significant risks to a wide spectrum of age groups and leads to terminal illness. Although our understanding of the underlying mechanisms of HF has improved, the available treatments still remain inadequate. Recently, long non-coding RNAs (lncRNAs) have emerged as crucial players in cardiac function, showing possibilities as potential targets for HF therapy. These versatile molecules interact with chromatin, proteins, RNA, and DNA, influencing gene regulation. Notable lncRNAs like Fendrr, Trpm3, and Scarb2 have demonstrated therapeutic potential in HF cases.
How Rockstar Fit Liberty City Into PS2’s Tiny Memory
Mark Brown from Game Maker’s Toolkit released a new video.
Clock Town Recreated Inside Perfect Dark By Dedicated Modder
Something you might have dreamed about 20 years ago.
World’s largest ever survey of physicists, results & reaction
What do physicists really think about the biggest mysteries in the universe?
In this video, leading voices in theoretical physics come together to unpack the results of the Big Mystery Survey—the largest survey ever conducted of professional physicists, prepared in collaboration with the American Physical Society’s Physics Magazine.\.
Human vs. Machine Consciousness | Imperial’s Murray Shanahan
An interview with Murray Shanahan on philosophy and AI consciousness.
For more on how you can get involved with Cosmos including roles we are hiring for & how to receive our grants, visit: https://johnathanbi.com/cosmos.
You can read the full transcript here: https://www.johnathanbi.com/p/transcript-for-interview-with-…ahan-on-ai.
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Further Reading:
Professor Shanahan’s book on Consciousness: https://amzn.to/42rdsT0 (affiliate)
Timestamps:
Brain histamine map connects genes to brain function and mental health
New research from King’s College London and the University of Porto has mapped the histamine system in the brain. Histamine, a molecule more commonly associated with allergies, plays a separate but poorly understood role in brain function. This study addresses this gap, building the first multiscale map of the histamine system that spans from genetics to behavior and related mental health conditions.
The findings provide a new framework for understanding how this often-overlooked chemical system contributes to brain function and could point toward new treatment strategies for histamine-related conditions such as depression, ADHD, and schizophrenia. The study is published in Nature Mental Health.
Histamine is a neurotransmitter, a molecule crucial for neurons to communicate with one another. Neuroscience research has classically focused on understanding other neurotransmitter systems such as dopamine and serotonin.
Between ego and faith: Motivational, affective, and cognitive dimensions of religious engagement in narcissism
At first glance, narcissism and religion seem like an unlikely pair. Religious traditions usually promote humility, selflessness, and community care. Narcissism is a personality trait characterized by egotism, a sense of superiority, and a strong feeling of entitlement. This stark contrast raises an interesting question about how individuals with strong narcissistic traits interact with religious beliefs and communities.
Previous studies looking at broad connections between narcissism and religion have yielded mixed results. Some research suggests religious individuals actually score higher on general narcissism scales than non-religious people. Other sets of data show no significant relationship at all between grandiose narcissism and a person’s overall level of faith. To make sense of these apparent contradictions, researchers decided to break down both narcissism and religiosity into more specific categories.
“What drew my attention was that although research on trait narcissism has been growing rapidly, we still know relatively little about how it relates to religiosity,” said study author Julia Tokarz, a doctoral candidate at the University of Warsaw’s Faculty of Psychology and a member of the Personality Intelligence Cognition Lab. “Previous studies were quite limited and did not take into account the current three-factor model of narcissism.”
Abstract.
Although the link between narcissism and religiosity appears to be ambiguous, a more nuanced approach to both constructs may reveal specific patterns. This research aimed to explore links between different dimensions of narcissism and various aspects of religiosity. Study 1 revealed that all facets of narcissism (agentic, antagonistic, neurotic, communal) were associated with extrinsic religious orientation, indicating an overall stronger desire to engage in religious practices driven by instrumental motives. In the second study, agentic and antagonistic narcissism were related to a punitive God’s image, whereas the antagonistic facet was also inversely related to positive religious coping, loving God image, and general religiosity. In the third study, divine entitlement (i.e.