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A World Where Anyone Who Needs a Bone Marrow Transplant Gets One — Kevin Caldwell — Ossium Health

Imagine a world where anyone who needs a bone marrow transplant can get one — on demand. No more desperate donor searches or deadly delays. Kevin Caldwell, Co-Founder & CEO, Ossium Health.

Bone marrow transplants have always depended on finding the right donor at the right time. But what if bone marrow could be stored, shipped, and used on demand—just like a drug? That’s exactly what Ossium Health is now showing in human clinical data.

Kevin Caldwell is the Co-Founder, CEO, and President of Ossium Health (https://ossiumhealth.com/), a clinical-stage bioengineering company pioneering off-the-shelf, cryopreserved bone marrow therapies derived from deceased organ donors.

Under Kevin’s leadership, Ossium has developed a novel platform designed to solve one of the most persistent challenges in transplantation medicine: timely access to compatible bone marrow for patients with life-threatening hematologic malignancies such as Acute Myeloid Leukemia. The company’s approach enables on-demand delivery of viable marrow cells, bypassing the logistical and biological constraints of traditional donor matching and scheduling.

Since its founding, Kevin has scaled Ossium from an early-stage startup into a clinical-stage company with a robust network of over 50 strategic partnerships across supply, clinical development, and commercial channels. He has led multiple financings and secured a landmark contract with the Biomedical Advanced Research and Development Authority, validating Ossium’s relevance to national health preparedness and biomanufacturing resilience.

Continue reading “A World Where Anyone Who Needs a Bone Marrow Transplant Gets One — Kevin Caldwell — Ossium Health” | >

Forgotten FPS sequel Heretic 2 gets a ‘reverse-engineered sourceport’ that fixes bugs, improves the framerate and adds ‘lots of cosmetic improvements’

Dubbed Heretic2R, the sourceport introduces a bunch of new technical features to the elf wizard Corvus’ second adventure. For starters, it adds widescreen support with automatic HUD scaling, and unlocks the framerate to a theoretical maximum of 1,000 FPS.

On top of this, Heretic 2R ensures that in-game special effects update at the appropriate rendering framerate, improves map loading times, and makes “lots of cosmetic improvements” so that “the game plays as you remember it, not as it actually played”. Which sounds very remaster-y to me.

Holographic storage approach packs more data into the same space by encoding three properties of light

Researchers have developed a holographic data storage approach that stores and retrieves information in three dimensions by combining three properties of light—amplitude, phase and polarization. By allowing more data to be stored in the same space, the new approach could help advance efforts to meet the growing global demand for data storage.

Holographic data storage uses laser light to store digital information inside a material. Instead of recording data only on a surface, like a hard drive or optical disk, it stores many overlapping light patterns throughout the volume of the material, allowing much higher storage density and faster data transmission.

“In conventional holographic data storage, data encoding typically uses one light dimension such as amplitude or phase alone, or, at most, combines two of these dimensions,” said research team leader Xiaodi Tan from Fujian Normal University in China.

14 JEPA Milestones as a Map of AI Progress

Tx, Yann LeCun.

• JEPA / H-JEPA: avoids predicting every single pixel (too expensive) and rather predicts in latent space. H-JEPA adds hierarchy — short term details vs long term planning ie. how humans actually learn.

• I-JEPA: built for very efficient vision models. Masks image patches and predicts the semantics and in doing so bypasses heavy compute of traditional autoencoders.

• MC-JEPA & V-JEPA: both of these are built for videos. MC-JEPA separates content (what an object is) vs motion (how it moves). V-JEPA masks video features with no text labels making it perfect of action tracking at scale.

• Audio-JEPA: filters out background noise by treating sounds like visuals.

• Point-JEPA & 3D-JEPA: used primarily in AVs. Uses LiDAR point clouds & volumetric grids.

• ACT-JEPA: filters out real world noise to learn manipulation tasks efficiently via imitation learning.

Continue reading “14 JEPA Milestones as a Map of AI Progress” | >

Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis

Linking epigenetics and metabolism in neurogenesis!

Epigenetic regulation and metabolism are tightly coordinated during progenitor cell growth but the processes linking this crosstalk is not well understood.

The researchers examined in neural stem cells the role of PHF8, a histone demethylase whose mutations are linked to Siderius-Hamel syndrome, a rare neurodevelopmental disorder.

The authors show that PHF8 regulates neural progenitor proliferation by coordinating epigenetic and metabolic programs and drives serine biosynthesis by maintaining chromatin accessibility of serine synthesis genes.

They also demonstrate that loss of PHF8 disrupts metabolism, autophagy, and vesicle formation and its deficiency leads to DNA damage and halts neurogenesis in vivo. sciencenewshighlights ScienceMission https://sciencemission.com/Epigenetic-regulation-of-serine-biosynthesis

Progenitor proliferation during neurodevelopment requires tight coordination of epigenetic regulation and metabolism. However, the crosstalk between these processes remains poorly understood. To investigate this, we examine in neural stem cells the role of PHF8, a histone demethylase whose mutations are linked to Siderius-Hamel syndrome, a rare neurodevelopmental disorder. Through an integrated multi-omics approach — combining transcriptomics, epigenomics, and metabolomics — we identify PHF8 as a key driver of the serine biosynthesis pathway, safeguarding the intracellular serine pool essential for neural progenitor proliferation. PHF8 fine-tunes chromatin accessibility at promoters of metabolic genes, ensuring their activation during development. Loss of PHF8 disrupts amino acid metabolism, blocks autophagy, and hinders vesicle formation.

Continue reading “Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis” | >

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