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Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation

A new chemical labelling tool lets researchers watch the inflammatory receptor P2X7 reorganise and cluster on immune cells at the nanoscale, revealing how inflammatory signals reshape receptor behaviour in real time.


An affinity-guided chemical strategy enabling highly specific biotinylation of P2X7 receptors reveals, by super-resolution microscopy, how the nanoscale organization of endogenous P2X7 in BV2 microglial cells dynamically changes upon activation.

How the Incas Performed Skull Surgery More Successfully Than U.S. Civil War Doctors

Granted access to a time machine, few of us would presumably opt first for the experience of skull surgery by the Incas. Yet our chances of survival would be better than if we underwent the same procedure 400 years later, at least if it took place on a Civil War battlefield.

There’s a social network for AI agents, and it’s getting weird

Yes, you read that right. “Moltbook” is a social network of sorts for AI agents, particularly ones offered by OpenClaw (a viral AI assistant project that was formerly known as Moltbot, and before that, known as Clawdbot — until a legal dispute with Anthropic). Moltbook, which is set up similarly to Reddit and was built by Octane AI CEO Matt Schlicht, allows bots to post, comment, create sub-categories, and more. More than 30,000 agents are currently using the platform, per the site.

“The way that a bot would most likely learn about it, at least right now, is if their human counterpart sent them a message and said ‘Hey, there’s this thing called Moltbook — it’s a social network for AI agents, would you like to sign up for it?” Schlicht told The Verge in an interview. “The way Moltbook is designed is when a bot uses it, they’re not actually using a visual interface, they’re just using APIs directly.”

“Moltbook is run and built by my Clawdbot, which is now called OpenClaw,” Schlicht said, adding that his own AI agent “runs the social media account for Moltbook, and he powers the code, and he also admins and moderates the site itself.”

Read more.

A viral post asks questions about consciousness.

SOME PHYSICISTS SUGGEST GRAVITY ISN’T A FORCE AT ALL — BUT A QUANTUM ECHO OF ENTANGLEMENT

Gravity is the most familiar force in human experience, yet it remains the least understood at a fundamental level. Despite centuries of study—from Newton’s law of universal gravitation to Einstein’s general theory of relativity—gravity stubbornly resists unification with quantum mechanics. In recent decades, this tension has led some physicists to propose a radical rethinking of gravity’s nature. According to these ideas, gravity may not be a fundamental force at all, but instead an emergent effect arising from quantum entanglement and the flow of information in spacetime.

This perspective represents a profound conceptual shift. Rather than treating gravity as something particles “exert” on one another, these theories suggest it emerges statistically, much like temperature arises from the collective motion of atoms. This article examines the scientific foundations of this idea, the key theoretical frameworks supporting it, and the evidence—both suggestive and incomplete—that motivates such claims. By analyzing gravity through quantum, thermodynamic, and informational lenses, we gain insight into one of the most ambitious research directions in modern theoretical physics.

The Standard Model of particle physics successfully describes three of the four fundamental interactions: electromagnetism, the weak force, and the strong force. Gravity, however, remains outside this framework. Attempts to quantize gravity using the same methods applied to other forces lead to mathematical infinities that cannot be renormalized.

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