What would happen if we created something far smarter than humans?

The story behind the writing of Frankenstein is famous. In 1816, Mary Shelley and Percy Bysshe Shelley, summering near Lake Geneva in Switzerland, were challenged by Lord Byron to take part in a competition to write a frightening tale. Mary, only 18 years old, later had a waking dream of sorts where she imagined the premise of her book:

When I placed my head on my pillow, I did not sleep, nor could I be said to think. My imagination, unbidden, possessed and guided me, gifting the successive images that arose in my mind with a vividness far beyond the usual bounds of reverie. I saw — with shut eyes, but acute mental vision, — I saw the pale student of unhallowed arts kneeling beside the thing he had put together. I saw the hideous phantasm of a man stretched out, and then, on the working of some powerful engine, show signs of life, and stir with an uneasy, half vital motion.

This became the kernel of Frankenstein; or, The Modern Prometheus, the novel first published in London in 1818, with only 500 copies put in circulation.

All human experience is rooted in the brain, but we just barely understand how it works. That’s partially because it’s hard to study: Scientists can’t just run experiments on living brains, and experiments on animal brains don’t always translate to humans. That’s why researchers developed the brain organoid, an artificially grown, three-dimensional cluster of human neurons that faithfully mimics brain development — and, as Japanese scientists reported Wednesday in Cell Stem Cell, the neural activity of a living brain as well.

Neurons in a living brain respond to stimuli by “firing” off electrical impulses, which they use to communicate with one another and with other parts of the body. The scientists behind the new paper discovered that the brain organoids they grew from scratch in their lab also started to exhibit synchronized activity, just like neurons in an actual brain. That team included first and co-corresponding author Hideya Sakaguchi, Ph.D., a postdoctoral fellow at Kyoto University currently at the Salk Institute.

“I was very excited to see some of the neurons activated at the same time robustly at first,” Sakaguchi, who did the first of his experiments in December 2016, tells Inverse. “Neurons first show individual activities, but as they form networks and connections between other neurons, they start to show synchronized activities.”

DMT, an active compound of the psychedelic Ayahuasca, is naturally occurring in the mammalian brain, researchers have discovered. The study revealed DMT levels increased significantly in the rat visual cortex following cardiac arrest.