Alzheimer’s disease is a neurodegenerative disease characterized by a progressive decline in mental functions and memory loss. Along with frontotemporal dementia and some other neurodegenerative disorders, Alzheimer’s disease has been associated with an accumulation inside neurons of abnormal clumps of a protein called “tau.”
The tau protein is important for brain health, stabilizing structures called microtubules inside neurons. In Alzheimer’s disease and other tauopathies (i.e., diseases linked with the abnormal accumulation of tau), tau proteins aggregate into toxic and insoluble clumps that are harmful to brain cells, gradually leading to their death.
Researchers at Zhejiang University, Xiamen University and other institutes in China recently carried out a study aimed at better understanding the processes via which tau aggregation contributes to the death of neurons in patients with Alzheimer’s disease. Their findings, published in Nature Neuroscience, suggest that these tau clumps prompt the reactivation of transposable DNA elements in neurons, which can in turn lead to their death.
Researchers at the University of Cambridge have provided the first-ever proof that human nerve regeneration after an injury can be reversed and reactivated. Using stem cell-derived brain and spinal cord organoids, scientists discovered a specific genetic network that acts like a “switch,” shutting down axon growth as neurons mature. Remarkably, by blocking key regulators within this network using an already available human drug called lynestrenol, they successfully retriggered the growth of nerve fibers. While lynestrenol itself is not an immediate cure for spinal cord injuries, this monumental discovery proves that the physiological barrier preventing nerve regeneration can be overcome — opening up incredible new possibilities for reversing paralysis and treating severe neurodegenerative diseases in the future!
Cambridge scientists have grown miniature circuits in the lab that mimic how the brain and spinal cord connect up, which underlies our movements. They used this model to show how damage to these connections previously considered ‘irreversible’ could, in fact, be reversible.
Our sophisticated organoid models help bridge the knowledge gap from animal models to what we see in patients.
Because the brain and spinal cord are separate but connected structures in the body, the team kept the organoids physically apart in the lab. They then observed axons from the brain tissue growing across the gap and connecting with the spinal cord tissue. The resulting neural circuit was functional enough to trigger contractions in tiny clusters of muscle cells.
Nerve Regrowth Declines During Development
The scientists maintained these miniature systems in the lab for more than a year. They discovered that until about day 150 of development, roughly corresponding to the middle stage of pregnancy, damaged axons could still regrow. After that point, the neurons showed a major decline in their ability to regenerate.
A feature story authored by Simon Spichak, MSc investigates how biotech companies like Cortical Labs and FinalSpark harness human brain cells to electrodes, performing computational functions and testing the cells’ responses to electrical and chemical stimuli. To create biocomputers, scientists grow organoids—small spheres of, in this case, neural tissue—on top of multi-electrode arrays in a hardware shell, which can then be used for everything from testing medications to playing video games. The work is published in the Journal of Medical Internet Research.
A compound in aged garlic extract may help reduce age-related muscle decline by activating anti-aging pathways connecting fat tissue, the brain, and muscles.
Roger Penrose and Brian Cox discuss how Roger got interested in physics, the Big Bang, and the role of beauty in mathematics.
Do you agree with Roger’s thoughts on string theory?
With a free trial, you can watch the full conversation NOW at https://iai.tv/video/our-future-theor… the Big Bang to the fabric of spacetime and the nature of consciousness, our core scientific assumptions frame how we understand and perceive reality. But there are many challenges to our current understanding. What if the very foundations of our theories are flawed? Should we reconsider our understanding? And how radically might our view of the universe have to change? Join Roger Penrose, Nobel Prize Laureate and winner of the Wolf prize, in collaboration with Stephen Hawking, with legendary physicist and science communicator, Brian Cox, to explore whether the flaws in our current theories are at some fundamental level insurmountable, or whether they can be extended or changed to overcome these challenges. #physics #cosmology #bigbang Awarded the 2020 Nobel Prize in Physics for his work on black holes, Roger Penrose is a world-renowned mathematician and physicist. In recent years, he has investigated the relationship between physics and the mind, famously arguing that quantum mechanics plays an essential role in solving the mysteries of human consciousness. Penrose has made numerous appearances on media such as BBC, Closer to Truth, and The Joe Rogan Experience. In 1994, he was knighted for his services to science. Famed for his poetic take on the cosmos, physicist and broadcaster Brian Cox has become one of the world’s most recognizable voices in science communication. A former musician turned particle physicist, Cox has played a key role in major experiments at CERN and the Large Hadron Collider, while also captivating millions through BBC series such as Wonders of the Universe, The Planets, and Forces of Nature. Cox has been showered with praise for his contributions, appointed Commander of the Order of the British Empire (CBE), and is the recipient of the Institute of Physics Kelvin Medal and the Michael Faraday Prize. Beyond his work as a Royal Society professor of physics at the University of Manchester, Cox advocates for public scientific literacy and political responsibility in science funding. His style blends rigorous physics with a deep sense of awe — bringing relativity, entropy, and quantum theory into living rooms around the globe. His rare ability to fuse clarity with wonder has earned global acclaim. The Institute of Art and Ideas features videos and articles from cutting edge thinkers discussing the ideas that are shaping the world, from metaphysics to string theory, technology to democracy, aesthetics to genetics. Subscribe today! https://iai.tv/subscribe?utm_source=Y… 0:00 Intro 0:44 Brian Cox on how Roger Penrose inspired him 1:39 — Beauty in mathematics 3:00 — How Roger struggled with maths at school 6:51 — How Roger got interested in physics 9:27 — What theory is best for explaining the beginning of the universe? 12:12 — A key new discovery in cosmology 18:44 — The big bang is not quantum mechanical For debates and talks: https://iai.tv For articles: https://iai.tv/articles For courses: https://iai.tv/iai-academy/courses.
From the Big Bang to the fabric of spacetime and the nature of consciousness, our core scientific assumptions frame how we understand and perceive reality. But there are many challenges to our current understanding. What if the very foundations of our theories are flawed? Should we reconsider our understanding? And how radically might our view of the universe have to change? Join Roger Penrose, Nobel Prize Laureate and winner of the Wolf prize, in collaboration with Stephen Hawking, with legendary physicist and science communicator, Brian Cox, to explore whether the flaws in our current theories are at some fundamental level insurmountable, or whether they can be extended or changed to overcome these challenges.
#physics #cosmology #bigbang.
Awarded the 2020 Nobel Prize in Physics for his work on black holes, Roger Penrose is a world-renowned mathematician and physicist. In recent years, he has investigated the relationship between physics and the mind, famously arguing that quantum mechanics plays an essential role in solving the mysteries of human consciousness.
