Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience – Page 72

Scientists looking to tackle our ongoing obesity crisis have made an important discovery: Intermittent calorie restriction leads to significant changes both in the gut and the brain, which may open up new options for maintaining a healthy weight.

Researchers from China studied 25 volunteers classed as obese over a period of 62 days, during which they took part in an intermittent energy restriction (IER) program – a regime that involves careful control of calorie intake and relative fasting on some days.

Not only did the participants in the study lose weight – 7.6 kilograms (16.8 pounds) or 7.8 percent of their body weight on average – there was also evidence of shifts in the activity of obesity-related regions of the brain, and in the make-up of gut bacteria.

Read more | >

For a very long time, we have been under the impression that memory and learning are solely the brain’s forte. Central to this belief is the fact that our brains, particularly our brain cells, store memories.

However, an innovative team of researchers begs to differ, suggesting that cells in other parts of the body partake in this memory function too.

The ability of non-brain cells to learn and form memories is a riveting discovery.

Read more | >

Model mice treated with extracts and powders exhibit restored cognitive and motor functions. Efforts to develop a breakthrough dementia drug are gaining attention, yet traditional medicinal products may provide valuable insights for preventive care. A research group led by Specially Appointed Professor Takami Tomiyama of Osaka Metropolitan University’s Graduate School…

Read more | >

A study found that male worms’ brains can activate conflicting memories, but behavior is driven by the more beneficial one. This research sheds light on how brains prioritize information, offering insights into conditions like PTSD.

A new study by UCL researchers reveals that two conflicting memories can simultaneously be activated in a worm’s brain, even though only one memory directly influences the animal’s behavior.

In the paper published in Current Biology, the researchers showed how an animal’s sex drive can at times outweigh the need to eat when determining behavior, as they investigated what happens when a worm smells an odor that has been linked to both good experiences (mating) and bad experiences (starvation).

Read more | >

The recipient of the world’s first Neuralink brain-chip transplant is able to control a computer mouse by thinking, the tech startup’s founder Elon Musk announced this week.

“Progress is good, and the patient seems to have made a full recovery, with no ill effects that we are aware of,” Reuters reported that Musk said in an X Spaces event on Monday. “Patient is able to move a mouse around the screen by just thinking.”

Musk added that Neuralink was trying to get the patient to click the mouse as much as possible, Reuters reported.

Read more | >

Tissues take shape during development through a series of morphogenetic movements guided by local cell-scale forces. While current in vitro approaches subjecting tissues to homogenous stresses, it is currently no possible to recapitulate highly local spatially varying forces. Here we develop a method for local actuation of organoids using embedded magnetic nanoparticles. Sequential aggregation of magnetically labelled human pluripotent stem cells followed by actuation by a magnetic field produces localized magnetic clusters within the organoid. These clusters impose local mechanical forces on the surrounding tissue in response to applied global magnetic fields. We show that precise, spatially defined actuation provides short-term mechanical tissue perturbations as well as long-term cytoskeleton remodeling. We demonstrate that local magnetically-driven actuation guides asymmetric growth and proliferation, leading to enhanced patterning in human neural organoids. We show that this approach is applicable to other model systems by observing polarized patterning in paraxial mesoderm organoids upon local magnetic actuation. This versatile approach allows for local, controllable mechanical actuation in multicellular constructs, and is widely applicable to interrogate the role of local mechanotransduction in developmental and disease model systems.

The authors have declared no competing interest.

Read more | >

Sometimes there are slightly different versions, or sequences of genes. There are several versions of the apolipoprotein E (APOE) gene, for example. One of them, called APOE4, has been linked to a much higher risk of developing Alzheimer’s disease, and carriers often have worse forms of the disease compared to carriers of other forms like APOE3. There are immune cells in the brain called microglia that help protect the brain from damage and harm. But when APOE4 is expressed, microglia seem to start to cause inflammation, and misfolded proteins to form in the brain, which can lead to serious problems. The findings have been reported in Cell Stem Cell.

In this work, the researchers developed a mouse model that could generate the human APOE4 protein in their brains. Next, the investigators eliminated microglia from these mouse brains. The formation of two misfolded proteins that are hallmarks of Alzheimer’s diseases: amyloid and tau, was halted.

Read more | >

Summary: Autism-linked SHANK3 gene mutations disrupt not only neurons but also oligodendrocytes, essential for producing myelin, which insulates nerve fibers. This damage reduces brain signal efficiency and impairs behavior.

Using gene therapy, researchers successfully repaired these cells in a mouse model, restoring their function and myelin production. They validated their findings with human-derived stem cells, confirming similar impairments and repair mechanisms.

This discovery highlights a significant role for oligodendrocytes in autism and opens the door for innovative treatments targeting myelin dysfunction. The study underscores both the biological complexity of autism and the promise of genetic therapies for intervention.

Read more | >