Lifeboat Foundation

During that uncomfortable period between puberty and adulthood, the brain undergoes carefully orchestrated changes in gene expression and epigenetic modification. Alcohol, unfortunately, interferes with this biological architecture. Consequently, mistakes are made, and gene expression and modification do not go as planned, leaving the person vulnerable to a lifetime of psychiatric challenges, such as anxiety and alcoholism.

A team of researchers from the University of Illinois Chicago recently found they could reverse these changes in rats via gene editing. If their findings carry through to human studies, gene editing may be a potential treatment for anxiety and alcohol-use disorder in adults who were exposed to binge drinking in their adolescence.

Summary: Researchers used optogenetics techniques to stimulate specific brain areas to increase neurogenesis and the production of neural stem cells to improve memory, cognition, and emotional processing in animal models.

Source: UNC Health Care.

We humans lose mental acuity, an unfortunate side effect of aging. And for individuals with neurodegenerative conditions such as Alzheimer’s and Parkinson’s, the loss of cognitive function often accompanied by mood disorders such as anxiety is a harrowing experience. One way to push back against cognitive decline and anxiety would be to spur the creation of new neurons.

Scientists are attempting to map the wiring of the nearly 100 billion neurons in the human brain. Are we close to uncovering the mysteries of the mind or are we only at the beginning of a new frontier?

PARTICIPANTS: Deanna Barch, Jeff Lichtman, Nim Tottenham, David Van Essen.
MODERATOR: John Hockenberry.
Original program date: JUNE 4, 2017

Continue reading “Cartographers of the Brain” »

An experiment in mice has shown that a protein in the nervous system can have a rejuvenating effect on older animals, a finding which may help with future research into how to treat the neurological disease.

True stories of indefatigable researchers, heroic engineers, and champions of, neuroscience who are finally turning the corner in the effort to understand, heal, and improve the human brain.

Al has a hard time walking up the stairs to his home’s second floor these days, so he lives on the first. In a lounge chair, surrounded by pictures of his family and the homes he built, he slowly, carefully crosses one knee at the ankle like he’s in a business meeting. His legs are thin and pale and papery. His face, too, has taken on a gauntness since the photo of his daughter’s wedding, mounted on the wall right in front of him, was taken back in 2009. Al lunges forward as if he might stand. But then, when he tries to say hello, all that comes out is a guttural moan. When Al, who is sixty-eight, was diagnosed with progressive supranuclear palsy (PSP) in 2012, he was not guaranteed even this. The disease, caused by degeneration of cells in areas of the brain associated with movement, balance, and thinking, often results in death in about seven years. It has no known cause and no cure.

Engineering is often inspired by nature—the hooks in velcro or dermal denticles in sharkskin swimsuits. Then there’s DARPA’s SyNAPSE, a collaboration of researchers at IBM, XX, and XX universities. Not content with current computer architecture, SyNAPSE takes its cues from the human brain.

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Back in 2018, researchers were able to study the moment brain death becomes irreversible in the human body for the first time, observing the phenomenon in several Do Not Resuscitate patients as they died in hospital.

For years, scientists have researched what happens to your brain when you die, but despite everything we’ve found out, progress has been stymied by an inability to easily monitor human death – since physicians are conventionally obliged to prevent death if they can, not monitor it as it takes hold.

What this means is most of our understanding of the processes involved in brain death come from animal experiments, strengthened with what we can glean from the accounts of resuscitated patients disclosing their near-death experiences.

𝐍𝐞𝐰 𝐀𝐭𝐥𝐚𝐬:

The Neuro-Network.

𝐅𝐢𝐫𝐬𝐭-𝐞𝐯𝐞𝐫 𝐫𝐞𝐜𝐨𝐫𝐝𝐢𝐧𝐠 𝐨𝐟 𝐝𝐲𝐢𝐧𝐠 𝐡𝐮𝐦𝐚𝐧 𝐛𝐫𝐚𝐢𝐧 𝐫𝐞𝐯𝐞𝐚𝐥𝐬 𝐝𝐫𝐞𝐚𝐦𝐢𝐧𝐠-𝐥𝐢𝐤𝐞 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲

Continue reading “First-ever recording of dying human brain reveals dreaming-like activity” »