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Category: neuroscience – Page 302

Vaccinations against tetanus and diphtheria, pneumococcus, and herpes zoster (HZ)- better known as shingles, are linked to a reduced risk of Alzheimer’s disease (AD). The corresponding study was published in the Journal of Alzheimer’s Disease.

Viral, bacterial, and fungal infections increase the risk of neuroinflammation, which may cause or exacerbate neurodegeneration and dementia. Vaccines may thus reduce neurodegeneration and dementia risk by reducing the risk of infection. Previous research, for example, shows that people who receive at least one influenza vaccine are 40% less likely than unvaccinated peers to develop AD.

Currently, the Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) recommends older adults receive vaccines against tetanus, diphtheria and herpes zoster, and pneumococcus. The researchers behind the current study thus sought to see how these common vaccines may affect AD risk.

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Most of us who’ve reached middle age have noticed a slowing in memory and cognition, but scientists don’t have a clear picture of the molecular changes that take place in the brain to cause it.

Now, a study in mice has determined that the most pronounced changes occur in the white matter, a type of nervous system tissue that’s integral to transmitting signals across the brain. The study also examined two treatments — caloric restriction and infusions of plasma from young mice — that affect certain regions of the brain, with the plasma appearing to slow the age-related decline.

The results offer insight into the cognitive decline of normal aging, as well as the way aging contributes to neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases and multiple sclerosis.

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How looks life with na implant in brain.

Brain-computer interface technology is a fast-growing field but how does it feel to live with an implant inside of you?

In 2014, Ian Burkhart looked down at his hand and imagined closing it. To his astonishment, his hand did just that.

This was the first time a paraplegic person had regained the ability to move his arm by the sheer force of his thought, assisted by an implant in his brain.

Continue reading “How does it feel to live with a cerebral implant?” | >

The viral ALS Ice Bucket Challenge a few years ago raised major funding that resulted in the discovery of new genes connected to the disease. One of those genes is NEK1, in which mutations have been linked to as much as 2% of all ALS cases, making it one of the top-known causes of the disease.

But it wasn’t known how the mutated gene disrupts the function of the motor neuron and causes it to degenerate and die.

Northwestern Medicine scientists have discovered for the first time how this mutated gene leads to ALS (amyotrophic lateral sclerosis).

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We know that humans are an intelligent species. But this biologist breaks down the intelligence of each of our cells — and it will blow your mind.

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Michael Levin, a developmental biologist at Tufts University, challenges conventional notions of intelligence, arguing that it is inherently collective rather than individual.

Levin explains that we are collections of cells, with each cell possessing competencies developed from their evolution from unicellular organisms. This forms a multi-scale competency architecture, where each level, from cells to tissues to organs, is solving problems within their unique spaces.

Continue reading “Can cells think? | Michael Levin” | >

A research team headed by investigators at Brigham and Women’s Hospital reported on the results of a study in which they used stem cells from Alzheimer’s disease (AD) patients to identify a potential mechanism by which a gene known as SORL1 may impact the risk for the neurodegenerative disorder. Their work found that loss of normal SORL1 function leads to a reduction in two key proteins, APOE and CLU, which are known to be involved in AD, and which play an essential role in the neurons of healthy individuals. The study findings suggest a potential new strategy for AD treatment, especially for patients not responsive to existing therapies.

“Understanding the subtypes of AD is relatively new in the field of neurology research,” said Tracy Young-Pearse, PhD, of the Ann Romney Center for Neurological Diseases. “This is getting at a precision neurology approach, with which we can better predict which patients may be responsive to Alzheimer’s treatment strategies that attack specific genes or target the problems they cause.” Young-Pearse is corresponding author of the team’s published paper in Cell Reports, which is titled, “ Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1,” in which they concluded, “Taken together, we demonstrate that AD-relevant SORL1 loss of function results in neuron-specific reduction in APOE and CLU and dysregulated lipid homeostasis.”

AD varies widely in its age of onset, presentation, and severity. Key neurological features of AD, including the accumulation of amyloid-beta (Aβ) plaques in the brain, also vary across individuals. The anti-amyloid therapies, aducanumab and lecanemab, have received FDA accelerated and traditional approval, respectively, but not all patients respond to these drugs, warranting other treatment options.

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Neuroscientists at Radboud University show that adversities permanently change the functioning of the brain. Furthermore, an aberrant reaction of the brain to adversities is related to anxiety symptoms. This may have predictive value for the development of psychiatric disorders.

Your brain is shaped by the things you experience. That sounds logical, but can you really measure that? And what can you do with it? Neuroscientists at Radboud University investigated the influence of adversities in life on patterns in the brain. They found remarkable associations that may have predictive value for the development of psychiatric disorders.

The researchers conducted their study on approximately 170 people—a special group, because all kinds of data have been collected from them during their lifetime. For this study, the scientists specifically focused on adversities: factors or events that are known to have a negative effect on development. Consider, for example, the mother’s smoking during pregnancy, complications during childbirth, abuse, or a major accident.

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An injection of a specific blood factor can replicate exercise’s brain benefits, offering potential treatments for age-related cognitive decline.

Pre-clinical trials by University of Queensland scientists have found that an injection of a specific blood factor can replicate the benefits of exercise in the brain.

Dr. Odette Leiter and Dr. Tara Walker from UQ’s Queensland Brain Institute led a team that discovered platelets, the tiny blood cells critical for blood clotting, secrete a protein that rejuvenates neurons in aged mice in a similar way to physical exercise.

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A study published in Scientific Reports has shed light on the intricate relationship between the sense of presence in virtual reality (VR) environments and cognitive abilities. The study, titled “The role of sense of presence in expressing cognitive abilities in a virtual reality task: an initial validation study,” was conducted by a team of researchers coordinated by Dr. Andrea Chirico and marks a significant advancement in our understanding of how immersive technologies can influence cognitive functions.

The research team, which includes Prof. Antonio Giordano, Prof. Fabio Lucidi (Sapienza University of Rome), Dr. Luigi De Pietro (CNR ICAR, Italy), and others, set out to investigate the extent to which the sense of presence—the feeling of being “inside” a —impacts an individual’s cognitive performance. By employing advanced VR technology and designing a range of tasks to test cognitive abilities, the researchers were able to gather valuable insights.

One of the key findings of the study is that a stronger sense of presence is positively correlated with enhanced cognitive abilities. Participants who reported a heightened feeling of presence in the virtual tasks demonstrated improved performance in various cognitive domains. These domains include memory, attention, problem-solving, and decision-making.

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