Lifeboat Foundation

Computer simulations of complex systems provide an opportunity to study their time evolution under user control. Simulations of neural circuits are an established tool in computational neuroscience. Through systematic simplification on spatial and temporal scales they provide important insights in the time evolution of networks which in turn leads to an improved understanding of brain functions like learning, memory or behavior. Simulations of large networks are exploiting the concept of weak scaling where the massively parallel biological network structure is naturally mapped on computers with very large numbers of compute nodes. However, this approach is suffering from fundamental limitations. The power consumption is approaching prohibitive levels and, more seriously, the bridging of time-scales from millisecond to years, present in the neurobiology of plasticity, learning and development is inaccessible to classical computers. In the keynote I will argue that these limitations can be overcome by extreme approaches to weak and strong scaling based on brain-inspired computing architectures.

Bio: Karlheinz Meier received his PhD in physics in 1984 from Hamburg University in Germany. He has more than 25years of experience in experimental particle physics with contributions to 4 major experiments at particle colliders at DESY in Hamburg and CERN in Geneva. For the ATLAS experiment at the Large Hadron Collider (LHC) he led a 15 year effort to design, build and operate an electronics data processing system providing on-the-fly data reduction by 3 orders of magnitude enabling among other achievements the discovery of the Higgs Boson. Following scientific staff positions at DESY and CERN he was appointed full professor of physics at Heidelberg university in 1992. In Heidelberg he co-founded the Kirchhoff-Institute for Physics and a laboratory for the development of microelectronic circuits for science experiments. In particle physics he took a leading international role in shaping the future of the field as president of the European Committee for Future Accelerators (ECFA). Around 2005 he gradually shifted his scientific interests towards large-scale electronic implementations of brain-inspired computer architectures. His group pioneered several innovations in the field like the conception of a description language for neural circuits (PyNN), time-compressed mixed-signal neuromorphic computing systems and wafer-scale integration for their implementation. He led 2 major European initiatives, FACETS and BrainScaleS, that both demonstrated the rewarding interdisciplinary collaboration of neuroscience and information science. In 2009 he was one of the initiators of the European Human Brain Project (HBP) that was approved in 2013. In the HBP he leads the subproject on neuromorphic computing with the goal of establishing brain-inspired computing paradigms as tools for neuroscience and generic methods for inference from large data volumes.

When young, these neurons signal fatty tissues to release energy fueling the brain. With age, the line breaks down. Fat cells can no longer orchestrate their many roles, and neurons struggle to pass information along their networks.

Using genetic and chemical methods, the team found a marker for these neurons—a protein called Ppp1r17 (catchy, I know). Changing the protein’s behavior in aged mice with genetic engineering extended their life span by roughly seven percent. For an average 76-year life span in humans, the increase translates to over five years.

The treatment also altered the mice’s health. Mice love to run, but their vigor plummets with age. Reactivating the neurons in elderly mice revived their motivation, transforming them from couch potatoes into impressive joggers.

In the fifth decade of life, our brains start to undergo a radical “rewiring” that results in diverse networks becoming more integrated over the ensuing decades. ⁠ https://bigthink.com/neuropsych/great-brain-rewiring-after-age-40/ Big Think.

In a systematic review published last year in the journal Psychophysiology, researchers from Monash University in Australia swept through the scientific literature, seeking to summarize how the connectivity of the human brain changes over our lifetimes. The gathered evidence suggests that in the fifth decade of life (that is, after a person turns 40), the brain starts to undergo a radical “rewiring” that results in diverse networks becoming more integrated and connected over the ensuing decades, with accompanying effects on cognition.

Since the turn of the century, neuroscientists have increasingly viewed the brain as a complex network, consisting of units broken down into regions, sub-regions, and individual neurons. These units are connected structurally, functionally, or both. With increasingly advanced scanning techniques, neuroscientists can observe the parts of subjects’ brains that “light up” in response to stimuli or when simply at rest, providing a superficial look at how our brains are synced up.

Continue reading “The brain undergoes a great ‘rewiring’ after age 40” »

Research indicates enhanced mental function in individuals who maintain an active lifestyle and engage in social interactions, alongside managing blood pressure and diabetes effectively.

As federal approval for more Alzheimer’s disease medications progresses, a recent study conducted by UC San Francisco and Kaiser Permanente Washington reveals that tailored health and lifestyle modifications can postpone or prevent memory deterioration in older adults at increased risk.

The two-year study compared cognitive scores, risk factors, and quality of life among 172 participants, of whom half had received personalized coaching to improve their health and lifestyle in areas believed to raise the risk of Alzheimer’s, such as uncontrolled diabetes and physical inactivity. These participants were found to experience a modest boost in cognitive testing, amounting to a 74% improvement over the non-intervention group.

Cognitive neuroscientist Clayton Curtis describes an elegant experiment that leads us to ask: Does the brain honor the distinction implied in most textbooks between spatial attention, motor control, and spatial working memory?

For more info/content, please visit: https://postlab.psych.wisc.edu/cog-ne…

Continue reading “Attention, intention, and retention in frontoparietal cortex” »

Have you ever wondered why SSRIs take time to show effects? A new study has delved into why antidepressants like SSRIs take weeks to start working and how this may impact mental health care.

SSRIs, or Selective Serotonin Reuptake Inhibitors, belong to a category of antidepressant drugs designed to elevate serotonin levels in the brain. Notable examples of SSRIs include fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro).

Continue reading “Why do antidepressants take so long to kick in?” »

A recent neuroimaging study shows psilocybin, found in magic mushrooms, significantly alters brain connectivity in alcohol-dependent rats. This mirrors effects seen in humans, offering new avenues for researching the therapeutic impact of psychedelics.

Not science per se, but factual and I’ll admit I feel drained a lot.

In today’s column, I will examine closely the recent launch of the OpenAI ChatGPT online GPT store that allows users to post GPTs or chatbots for ready use by others, including and somewhat alarmingly a spate of such chatbots intended for mental health advisory purposes.

OpenAI has launched their awaited GPT Store. This is great news. But there are also mental health GPTs that are less than stellar. I take a close look at the issue.