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Category: neuroscience – Page 146

Reversing Age by 54% with E5

An important update on E5.

Here we look at an attempt to replicate the amazing results with E5 from Dr Katcher’s 2020 paper by an institute that has been set up in Brazil.
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Childhood Trauma Leaves Lasting Imprint on Muscle Function

Next in our New Year countdown, a study found that traumatic experiences during childhood may impair muscle function later in life.

Read more.

A University of Michigan study has shown that traumatic experiences during childhood may get “under the skin” later in life, impairing the muscle function of people as they age.

The study examined the function of skeletal muscle of older adults paired with surveys of adverse events they had experienced in childhood. It found that people who experienced greater childhood adversity, reporting one or more adverse events, had poorer muscle metabolism later in life. The research, led by University of Michigan Institute for Social Research scientist Kate Duchowny, is published in Science Advances.

Duchowny and her co-authors used muscle tissue samples from people participating in the Study of Muscle, Mobility and Aging, or SOMMA. The study includes 879 participants over age 70 who donated muscle and fat samples as well as other biospecimens. The participants also were given a variety of questionnaires and physical and cognitive assessments, among other tests.

Doctors Reveal Surge Behind ‘Silent Killer’ in Gen Z and Millenials and One Way to Reduce the Risk

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Young people don’t worry about their health the same way older individuals do. Of course, many Gen Zers and Millenials do prioritize their physical and mental wellbeing. But they are young, while the risk of life-changing conditions like heart disease, diabetes, chronic pain, and cancer increases with age. However, research shows that Gen Z and Millenials are not as safe as once thought. The number of cases of colon cancer has doubled in the United States since the 1990s. Especially in the age 20 to 49 demographic.

Colon cancer is also known as colorectal cancer, bowel cancer, or rectal cancer — depending on where the tumor begins. It’s also called the silent killer because there may be few or zero warning signs. And once the symptoms finally appear, the cancer has already progressed.

According to the Colon Cancer Coalition (CCC), colorectal cancer is the fourth most commonly diagnosed cancer, and the second leading cause of death due to cancer. Moreover, 30% of its diagnoses are for individuals under the age of 55. This has made it the leading cause of cancer death for men and the second leading for women under the age of 50.

Reveal Spatial Biomarkers With Multiplexed Imaging Mass Cytometry

Understanding the cellular composition of tissues is key for interpreting neural disease origin, progression and more. This whitepaper explores a method to aid this.

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To interpret neural disease origin, progression, prognosis and treatment options, it is essential to understand the cellular and spatial composition of neural tissues.

Imaging mass cytometry (IMC) overcomes the limitations of traditional cyclic fluorescent methods to uncover the spatial distribution of over 40 distinct protein markers simultaneously, without interference from the tissue degradation and autofluorescence artifacts usually found in brain tissue.

This whitepaper explores the translational and clinical applications of IMC to develop biomarkers and future treatment strategies in neuro-oncology and neurodegenerative studies.

TEMPORAL MECHANICS: D-Theory of Time | Deep Dive AI Podcast

Synchronicity!😉 Just a few hours ago I watched a video which stated that the philosopher Henri Bergson argued our linear perception of time limited our ability to appreciate the relationship between time and consciousness.

What if our understanding of time as a linear sequence of events is merely an illusion created by the brain’s processing of reality? Could time itself be an emergent phenomenon, arising from the complex interplay of quantum mechanics, relativity, and consciousness? How might the brain’s multidimensional computations, reflecting patterns found in the universe, reveal a deeper connection between mind and cosmos? Could Quantum AI and Reversible Quantum Computing provide the tools to simulate, manipulate, and even reshape the flow of time, offering practical applications of D-Theory that bridge the gap between theoretical physics and transformative technologies? These profound questions lie at the heart of Temporal Mechanics: D-Theory as a Critical Upgrade to Our Understanding of the Nature of Time, 2025 paper and book by Alex M. Vikoulov. D-Theory, also referred to as Quantum Temporal Mechanics, Digital Presentism, and D-Series, challenges conventional views of time as a fixed, universal backdrop to reality and instead redefines it as a dynamic interplay between the mind and the cosmos.

Time, as experienced by humans, is more than a sequence of events dictated by physical laws. It emerges from our awareness of change, a psychological construct shaped by consciousness. Recent advancements in neuroscience, quantum physics, and cognitive science reveal fascinating parallels between the brain and the universe. Studies suggest that neural processes operate in up to 11 dimensions, echoing M-Theory’s depiction of a multiverse with similar dimensionality. These insights hint at a profound structural resemblance, where the brain and the cosmos mirror each other as interconnected systems of information processing.

Quantum Temporal Mechanics goes further, positing that consciousness not only perceives time but actively participates in its manifestation. In quantum theory, the observer plays a pivotal role in collapsing wavefunctions, a process that may extend beyond the microcosm to the fabric of reality itself. Various interpretations of quantum mechanics, such as Quantum Bayesianism and Consciousness Causes Collapse theory, support the idea that the observer’s awareness helps shape how time unfolds. In this framework, the flow of time becomes a participatory phenomenon, where consciousness and the universe co-create the temporal experience.

The implications of this perspective are far-reaching. By placing consciousness at the center of temporal reality, D-Theory suggests that the universe operates as a self-simulating quantum neural network—a vast, intelligent system continuously evolving and self-regulating. Reality itself becomes an active, dynamic process in which every quantum event contributes to the universe’s collective intelligence, much like neurons firing in a biological brain. This conceptualization reimagines the universe as a living, thinking entity, where time, space, and experience are constructs shaped by a universal consciousness.

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The Hidden Culprit Behind Alzheimer’s Revealed: Microglia Under the Microscope

Researchers at the CUNY Graduate Center have made a groundbreaking discovery in Alzheimer’s disease research, identifying a critical link between cellular stress in the brain and disease progression.

Their study focuses on microglia, the brain’s immune cells, which play dual roles in either protecting or harming brain health. By targeting harmful microglia through specific pathways, this research opens new avenues for potentially reversing Alzheimer’s symptoms and providing hope for effective treatments.

Key cellular mechanism driving alzheimer’s disease identified.

Scientists uncover insights into neuron function by simultaneously measuring two key signals in living animals

Researchers from Kyushu University have developed an innovative technique to non-invasively measure two key signals, membrane voltage and intracellular calcium levels, at the same time, in neurons of awake animals. This new method offers a more complete understanding of how neurons function, revealing that these two signals encode different information for sensory stimuli. The research was published in Communications Biology on September 16, 2024.

Neurons are cells that act as the brain’s fundamental building blocks, transmitting information through . When a neuron receives a stimulus, changes in membrane voltage (the electrical charge across the neuron cell membrane) trigger the neuron to activate, causing rapid changes in membrane voltage to propagate along the neuron as an electrical signal. These changes in membrane voltage then lead to changes in intracellular calcium (calcium levels inside neurons).

Historically, measuring membrane voltage has involved invasive techniques using electrodes. As a non-invasive alternative, scientists have developed techniques to measure calcium activity using fluorescent proteins that are sensitive to calcium ions as sensors, providing an indirect proxy for neuron activity. However, these different methods mean that the two signals have almost always been studied separately, making it challenging to understand how they interact in real-time and to identify their distinct functions in living animals.

These surprising professions have the lowest rate of Alzheimer’s disease deaths

The two professions associated with the lowest levels of death due to Alzheimer’s disease may be surprising.

Taxi and ambulance drivers were found to have the lowest proportion of deaths of more than 440 occupations that were considered in a new observation-based study from Massachusetts physicians.

Alzheimer’s disease is a type of dementia that affects memory, thinking, and behavior. It impacts millions of Americans and is one of the top 10 causes of death in the US.

Brain tumor organoids accurately model patient response to CAR T cell therapy

For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient’s response to CAR T cell therapy in real time. The organoid’s response to therapy mirrored the response of the actual tumor in the patient’s brain. That is, if the tumor-derived organoid shrunk after treatment, so did the patient’s actual tumor, according to new research from the Perelman School of Medicine, published in Cell Stem Cell.

Lab-grown tumors respond to cell therapy the same as tumors in the patients’ brains, according to researchers at Penn Medicine.