Lifeboat Foundation

This video is part of the open course “Neuroscience for machine learners”. Find out more at https://neuro4ml.github.io/

Summary: Researchers unveiled a groundbreaking discovery that DNA damage and brain inflammation are vital processes for forming long-term memories, particularly within the brain’s hippocampus.

Contrary to previous beliefs associating inflammation with neurological diseases, this study highlights inflammation’s critical role in memory formation through the activation of the Toll-Like Receptor 9 (TLR9) pathway following DNA damage in hippocampal neurons.

These findings not only challenge conventional views on brain inflammation but also caution against indiscriminate inhibition of the TLR9 pathway, given its importance in memory encoding and the potential risks of genomic instability.

March 27, 2024—(BRONX, NY)— Just as you can’t make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can’t make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.

“Inflammation of brain neurons is usually considered to be a bad thing, since it can lead to neurological problems such as Alzheimer’s and Parkinson’s disease,” said study leader Jelena Radulovic, M.D., Ph.D., professor in the Dominick P. Purpura Department of Neuroscience, professor of psychiatry and behavioral sciences, and the Sylvia and Robert S. Olnick Chair in Neuroscience at Einstein. “But our findings suggest that inflammation in certain neurons in the brain’s hippocampal region is essential for making long-lasting memories.”

The hippocampus has long been known as the brain’s memory center. Dr. Radulovic and her colleagues found that a stimulus sets off a cycle of DNA damage and repair within certain hippocampal neurons that leads to stable memory assemblies—clusters of brain cells that represent our past experiences. Elizabeth Wood, a Ph.D. student, and Ana Cicvaric, a postdoc in the Radulovic lab, were the study’s first authors at Einstein.

Medical office procedure identifies key biomarker that may lead to more reliable diagnosis of neurodegenerative disorders.

Gert-Jan Oskam was living in China in 2011 when he was in a motorcycle accident that left him paralyzed from the hips down.

In a new study, researchers describe a device that connects the intentions of a paralyzed patient to his physical movements.

In an alarming exposé, several women have come forward accusing neuroscientist and celebrated podcaster Andrew Huberman of manipulation, bizarre behavior, and infidelity that may have led to a sexually transmitted infection in at least one of them.

Published by New York Magazine, this deep dive into the disparate public and private lives of the Stanford University neuroscientist illustrates a jarring portrait of a man who promotes physical and mental health and wellness — but engaged in bizarre interpersonal behavior, including secretly dating five women simultaneously.

Much of the story centers around a woman whom NYMag calls Sarah, who spent years dating the “Huberman Lab” host in what she believed to be an exclusive relationship. Along with accusing the 48-year-old podcaster of obfuscating about his other relationships, Sarah described Huberman as being intense and controlling, including — in a particularly unhinged twist — constantly relitigating her romantic and reproductive decisions from back before they were together.

He helped pioneer a branch of the field that exposed hard-wired mental biases in people’s economic behavior. The work led to a Nobel.

Northwestern Medicine investigators have identified a metabolism-related gene that may play a role in recruiting immune cells to support the growth of aggressive brain tumors, according to a study recently published in Nature Communications.

Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure, according to a study published March 13 in Nature.

The research reveals how dietary tryptophan—an amino acid found mostly in animal products, nuts, seeds, whole grains and legumes—can be broken down by gut bacteria into small molecules called metabolites. It turns out a few of these metabolites can bind to a receptor on gut epithelial (surface) cells, triggering a pathway that ultimately reduces the production of proteins that E. coli use to attach to the gut lining where they cause infection. When E. coli fail to attach and colonize the gut, the pathogen benignly moves through and passes out of the body.

The research describes a previously unknown role in the gut for a receptor, DRD2 has otherwise been known as a dopamine (neurotransmitter) receptor in the central and peripheral nervous systems.