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Category: neuroscience – Page 109

Cambridge study shows stem cell grafts can restore myelin in MS lesions in mice

Multiple sclerosis (MS) is an autoimmune disease where the body’s immune system mistakenly attacks the central nervous system, leading to the destruction of myelin, the protective sheath surrounding nerve fibres. This damage is a leading cause of neurological disability in young adults.

In the early stages of MS, certain cells possess the capacity to partially repair this damage by generating new myelin. However, this regenerative ability reduces significantly in the later, chronic progressive stage of the disease. This decline in repair contributes to further damage to neurons and increasing disability in individuals with progressive MS.

Despite advancements in treatments, current therapies mostly focus on managing symptoms but do not halt or reverse the damage and neurodegeneration caused. This shows the critical need for a more profound understanding of how MS progresses and to explore how stem cell technologies could help MS treatment.

The study, published in the journal Brain, was spearheaded by University of Cambridge scientist Dr. Luca Peruzzotti-Jametti and offers crucial insights into the potential of neural stem cell transplantation in people with progressive MS. While neural stem cell transplants present a promising avenue for repairing the damaged central nervous system, the limits of their capacity to repair are being investigated by researchers.

(Utilizng stem cells for many innovative treatments is not a question of how, but rather when)

A study led by Cambridge researchers has shed light on how neural stem cell grafts could help restore myelin in the central nervous system. The findings suggest that neural stem cell-based therapies hold promise as a potential treatment for chronic demyelinating disorders, particularly progressive multiple sclerosis.

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Mental time travel: A new case of autobiographical hypermnesia

Remembering past events in minute detail, revisiting them methodically, and reliving past emotions—this is the peculiarity of people with an exceptional memory of their own lives, known as autobiographical hypermnesia, or hyperthymesia. This fascinating condition remains poorly understood, and each new case contributes to our understanding.

In an article in Neurocase, researchers from Paris Brain Institute and the Memory, Brain, and Cognition Laboratory describe the extraordinary mental life of a 17-year-old girl.

Autobiographical memory refers to our ability to remember experiences that have shaped our lives since childhood. It consists of emotional and sensory memories of places, moments, and people, as well as a set of factual information—such as names and dates—that allows us to orient ourselves when we try to recall an episode from the past.

Microglia gene activity shifts across Alzheimer’s stages, revealing possible therapy targets

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that causes progressive memory loss and a decline in mental (i.e., cognitive) abilities. Statistics suggest that between 500,000 and 900,000 people are diagnosed with this disease every year, while several hundreds of thousands experience dementia or other aging-related cognitive decline.

While there are some available treatments designed to delay cognitive decline in individuals with mild or moderate AD symptoms, a cure for the disease has not yet been identified. A better understanding of the neural, genetic, cellular and that contribute to the disease’s progression, as well as to neurodegeneration in general, could thus be highly valuable, as it could inform the future development of alternative treatments.

Past neuroscience research has identified the key role of microglia in AD. These are specialized that monitor the environment in the brain, clearing out , debris and pathogens. The dysregulation of these cells has been linked to neurodegeneration and to the progression of AD.

Breathwork can induce altered states of consciousness linked with changes in brain blood flow

Breathwork while listening to music may induce a blissful state in practitioners, accompanied by changes in blood flow to emotion-processing brain regions, according to a study published in the open-access journal PLOS One by Amy Amla Kartar from the Colasanti Lab in the Department of Clinical Neuroscience at Brighton and Sussex Medical School, U.K., and colleagues.

These changes occur even while the body’s stress response may be activated and are associated with reporting reduced negative emotions.

The popularity of breathwork as a therapeutic tool for psychological distress is rapidly expanding. Breathwork practices that increase ventilatory rate or depth, accompanied by music, can lead to altered states of consciousness (ASCs) similar to those evoked by psychedelic substances.

‘Unhappiness hump’ in aging may have disappeared worldwide

A new survey-based study suggests that the “unhappiness hump”—a widely documented rise in worry, stress, and depression with age that peaks in midlife and then declines—may have disappeared, perhaps due to declining mental health among younger people. David Blanchflower of Dartmouth College, U.S., and colleagues present these findings in the open-access journal PLOS One.

Since 2008, a U-shaped trend in well-being with age, in which well-being tends to decline from childhood until around age 50 before rebounding in old age, has been observed in developed and developing countries worldwide. Data have also revealed a corresponding “ill-being” or hump.

Recent data point to a worldwide decline in well-being among younger people, but most studies have not directly addressed potential implications for the unhappiness hump. To help clarify, Blanchflower and colleagues first analyzed data from U.S. and U.K. surveys that included questions about participants’ .

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