A new study offers insight into what is happening in our brains when our working memory must use its limited resources to remember multiple things.
Researchers found that two parts of the brain work together to ensure that more brain resources are given to remember a priority item when a person is juggling more than one item in memory.
The study involved people remembering spatial locations. Imagine seeing two books on different shelves of a cluttered bookcase that was not arranged in any order. How could you remember where they were if you came back a few seconds later?
Researchers at Baylor College of Medicine, Texas Children’s Hospital, the Hospital for Sick Children in Toronto and collaborating institutions reveal in Nature Cell Biology a strategy that helps medulloblastoma, the most prevalent malignant brain tumor in children, spread and grow on the leptomeninges, the membranes surrounding the brain and spinal cord.
They discovered a novel line of communication between metastatic medulloblastoma and leptomeningeal fibroblasts that mediates recruitment and reprogramming of the latter to support tumor growth. The findings suggest that disrupting this communication offers a potential opportunity to treat this devastating disease.
“Metastases, the spreading of a tumor away from its original site, are the most common and most important cause of illness and death for children with medulloblastoma,” said co-first author Dr. Namal Abeysundara, a postdoctoral fellow who was working in the lab of Dr. Michael D. Taylor at the Arthur and Sonia Labatt Brain Tumor Research Center and the Developmental and Stem Cell Biology Program at the Hospital for Sick Children in Toronto, Canada during this project.
People with Alzheimer’s disease may retain their ability to empathize, despite declines in other social abilities, finds a new study led by University College London (UCL) researchers.
The researchers found that people with Alzheimer’s disease scored slightly higher on a measure of empathy than peers of the same age with mild cognitive impairment, despite scoring worse on other measures of social cognition such as recognizing facial emotions and understanding the thoughts of others.
The authors of the study, published in Alzheimer’s & Dementia, say this may be the first time a cognitive domain has been found to improve in dementia.
A brief episode of anxiety may have a bigger influence on a person’s ability to learn what is safe and what is not. Research recently published in npj Science of Learning has used a virtual reality game that involved picking flowers with bees in some of the blossoms that would sting the participant—simulated by a mild electrical stimulation on the hand.
Researchers worked with 70 neurotypical participants between the ages of 20 and 30. Claire Marino, a research assistant in the ZVR Lab, and Pavel Rjabtsenkov, a Neuroscience graduate student at the University of Rochester School of Medicine and Dentistry, were co-first authors of the study.
Their team found that the people who learned to distinguish between the safe and dangerous areas—where the bees were and were not—showed better spatial memory and had lower anxiety, while participants who did not learn the different areas had higher anxiety and heightened fear even in safe areas.
Researchers led by Jean-Paul Noel at the University of Minnesota, United States, have decoupled intentions, actions and their effects by manipulating the brain-machine interface that allows a person with otherwise paralyzed arms and legs to squeeze a ball when they want to.
Published in the open-access journal PLOS Biology, the study reveals temporal binding between intentions and actions, which makes actions seem to happen faster when they are intentional.
Separating intentions from actions was made possible because of a brain-machine interface. The participant was paralyzed with damage to their C4/C5 vertebrae and had 96 electrodes implanted in the hand region of their motor cortex.
Will a child who’s evaluated for autism later develop an intellectual disability? Can this be accurately predicted? Early-childhood experts in Quebec say they’ve have come up with a better way to find out.
In a study of 5,633 children drawn from three North American cohorts, clinician-researchers affiliated with Université de Montréal developed a new predictive model that combines a wide range of genetic variants with data on each stage of a young child’s development.
Their goal? To obtain reliable information as early as possible to predict the children’s developmental trajectory and thus offer more proactive support to those who may need it—namely, parents trying to better understand and anticipate their child’s needs.