New research supported by the Wu Tsai Neurosciences Institute’s Interdisciplinary Postdoctoral Scholars program zeroes in on the surprising observation that many genes found in brain cells and synapses—the points of communication between neurons—are among the largest in the animal kingdom.
The ability to link mind and machine has long been the realm of science fiction, but now improvements in our understanding may allow us to network brain to computer in the near future. Companies like Neurolink have begun to explore how to link our neurons to machine, and we’ll explore now such neural interfaces might function and how they might change our lives.
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“In adults with diabetes alone—where poor blood flow can lead to quickly worsening wounds that are often very slow or impossible to heal—the lifetime risk of developing a diabetic foot ulcer (DFU), the most common diabetes-related wound, is 20–35 percent and this number is rising with increased longevity and medical complexity of people with diabetes,” stated lead author, Yen-Zhen Lu, PhD, an investigator at ARMI.
Nociceptors— neurons that sense pain, tissue damage, and inflammation, among other functions— respond to wounds by producing a neuropeptide called calcitonin gene-related peptide (CGRP). “Nociceptor endings grow into injured skin and muscle tissues and signal to immune cells through the neuropeptide CGRP during the healing process,” the authors wrote. Immune cell response in neutrophils, monocytes, and macrophages are modified to encourage active repair in the region.
Individuals with diseases like diabetes or elderly people have reduced production of CGRP, leading to poor, inefficient, or incomplete wound healing. The new study explores the impact of CGRP alone by introducing it into diabetic mice as well as mice without nociceptors. “Delivery of an engineered version of CGRP accelerated wound healing and promoted muscle regeneration,” the authors wrote. “Remarkably, this neuropeptide acts on immune cells to control them, facilitating tissue healing after injury,” added co-author Mikaël Martino, PhD, associate professor, ARMI.
Imagine playing a racing game like Mario Kart, using only your brain to execute the complex series of turns in a lap.
A new study indicates a link between sleep apnea and increased memory or thinking problems, based on self-reported data from over 4,000 participants.
People who experience sleep apnea may be more likely to also have memory or thinking problems, according to a preliminary study that will be presented at the American Academy of Neurology’s 76th Annual Meeting taking place April 13–18, 2024, in person in Denver and online. The study shows a positive association but did not determine whether sleep apnea causes cognitive decline.
Sleep apnea is when people stop and restart breathing repeatedly during sleep which can lower oxygen levels in the blood. Symptoms include snorting, gasping, and breathing pauses. People with the disorder may also experience morning headaches or have trouble focusing on tasks.
Direct mesh supervision for neural radiance field representation and generation.
We present Mesh2NeRF, an approach to derive ground-truth radiance fields from textured meshes for 3D generation tasks.
Join the discussion on this paper page.
Christian Lemon, Ph.D., an associate professor in the School of Biological Sciences at the University of Oklahoma, often thinks about temperature sensation and the brain when eating a chilled mint cookie. Now, research from his lab examining oral temperature perception has been published in The Journal of Neuroscience.
In their research, Lemon’s team investigates how cold receptors in the mouth are activated by cooling temperatures, how those signals are transmitted to the brain and how those transmissions are generated into a cooling sensation.
A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke.
The new research, published in Neurology, the medical journal of the American Academy of Neurology, is the most comprehensive systematic review of ‘hidden’ brain changes in people with a range of heart conditions to date.
Lead author Dr Zien Zhou from The George Institute for Global Health said that identifying these changes could play an important role in choosing treatments for these patients.
Levels of spinal fluid amyloid become abnormal long before Alzheimer disease is clinically apparent, a recent study shows.
