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Category: nanotechnology – Page 287

Nice.

Nanorobots and other mini-vehicles might be able to perform important services in medicine one day – for example, by conducting remotely-controlled operations or transporting pharmaceutical agents to a desired location in the body. However, to date it has been hard to steer such micro- and nanoswimmers accurately through biological fluids such as blood, synovial fluid or the inside of the eyeball.

Researchers at the Max Planck Institute for Intelligent Systems in Stuttgart are now presenting two new approaches for constructing propulsion systems for tiny floating bodies. In the case of one motor, the propulsion is generated by bubbles which are caused to oscillate by ultrasound (Applied Physics Letters, “Wireless actuation with functional acoustic surfaces”). With the other, a current caused by the product of an enzymatic reaction propels a nanoswimmer (JACS, “Bubble-Free Propulsion of Ultrasmall Tubular Nanojets Biocatalytic Reactions”).

an enzyme-propelled nanorobot

An enzyme-propelled nanorobot: urease-coated nanotubes turn into a propulsion system in a urea-containing liquid because the enzyme breaks down the urea into gaseous products. Since the tubes always have small asymmetries, the reaction products generate a current in the fluid which propels them out of the tube like a jet. (Image: MPI for Intelligent Systems)

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‘Caged’ non-fluorescent carbon dot enters the cancer cell, loses its caging and lights up. Credit: University of Illinois.

Tiny carbon dots have, for the first time, been applied to intracellular imaging and tracking of drug delivery involving various optical and vibrational spectroscopic-based techniques such as fluorescence, Raman, and hyperspectral imaging. Researchers from the University of Illinois at Urbana-Champaign have demonstrated, for the first time, that photo luminescent carbon nanoparticles can exhibit reversible switching of their optical properties in cancer cells.

“One of the major advantages of these agents are their strong intrinsic optical sensitivity without the need for any additional dye/fluorophore and with no photo-bleaching issues associated with it,” explained Dipanjan Pan, an assistant professor of bioengineering and the leader of the study. “Using some elegant nanoscale surface chemistry, we created a molecular ‘masking’ pathway to turn off the fluorescence and then selectively remove the mask leading to regaining the brightness.

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In Brief:

Researchers found a new “supercomputer” using nanotechnology. These biocomputers can solve mathematical problems faster, and they are more energy efficient.

Researchers from Lund University in Sweden have created a biological computer using nanotechnology. This, in itself, is not so remarkable, but it can solve mathematical problems much faster than conventional computers. The team was also able to prove that biological computers using molecular motors are more energy efficient.

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Great read and highlights what I have been showing folks around the convergence that is occurring between technology and biology via Quantum. We’re achieving (in the Epoch chart on Singularity Evolution) Epoch 5 via Quantum Bio and our work we’re seeing from DARPA, Microsoft, Amazon, Google, and others. Synbio has to mimic the properties we see with Quantum Biology/ Biosystems. And, things like DARPA’s own RadioBio will enable and expose many things on multiple fronts in Biosensors (including security), IoT, healthcare/ medical prevention management and treatments, AI, etc.

Singularity – the state of being singular; Oneness.

The biological system is a natural form of technology. A simple examination of the nanobiology of the macromolecular system of any cell will attest to this – enzymes and structural proteins are veritable nanomachines, linked to the information processing network of DNA and plasma membranes. Far from being a primordial or rudimentary organic technology – we are discovering more and more the level of complexity and paragon technological sophistication of living systems, which as is being discovered, even includes non-trivial quantum mechanical phenomena once thought to only be possible in the highly specialized and controlled environment of the laboratory.

Reciprocally, soon our technologies will become living systems – particularly through nanotechnology (which is being accomplished through reverse engineering and hybridization with biomolecules, particularly DNA) and general artificial intelligence – machine sentience. Following this parallelization of biology with technology, we can examine how humanity as a technological supraorganism is undergoing a period of punctuated speciation – an evolutionary transformation of both our inner and outer world.

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I don’t know how to say this; however, Apple has already shared their own experiment Li-Fi over a year ago; now this from IEEE.

Now an advance by a team of researchers from the University of Illinois at Urbana–Champaign, the Electronics and Telecommunications Research Institute in South Korea and Dow Chemical may turn the display market on its head by eliminating the need for backlights in LCD devices. They have produced a LED pixel out of nanorods capable of both emitting and detecting light.

In the video below, you can get a further description of how the nanorods manage to both detect and emit light as well as some pretty attractive future applications, like mobile phones that can “see” without the need of a camera lens or communicate with each other using Light Fidelity (Li-Fi) technology.

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A biopharmaceutical company focused on the development and commercialization of innovative therapeutics for disease intersections of arthritis, hypertension, and cancer, today announced that they have entered into a license agreement regarding the Company’s SMARTICLES platform for the delivery of nanoparticles including small molecules, peptides, proteins and biologics…

Marina Biotech, Inc. a biopharmaceutical company focused on the development and commercialization of innovative therapeutics for disease intersections of arthritis, hypertension, and cancer, today announced that they have entered into a license agreement regarding the Company’s SMARTICLES platform for the delivery of nanoparticles including small molecules, peptides, proteins and biologics. This represents the first time that the Company’s SMARTICLES technologies have been licensed in connection with nanoparticles delivering small molecules, peptides, proteins and biologics. Under terms of the agreement, Marina could receive up to $90MM in success based milestones. Further details of the agreement were not disclosed.

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Interesting read for those interested in inorganic protein (NP) states from a solid to a liquid as the research proves inorganic NPs are in a ‘glassy’ state while transitioning from a solid to a liquid form.

Molecular dynamics simulations of ubiquitin in water/glycerol solutions are used to test the suggestion by Karplus and coworkers that proteins in their biologically active state should exhibit a dynamics similar to ‘surface-melted’ inorganic nanoparticles (NPs). Motivated by recent studies indicating that surface-melted inorganic NPs are in a ‘glassy’ state that is an intermediate dynamical state between a solid and liquid, we probe the validity and significance of this proposed analogy. In particular, atomistic simulations of ubiquitin in solution based on CHARMM36 force field and pre-melted Ni NPs (Voter-Chen Embedded Atom Method potential) indicate a common dynamic heterogeneity, along with other features of glass-forming (GF) liquids such as collective atomic motion in the form of string -like atomic displacements, potential energy fluctuations and particle displacements with long range correlations (‘colored’ or ‘pink’ noise), and particle displacement events having a power law scaling in magnitude, as found in earthquakes. On the other hand, we find the dynamics of ubiquitin to be even more like a polycrystalline material in which the α-helix and β-sheet regions of the protein are similar to crystal grains so that the string -like collective atomic motion is concentrated in regions between the α-helix and β-sheet domains.

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Nice.

Researchers at the University of Central Florida (UCF) in the US are combining nanoscience with the principle of Faraday rotation, a magnetic phenomenon discovered in 1845, in a new method for speedy medical tests.

The team applied the magneto-optical technique, called frequency-domain Faraday rotation spectroscopy—or fd-FRS, to characterize proteins, using antibody-functionalized magnetic nanoparticles (MNPs).

“Fd-FRS is a new way of looking at the interaction between light and magnetized material,” says Shawn Putnam, assistant professor UFC’s College of Engineering & Computer Science. “We covered the surfaces of magnetic nanoparticles with a layer of biological sensors and measured their movement after exposure to their corresponding biological targets for detection.”

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IBM researchers have established experimental proof of a previously difficult-to-prove law of physics, and in so doing may have pointed to a way to overcome many of the heat management issues faced in today’s electronics. Researchers at IBM Zurich have been able to take measurements of the thermal conductance of metallic quantum point contacts made of gold. No big deal, you say? They conducted measurements at the single-atom level, at room temperature—the first time that’s ever been done.

These measurements confirm the Wiedemann–Franz law, which predicts that the smallest amount of heat that can be carried across a metallic junction — a single quantum of heat — is directly proportional to the quantum of electrical conductance through the same junction. By experimentally confirming this law, it can now be used with confidence to predict and to explore nanoscale thermal and electrical phenomena affecting materials down to the size of few atoms or a single molecule.

“Although the Wiedemann–Franz law is predicted, and should be valid for certain metals, it has turned out to be difficult to prove it when you go to the nanoscale,” explained Bernd Gotsmann, an IBM scientist and one of the lead researchers on this work, in an e-mail interview with IEEE Spectrum. “We think the difficulty is mainly a sign of the challenges related to the measurement of thermal transport on small scales.”

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