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Category: nanotechnology – Page 289

Novel Drug Delivery Particles Use Neurotransmitters as a ‘Passport’ Into the Brain

Summary: Tufts researchers have developed neurotransmitter-lipid hybrids that help transport therapeutic drugs and gene editing proteins across the blood-brain barrier in mice.

Source: Tufts University

Biomedical engineers at the Tufts University School of Engineering have developed tiny lipid-based nanoparticles that incorporate neurotranmitters to help carry drugs, large molecules, and even gene editing proteins across the blood-brain barrier and into the brain in mice. The innovation, published today in Science Advances, could overcome many of the current limitations encountered in delivering therapeutics into the central nervous system, and opens up the possibility of using a wide range of therapeutics that would otherwise not have access to the brain.

Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection

Utilizing neurotransmitters as a passport into the brain:

Safe and efficient delivery of blood-brain barrier (BBB)–impermeable cargos into the brain through intravenous injection remains a challenge. Here, we developed a previously unknown class of neurotransmitter–derived lipidoids (NT-lipidoids) as simple and effective carriers for enhanced brain delivery of several BBB-impermeable cargos. Doping the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. Using this brain delivery platform, we successfully delivered amphotericin B (AmB), antisense oligonucleotides (ASOs) against tau, and genome-editing fusion protein (−27)GFP-Cre recombinase into the mouse brain via systemic intravenous administration. We demonstrated that the NT-lipidoid formulation not only facilitates cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination. This class of brain delivery lipid formulations holds great potential in the treatment of central nervous system diseases or as a tool to study the brain function.

US scientists create ‘friction-free’ material

Scientists at the US Department of Energy’s Argonne National Laboratory have found a way to use diamonds and graphene to create a new material combination that demonstrates so-called superlubricity.

Led by nanoscientist Ani Sumant of Argonne’s Center for Nanoscale Materials (CNM) and Argonne Distinguished Fellow Ali Erdemir of Argonne’s Energy Systems Division, the Argonne team combined diamond nanoparticles, small patches of graphene, and a diamond-like carbon material to create superlubricity, a highly-desirable property in which friction drops to near zero.

According to Erdemir, as the graphene patches and diamond particles rub up against a large diamond-like carbon surface, the graphene rolls itself around the diamond particle, creating something that looks like a ball bearing on the nanoscopic level.

Invention offers new option for monitoring heart health

An invention may turn one of the most widely used materials for biomedical applications into wearable devices to help monitor heart health.

A team from Purdue University developed self-powered wearable triboelectric nanogenerators (TENGs) with polyvinyl alcohol (PVA)-based contact layers for monitoring cardiovascular health. TENGs help conserve and turn it into power.

The Purdue team’s work is published in the journal Advanced Materials.

IBM Seriously Just Turned an Atom Into The World’s Smallest Hard Drive

Circa 2017

Data storage technology continues to shrink in size and grow in capacity, but scientists have just taken things to the next level — they’ve built a nanoscale hard drive using a single atom.

By magnetising an atom, cooling it with liquid helium, and storing it in an extreme vacuum, the team managed to store a single bit of data (either a 1 or a 0) in this incredibly miniscule space.

Not enough room for your holiday photos then, but according to the team from IBM Research in California, this proof-of-concept approach could eventually lead to drives the size of a credit card that could hold the entire iTunes or Spotify libraries, at about 30 million songs each.

Improved Advanced Energy Storage Using New Nano-Engineering Strategy

New types of cathodes, suitable for advanced energy storage, can be developed using beyond-lithium ion batteries.

The rapid development of renewable energy resources has triggered tremendous demands in large-scale, cost-efficient and high-energy-density stationary energy storage systems.

Lithium ion batteries (LIBs) have many advantages but there are much more abundant metallic elements available such as sodium, potassium, zinc and aluminum.

Fastest spinning object in the world hits 300 billion rpm

Circa 2018

Back in July 2018, researchers at Purdue University created the world’s fastest-spinning object, which whipped around at 60 billion rpm – and now that seems like the teacup ride at Disneyland. The same team has now broken its own record using the same technique, creating a new nano-scale rotor that spins five times faster.

Like the earlier version, the whirling object in question is a dumbbell-shaped silica nanoparticle suspended in a vacuum. When it’s set spinning, this new model hit the blistering speed of over 300 billion rpm. For comparison, dentist drills are known to get up to about 500,000 rpm, while the fastest pulsar – which is the speediest-spinning known natural object – turns at a leisurely 43,000 rpm.

Setting this record involves shining two lasers at the nanoparticle. One holds it in place, while the other starts it spinning. When the photons that make up light strike an object, they exert a tiny amount of force on it, known as radiation pressure. Normally this force is too weak to have any noticeable effect, but in a vacuum where there’s very little friction record speeds can be reached. That’s the case here, and it also applies to the concept of light sails, which could one day propel spacecraft at high speeds.

Researchers realize nanoscale electrometry based on magnetic-field-resistant spin sensors

A team led by Prof. Du Jiangfeng, Prof. Shi Fazhan, and Prof. Wang Ya from University of Science and Technology of China, of the Chinese Academy of Sciences, proposed a robust electrometric method utilizing a continuous dynamic decoupling technique, where the continuous driving fields provide a magnetic-field-resistant dressed frame. The study was published in Physical Review Letters on June 19.

Characterization of electrical properties and comprehension of the dynamics in nanoscale become significant in the development of modern electronic devices, such as semi-conductor transistors and quantum chips, especially when the feature size has shrunk to several nanometers.

The nitrogen-vacancy (NV) center in diamond—an atomic-scale spin sensor—has shown to be an attractive electrometer. Electrometry using the NV center would improve various sensing and imaging applications. However, its natural susceptibility to the magnetic field hinders effective detection of the electric field.

Magnetic memory states go exponential

In a new study, a group of researchers led by Prof. Lior Klein, from the physics department and the Institute of Nanotechnology and Advanced Materials at Bar-Ilan University, has shown that relatively simple structures can support an exponential number of magnetic states—much greater than previously thought. They have additionally demonstrated switching between the states by generating spin currents. Their results may pave the way to multi-level magnetic memory with an extremely large number of states per cell; it could also have application in the development of neuromorphic computing, and more. Their research appears as a featured article on the cover of a June issue of Applied Physics Letters.

Spintronics is a thriving branch of nano-electronics which uses the spin of the electron and its associated in addition to the electron charge used in traditional electronics. The main practical contributions of spintronics are in magnetic sensing and non-volatile magnetic data storage, and researchers are pursuing breakthroughs in developing magnetic-based processing and novel types of .

Spintronics devices commonly consist of magnetic elements manipulated by spin-polarized currents between stable magnetic states. When spintronic devices are used for storing data, the number of stable states sets an upper limit on capacity. While current commercial magnetic memory cells have two stable magnetic states corresponding to two memory states, there are clear advantages to increasing this number, as it will potentially allow increasing memory density and enable the design of novel types of memory.

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