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Category: life extension – Page 510

Aging Happens

Today, we have a talk by Dr. Alvaro Macieira-Coelho, who discusses how aging is a consequence of thermodynamics and entropy. Quite simply, aging is the default for most species.

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. The event was focused on bringing the worlds of research and investment in the rejuvenation biotechnology field together and saw a number of talks and panels focused on research and investment.

Dr. Alvaro Macieira-Coelho is a research director at the French National Institute of Health and Medical Research – INSERM. His talk was about how aging is the default behavior and that life is a balance between entropy and the availability of free energy. Essentially, due to the second law, all species progress through changes, and they age as their ability to resist entropy declines.

Reason and Bill Cherman – Investing in Longevity

Here at LEAF, we engage in a wide range of activities in support of the development of rejuvenation biotechnology in order to end age-related diseases. We report the latest news in aging research, attend conferences and give talks, educate, advocate, and fundraise for research projects on Lifespan.io; recently, we implemented the Longevity Investor Network in order to bring startup companies and investors together.

The Longevity Investor Network

The Longevity Investor Network is a group of investors who meet every month and invite young biotech companies working on aging to pitch their ideas. A successful pitch can often mean funding for a new startup company, helping to get its product developed and into clinical trials.

Bioquark Inc. — Real Bodies Milano Exhibit — Ira Pastor

The Real Bodies Milan exhibit has officially opened! (https://www.facebook.com/realbodiesworld/) — Honored to have Bioquark Inc.‘s (www.bioquark.com) research on display, with our partners at HealthQE (www.healthqe.cloud), for the coming seven months in the technologies for Immortality section of the exhibit

Type of Human Monocytes Found to Undergo Senescence

Scientists found out that nonclassical monocites can become senescent.

Scientists from the A*STAR Singapore Immunology Network have discovered that immune cells called nonclassical monocytes undergo cellular senescence, contradicting what was previously thought of them [1].

Abstract

Human primary monocytes comprise a heterogeneous population that can be classified into three subsets based on CD14 and CD16 expression: classical (CD14high/CD16−), intermediate (CD14high/CD16+), and non-classical (CD14low/CD16+). The non-classical monocytes are the most pro-inflammatory in response to TLR stimulation in vitro, yet they express a remarkably high basal level of miR-146a, a microRNA known to negatively regulate the TLR pathway. This concurrence of a pro-inflammatory status and a high miR-146a level has been associated with cellular senescence in other cell types. Hence, we assessed the three monocyte subsets for evidence of senescence, including proliferative status, telomere length, cellular ROS levels, and mitochondrial membrane potential. Indeed, the non-classical subset exhibited the clearest hallmarks of senescence, followed by the intermediate and then the classical subset. In addition, the non-classical subset secreted pro-inflammatory cytokines basally in vitro.

Destroying Misfolded Proteins to Combat Neurodegenerative Diseases

Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer’s, Parkinson’s, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share.

Misfolded proteins cause multiple age-related diseases

Proteins are large, complex molecules that regulate almost everything in our bodies, either directly or indirectly. They do the majority of the work in cells and are critical for the function, regulation, and structure of tissues and organs.

Can supplementation with NMN Increase Longevity?

Recently, we have shown that by administering the NAD+ precursor NMN (Nicotinamide Mononucleotide)in normal drinking water to older mice, NAD+ levels were restored to those normally associated with younger healthy animals. By administering NMN to mice for just one week, our lab demonstrated a robust correction in age-associated metabolic dysfunction and restored muscle mitochondrial function in old mice to levels seen in younger control mice (Gomes et al. 2013).

https://www.lifespan.io/campaigns/can-nmn-increase-longevity…019dfcda6c

Can we live long enough to live forever? Can we discover Immortality? Dr. Aubrey De Grey

Dr. Aubrey De Grey, SENS Foundation, Co-Founder, talks of species that live hundreds of years. We have to understand metabolism and postpone old age.

How can reverse aging by improving repair mechanism. Cells die, and the waste as well as energy byproducts to avoid tissue breakdown with methyl donors.

https://delgadoprotocol.com/product/neuro-insight/#1523582495879-e8979e45-c0bc

Cellular senescence is one phenomenon by which normal cells cease to divide. In their seminal experiments from the early 1960’s, Leonard Hayflick.

Senescent cells increase in many tissues with aging; they also occur in organs associated with many chronic diseases and after radiation or chemotherapy. Senolytics are a class of drugs that selectively eliminate senescent cells.

Cancer cells are immortal, why?

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