Today we bring you an interview with Professor Steve Horvath pioneer of the epigenetic clocks of aging.
Steve Horvath is a Professor of Human Genetics and Biostatistics at UCLA. His research sits at the intersection of biostatistics, bioinformatics, computational biology, cancer research, genetics, epidemiology, epigenomics, machine learning, and systems biology.
Posted in life extension
Aging skin is a major concern for menopausal women – who experience hormone changes – as it affects self-confidence, psychological wellbeing, intimate relationships, and is the one life challenge where women don’t budget. The anti-aging industry, which is worth $50 billion a year, knows this very well!
When women notice more wrinkles, increased sagging, dullness, dryness and feeling less attractive, they usually opt for fillers, Botox, threads, chemical peels, etc. However, the question remains: how long will all of these sustain rapidly aging skin? Scientific evidence suggests that women lose 30% of their collagen content in the first five menopausal years. Recently, it has been proposed that using bioidentical HRT during this critical time of rapid skin aging can hugely prevent menopausal skin aging.
Furthermore, in the European anti-aging market, “skin HRT” is already being used to prevent rapid changes in menopausal skin by targeting oestrogen receptors. “Skin HRT” is used as an anti-aging cosmeceutical, not just to prevent rapid skin aging, but it can be safely used in women where HRT is contraindicated, as it does not absorb systemically.
The aging process is accompanied by a chronic, smoldering background of inflammation that researchers call “inflammaging”. This backdrop of low-grade inflammation contributes significantly to mortality risk in the elderly and has a number of sources.
Today, we are going to take a look at inflammaging and the various known sources that promote this age-related inflammatory condition.
See a close-up of the above image!
UK aging research foundation produces roadmap for the emerging longevity industry in a series of reports to be published throughout the year
Friday, Feb. 2, 2017, London, UK: The Biogerontology Research Foundation has embarked on a year-long mission to summarise in a single document the various emerging technologies and industries which can be brought to bear on aging, healthy longevity, and everything in between, as part of a joint project between The Global Longevity Consortium, consisting of the Biogerontology Research Foundation, Deep Knowledge Life Sciences, Aging Analytics Agency and Longevity. International platform.
For scientists, policy makers, regulators, government officials, investors and other stakeholders, a consensus understanding of the field of human longevity remains fragmented, and has yet to be systematized by any coherent framework, and has not yet been the subject of a comprehensive report profiling the field and industry as a whole by any analytical agency to date. The consortium behind this series of reports hope that they will come to be used as a sort of Encyclopedia Britannica and specialized Wikipedia of the emerging longevity industry, with the aim of serving as the foundation upon which the first global framework of the industry will be built, given the significant industry growth projected over the coming years.
Today, we wanted to bring your attention to a new open access paper. The authors here review the role of cellular senescence in the context of the cardiovascular and metabolic diseases of aging. This paper puts special focus on the aging of the vascular system and the role that accumulating numbers of senescent cells play in that process.
What is cellular senescence?
As the body ages, increasing amounts of cells enter a state of senescence. Senescent cells do not divide or support the tissues of which they are a part; instead, they emit a range of potentially harmful signals known collectively as the senescence-associated secretory phenotype (SASP). Senescent cells normally destroy themselves via a programmed process called apoptosis, and they are removed by the immune system; however, as the immune system weakens with age, increasing numbers of these senescent cells escape this process and build up.
New article in Republican Herald out with #transhumanism for Palm Sunday:
Today is Palm Sunday, the first day of Holy Week. It is a week of great drama, but not of tragedy. A few days after his triumphal entry into Jerusalem, Christ will be crucified. On Easter, the first day of a new week, he will rise from the dead to live eternally.
Belief in this resurrection is the core of Christian faith, and on Easter Christians proclaim, “Oh death, where is thy sting? O grave, where is thy victory?”
These words of hope and faith were written by St. Paul in his first epistle to the Corinthians. Strangely, in 2018, they could also be a rallying cry for transhumanists and life-extenders, atheists in their vast majority.
Harvard reminds the biological clock using NAD+ and NaHS!
Investigators at Harvard Medical School have identified the key cellular mechanisms behind vascular aging and its effects on muscle health, and they have successfully reversed the process in animals.
Could reversing the aging of blood vessels hold the key to restoring youthful vitality? If the old adage “you are as old as your arteries” reigns true then the answer is yes, at least in mice.
According to a new study by Harvard Medical School researchers, they have identified the cellular mechanisms that cause the aging of vascular arteries as well as the effects of such aging on the health of muscles. The Medical team was also able to successfully reverse this aging process.
This spring happens to be rich with events promoting research on aging. Just one month after the Undoing Aging conference, jointly organized by the SENS Research Foundation and the Forever Healthy Foundation, we are expecting yet another visionary event in Kazan, Russia that might prove to be another great gift to our community.
Supervised by one of the most active proponents of aging research in Russia, RAS Correspondent Member Dr. Alexey Moskalev, the fifth international Interventions to Extend Healthspan and Lifespan conference will be held in Kazan on April 23–25, 2018.
The conference will gather brilliant scientists from all over the world in one place. To make it more comfortable for international guests, an English translation will be provided for all talks.
