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Category: life extension – Page 509

Type of Human Monocytes Found to Undergo Senescence

Scientists found out that nonclassical monocites can become senescent.

Scientists from the A*STAR Singapore Immunology Network have discovered that immune cells called nonclassical monocytes undergo cellular senescence, contradicting what was previously thought of them [1].

Abstract

Human primary monocytes comprise a heterogeneous population that can be classified into three subsets based on CD14 and CD16 expression: classical (CD14high/CD16−), intermediate (CD14high/CD16+), and non-classical (CD14low/CD16+). The non-classical monocytes are the most pro-inflammatory in response to TLR stimulation in vitro, yet they express a remarkably high basal level of miR-146a, a microRNA known to negatively regulate the TLR pathway. This concurrence of a pro-inflammatory status and a high miR-146a level has been associated with cellular senescence in other cell types. Hence, we assessed the three monocyte subsets for evidence of senescence, including proliferative status, telomere length, cellular ROS levels, and mitochondrial membrane potential. Indeed, the non-classical subset exhibited the clearest hallmarks of senescence, followed by the intermediate and then the classical subset. In addition, the non-classical subset secreted pro-inflammatory cytokines basally in vitro.

Destroying Misfolded Proteins to Combat Neurodegenerative Diseases

Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer’s, Parkinson’s, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share.

Misfolded proteins cause multiple age-related diseases

Proteins are large, complex molecules that regulate almost everything in our bodies, either directly or indirectly. They do the majority of the work in cells and are critical for the function, regulation, and structure of tissues and organs.

Can supplementation with NMN Increase Longevity?

Recently, we have shown that by administering the NAD+ precursor NMN (Nicotinamide Mononucleotide)in normal drinking water to older mice, NAD+ levels were restored to those normally associated with younger healthy animals. By administering NMN to mice for just one week, our lab demonstrated a robust correction in age-associated metabolic dysfunction and restored muscle mitochondrial function in old mice to levels seen in younger control mice (Gomes et al. 2013).

https://www.lifespan.io/campaigns/can-nmn-increase-longevity…019dfcda6c

Can we live long enough to live forever? Can we discover Immortality? Dr. Aubrey De Grey

Dr. Aubrey De Grey, SENS Foundation, Co-Founder, talks of species that live hundreds of years. We have to understand metabolism and postpone old age.

How can reverse aging by improving repair mechanism. Cells die, and the waste as well as energy byproducts to avoid tissue breakdown with methyl donors.

https://delgadoprotocol.com/product/neuro-insight/#1523582495879-e8979e45-c0bc

Cellular senescence is one phenomenon by which normal cells cease to divide. In their seminal experiments from the early 1960’s, Leonard Hayflick.

Senescent cells increase in many tissues with aging; they also occur in organs associated with many chronic diseases and after radiation or chemotherapy. Senolytics are a class of drugs that selectively eliminate senescent cells.

Cancer cells are immortal, why?

Continue reading “Can we live long enough to live forever? Can we discover Immortality? Dr. Aubrey De Grey” | >

Reversing Aging Update

Celebrate Unlimited Life Spans and a presentation by Bill Faloon on Human Age Reversal.
Bill Faloon will give an update on Age Reversal, similar to a presentation that he shared at RAAD Fest 2018!

Bill Faloon compiled the 1,500-page medical reference book Disease Prevention and Treatment, and his latest book is Pharmocracy: How Corrupt Deals and Misguided Medical Regulations Are Bankrupting America—and What to Do About It. He is also Director and Co-founder of the Life Extension Foundation.

To promote Life Extension’s innovative medical concepts, Bill has been featured in hundreds of media appearances including The Phil Donahue Show, The Joan Rivers Show, Tony Brown’s Journal, ABC News Day One, and Newsweek magazine.

Church of Perpetual Life, a science-based church is open to people of all faiths & belief systems. We are non-denominational & non-judgmental and a central gathering place of Transhumans. What unites us is our common faith, belief, and desire in Unlimited Life Spans.

Are You Sure Eighty Years Are Enough?

Sometimes, people say that around 80 years of life will be enough for them, but have they thought it through?

When asked how long they want to live, people often say no more than ten years above their country’s average lifespan. This, mind you, is in a world where aging is still inevitable; people know they won’t be in top shape during those ten extra years, and yet, perhaps hoping they might be an exception to that rule, they still wish they could get that little extra time. Even when told that they will live these extra years in complete health, the most common choice is the current maximum recorded human lifespan, which is roughly 120 years.

If we assume that no rejuvenation therapies are available to extend the time you spend in youthful health, then it is somewhat understandable if you don’t feel up for a very long life, because the odds are that its final decades will be increasingly miserable ; however, if rejuvenation therapies were available, and you could be fully healthy for an indefinite time, why stop at 120 years? Life extension advocates have probably all had their fair share of conversations with people who insist that 80-odd years will be more than enough for them, health or no health—worse still, some don’t care about preserving their health precisely because they think that 80 years is a sufficiently long time to live.

How long one wants to live is only his or her business; just like no one should have the right to force other people to live no longer than the current maximum (an imposition that would indirectly result from a hypothetical ban on life extension therapies), no one should have the right to force anyone else to live longer than 80 years, if that’s what he or she wishes for whatever reason. Indeed, it’s not the right to die when you see fit that’s at issue here; the question is whether people who claim that 80 years are enough have seriously thought the matter through before making their minds up or are simply parroting what others typically say out of social pressure.

Fisetin Found in Strawberries Clears Senescent Cells in Mice

Today, we want to bring your attention to a recent mouse study on fisetin, a commonly available supplement that has proven effective at destroying senescent cells.

What are senescent cells?

As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known as apoptosis and are disposed of by the immune system. Unfortunately, as we age, the immune system declines, and increasing numbers of senescent cells escape apoptosis and accumulate in the body.