A pre-print study reveals that young blood plasma given to older mice reduced aging by an average of 54% across multiple tissues; and had an impact on other signs of aging, such as cellular senescence, fat accumulation, and behavioural measures.

“We’ve wondered if it might be possible to simply rewind the aging clock without inducing pluripotency,” said Vittorio Sebastiano, assistant professor at Stanford University and senior author of the Nature Communications article. “Now we’ve found that tightly controlling the exposure to these proteins can promote rejuvenation in multiple human cell types, including stem cells. This has profound implications for regeneration and restoration of cell functionality of aged tissues.”

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MOUNTAIN VIEW, Calif., March 25, 2020 /PRNewswire/ — A study published in the respected Nature Communications journal highlights the promise of technology being developed by Turn Biotechnologies to treat age-related health conditions.

The study by researchers at the Stanford University School of Medicine found that old human cells can be induced into a more youthful and vigorous state when they are exposed to a rejuvenating treatment that triggers the limited expression of a group of proteins known as Yamanaka factors, which are important to embryonic development.

An international team of scientists, led by University of Helsinki reported that vitamin B3, niacin, has therapeutic effects in progressive muscle disease. Niacin delayed disease progression in patients with mitochondrial myopathy, a progressive disease with no previous curative treatments.

Vitamin B3 forms have recently emerged as potent boosters of energy metabolism in rodents. These vitamins are precursors for NAD⁺, a molecular switch of metabolism between fasting and growth modes.

As fasting has been shown promote health and longevity in for example mice, a variety of “NAD boosters” are being developed. However, whether actual NAD⁺ deficiency exists in human disease, and whether NAD⁺ boosters could have curative effects in patients with degenerative diseases, has remained elusive.

Ira Pastor, ideaXme life sciences ambassador, interviews Dr. Mark Wolff, Morton Amsterdam Dean, and Professor, Division of Restorative Dentistry, at the University of Pennsylvania, School of Dental Medicine.

Ira Pastor Comments:

So as frequent listeners of the ideaXme show know, we spend a lot of time talking about the theme of “healthy aging”, and the reality that aging, and related biological changes associated with aging, occur across all of the body’s cells, tissues, and organs, and these changes affect all structure and function of the body, including the teeth and gums, and as such, oral health is the focus of our show today.

The underlying processes of biological aging can dramatically affect oral health and many of the specific changes that occur over time in our bodies as we age (such as cells renewing at a slower rate, tissues become thinner and less elastic, bones become less dense and strong, our immune system become weaker, such that infection can occur more quickly and wound healing takes longer), can have major impact in the oral cavity (affecting tissue and bone in the mouth), as well as trickle down effects on the rest of the body.

Oral health problems in older adults include, but are not limited to: untreated tooth decay, gum disease, tooth loss, oral cancer, as well as exacerbated chronic disease associated with various co-morbid conditions and physiologic changes associated with aging (e.g., hypertension, diabetes mellitus).

Dr. Mark Wolff:

A team of scientists successfully achieved 53% reverse aging in old rats with blood plasma from young rats, in an astounding leap forward for the erstwhile-controversial aging field of study.

An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells.

The study, published in the peer-reviewed journal Cell Stem Cell, identified various cell types present in skeletal muscle tissues, from early embryonic development all the way to adulthood. Focusing on muscle progenitor cells, which contribute to muscle formation before birth, and muscle stem cells, which contribute to muscle formation after birth and to regeneration from injury throughout life, the group mapped out how the cells’ gene networks—which genes are active and inactive—change as the cells mature.

The roadmap is critical for researchers who aim to develop muscle stem cells in the lab that can be used in regenerative cell therapies for devastating muscle diseases, including muscular dystrophies, and sarcopenia, the age-related loss of muscle mass and strength.