Had a very frank discussion with Greg Mustreader about transhumanism, learned helplessness of society in the face of aging and death, insufficient sense of urgency among researchers of aging, epigenetic rejuvenation, cryonics, and so on. No filter! đ.
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Researchers have discovered that the powerhouses of our cells, the mitochondria, also play a role in triggering cells to enter senescence, a dormant state in which cells cease to divide and begin to shut down, ready to die.
Mitochondria trigger cytoplasmic chromatin and inflammation
The new study shows that the mitochondria in each cell communicate with its nucleus, causing it to shut down and enter a senescent state [1]. Dr. Peter Adams, one of the studyâs researchers, has spent over a decade investigating how chromatin clusters, a mixture of DNA and proteins typically encountered in the cell nucleus, actually leak out of the nucleus and into the cytoplasm in senescent cells. This leaking then triggers a cascade of inflammatory signals, which are linked to the onset of various age-related diseases.
Kingâs College in London, UK has been awarded a grant to investigate the role of senescent cells, which accumulate as we age, in the context of the heart and how using a therapy to remove them influences its ability to recover from injury.
What are senescent cells?
As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby healthy cells to enter the same senescent state. Their presence causes many problems: they reduce tissue repair, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related diseases.
In my previous post âCryonics for uploaders: WTF is consciousness?â I didnât elaborate on the spiritual implications of emerging theories of consciousness and reality. Hereâs a unified theory of consciousness, physics, Deity, reincarnation, afterlife, eschatology, and theo/technological resurrection wink
Do you want to stop ageing? Do you want to live forever? Can science help you cheat death? In this pioneering documentary, Professor Rose Anne Kenny takes us through the science and the consequences of living longer lives.
Imagine for a moment that old age became a thing of the past. Today, for better or for worse, it would appear that eternal life may soon be a reality. Some scientists are forecasting that the only way many humans will die is if they are shot or run over by a bus.
The programme unveils what is happening in age prevention, shows how we can lengthen our own lifespans and explains how some scientists now believe we are closer than ever to finding the Elixir of Life.
Such power over life itself poses many profound questions: what impact is it going to have on our societies? What preparations should our governments be making for an ever-ageing population? Do people really want to live longer and suffer the inevitable weakening of their capacities? And is it morally right to transcend human fallibility and assume the role of God?
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By definition, posthumanism (I choose to call it âcyberhumanismâ) is to replace transhumanism at the center stage circa 2035. By then, mind uploading could become a reality with gradual neuronal replacement, rapid advancements in Strong AI, massively parallel computing, and nanotechnology allowing us to directly connect our brains to the Cloud-based infrastructure of the Global Brain. Via interaction with our AI assistants, the GB will know us better than we know ourselves in all respects, so mind-transfer, or rather âmind migration,â for billions of enhanced humans would be seamless, sometime by mid-century.
I hear this mantra over and over again â we donât know what consciousness is. Clearly, thereâs no consensus here but in the context of topic discussed, I would summarize my views, as follows: Consciousness is non-local, quantum computational by nature. Thereâs only one Universal Consciousness. We individualize our conscious awareness through the filter of our nervous system, our âlocalâ mind, our very inner subjectivity, but consciousness itself, the self in a big sense, our âcoreâ self is universal, and knowing it through experience has been called enlightenment, illumination, awakening, or transcendence, through the ages.
Any container with a sufficiently integrated network of information patterns, with a certain optimal complexity, especially complex dynamical systems with biological or artificial brains (say, the coming AGIs) could be filled with consciousness at large in order to host an individual âreality cell,â âunit,â or a ânodeâ of consciousness. This kind of individuated unit of consciousness is always endowed with free will within the constraints of the applicable set of rules (âphysical lawsâ), influenced by the larger consciousness system dynamics. Isnât too naĂŻve to presume that Universal Consciousness would instantiate phenomenality only in the form of âbioâ-logical avatars?
A BONKERS Russian billionaire claims heâll make you immortal by 2045.
Internet businessman Dmitry Itskov, 38, is bankrolling a far-fetched plan to uploaded peopleâs personalities to artificial brains.
These âbrainsâ can then be jammed into robots or holograms, allowing us to live on forever as artificial versions of ourselves, Dmitry claims.
If you canât defeat death, what if you could postpone it, or at least postpone the diseases commonly associated with getting old? Many people, especially the ultra-wealthy in Silicon Valley, are investing money into companies trying to answer exactly those questions.
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How the ultra rich are trying to live forever.
Lifespan.io is hosting its third annual conference on aging and rejuvenation biotechnology.
The Life Extension Advocacy Foundation/Lifespan.io, a nonprofit company promoting aging research, is hosting its third annual Ending Age-Related Diseases: Investment Prospects and Advances in Research conference on August 20â21 at the Stern Auditorium of the Icahn School of Medicine at Mount Sinai (New York City, USA).
The goal of this conference is to promote scientific and public discussion in order to foster the development of interventions that target aging and are capable of relieving our aging society from the burden of age-related diseases. Key topics of the conference include biomarkers of aging, discoveries in fundamental research, the development of interventions targeting the root mechanisms of aging, investment strategies, and regulatory issues that are relevant to rejuvenation research.