Posted in life extension
There’s only a few days left before our second conference in New York City takes place, and June has brought a lot of exciting news, such as the results of UNITY’s senolytic human trial, as well as a number of episodes of LifeXtenShow, our new YouTube show that is now a little over a month old already. Let’s dig into the details!
LEAF News
It’s called cognitive reserve, and it’s the phenomenon of the mind’s resistance to damage of the brain. It’s also the subject of not only an upcoming new data and biomedical sample resource, but also a related request for information (RFI) from the NIA and a first-of-its-kind workshop in September.
The push to study cognitive reserve in more depth across the scientific disciplines was born out of recommendations from the Cognitive Aging Summit III. Some 300 researchers attended the summit in Bethesda, Maryland in 2017. Coordinated by the NIA of the National Institutes of Health (NIH) and supported by the McKnight Brain Research Foundation, the summit centered on age-related brain and cognitive changes, with a particular focus on issues related to cognitive resilience and reserve. According to the NIA, investigators from around the world delivered presentations and engaged in discussion “about some of the most important scientific questions relating to the biological, physiological, social and behavioral aspects of reserve and resilience in aging individuals. Attendees also discussed strategies to preserve and bolster cognitive function during aging.”
Advance could mean ‘affordable off-the-shelf therapy’ to treat age-related macular degeneration, the leading causes of sight loss in the UK.
We’re now rapidly approaching a pivotal moment in the history of this planet, when through scientific discovery an intelligent species could become a race of demigods, THE RACE OF THE IMMORTALS.
It’s quite achievable now. In fact, that will probably happen in two stages: First stage — we have to extend our lifespan with ever-improving Biotechnology. Aging is declared a desease, and around 2029, with the advances in Nanotechnology and Artificial Intelligence, we will be able start to reverse aging and add more than one year every year to an average life expectancy.
So if you’re alive in 2030, chances are you’ll live to 100 and beyond. What life would be like on the other side, when you know you can live indefinitely long? Well, we’ll get used to it and adjust accordingly. We’ll merge into the Global Brain, and emerge as the Global Mind.
To the scientists here, could humans live for 300 years?
Those portions of the modern longevity community interested in bringing an end to aging and extending healthy human life span indefinitely tend to be the older portions, people who have been a part of the broader movement for quite some time. Newcomers tend to be more moderate, aiming at lesser goals. Perhaps this is a result of the successful projects, such as the SENS Research Foundation and Methuselah Foundation, tending to moderate their rhetoric as they attract a broader and larger base of support. I think that this road to moderation might be a problem, and that there is thus a continued role for those who loudly declaim that the goal is to control aging absolutely, via new medical technology, and that the natural consequence of that control is healthy, active, youthful life that extends for centuries or more.
If the goals that our movement works towards are broadly watered down from radical life extension of centuries to just adding a few more years, then marginal projects that can do no more than add a few more years will come to dominate the field to the exclusion of everything else. We are already more or less in this situation, in that the vast majority of funding goes towards discovery and development of small molecules that tinker with the operation of an aged metabolism to make it a little more resilient to the underlying causes of aging. If that is all that is done, then we’ll all age and die on basically the same schedule as our parents and grandparents. It will be a grand waste of opportunity, given that we have the knowledge and the means to do far better, such as by following the SENS agenda for rejuvenation biotechnologies based on repairing the root causes of aging.
A new mouse study highlights the proteins responsible for LC3-associated endocytosis (LANDO), an autophagy process that is involved in degrading β-amyloid, the principal substance associated with Alzheimer’s disease.
Proteostasis
Proteins in the human brain can form misfolded, non-functional, and toxic clumps known as aggregates. Preventing these aggregates from forming, and removing them when they do, is a natural function of the human body, and it is known as proteostasis. However, as we age, this function degrades, and loss of proteostasis is one of the hallmarks of aging. The resulting accumulation of aggregates leads to several deadly diseases, one of which is Alzheimer’s.
Aging is just natural, while rejuvenation therapies aren’t, but does this mean we should accept aging as it is and forget about rejuvenation? Not at all, and as Nicola explains in this video, just because something is natural, it’s not also automatically good for you.
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https://www.leafscience.org/ending-age-related-diseases-adva…ects-2019/
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https://www.eventbrite.com/e/ending-age-related-diseases-201…3207520125
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At 100 years old, the world’s oldest billionaire would be forgiven for taking it easy and enjoying the riches of his eight-decade career.
But for Chang Yun Chung, founder of Pacific International Lines (PIL), staying at home isn’t an option. Despite handing over the role of executive chairman to his son, Teo Siong Seng, earlier this year, the centenarian Singaporean insists on going into the office every day.
“It’s my habit,” Chang told CNBC in a recent episode of “Managing Asia.”
Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.
More than 80 million men, women and children in the United States experience hair loss. Genetics, aging, childbirth, cancer treatment, burn injuries and medical disorders such as alopecia can cause the condition. Hair loss is often associated with emotional distress that can reduce quality of life and lead to anxiety and depression.
“Our new protocol described today overcomes key technological challenges that kept our discovery from real-world use,” says Alexey Terskikh, Ph.D., an associate professor in Sanford Burnham Prebys’ Development, Aging and Regeneration Program and the co-founder and chief scientific officer of Stemson Therapeutics. “Now we have a robust, highly controlled method for generating natural-looking hair that grows through the skin using an unlimited source of human iPSC-derived dermal papilla cells. This is a critical breakthrough in the development of cell-based hair-loss therapies and the regenerative medicine field.”
