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Category: life extension – Page 381

Liz Parrish and Dr. Sewell at the Coalition for Radical Life Extension Webinar (April 2020)

Liz Parrish, founder and CEO of BioViva USA Inc., together with Dr. Sewell from Integrated Health Systems (IHS), interviewed by James Strole, Director of the Coalition for Radical Life Extension (CRLE) and Co-Founder of People Unlimited Inc., and Joe Bardin, Communications Director of the CRLE.
The interview took place on April 25, 2020.

The Coalition of Radical Life Extension are de producers of the anual event RAADfest (Revolution Against Aging and Death Festival) which will take place this year in Las Vegas, October 1 — 4. I highly recommend you consider attending this event so take a look at https://www.raadfest.com/

To watch the entire webinar for free visit the following link: https://www.rlecoalition.com/webinar

Other related links:
Coalition of Radical Life Extension: https://www.rlecoalition.com/
BioViva: https://biovivascience.myshopify.com/
Integrated Health Systems (IHS): https://www.integrated-health-systems.com/

Join me at any of my media channels:
Youtube: https://www.youtube.com/andresgrases
: https://www.linkedin.com/in/andresgrases/
: https://www.facebook.com/
Instagram: https://www.instagram.com/andgrabri/

Also, visit my own website here: https://transhumanplus.com/

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Reversing Ageing: New Studies Show it Can be Done

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NMN Restores Brain Function

A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major factor in the age-related decline of cognitive and motor functions, this discovery presents exciting new possibilities for longevity research.

Neurovascular coupling

While the human brain is the evolutionary advantage that brought us to where we are today, operating this machine requires considerable resources. Our cerebral blood flow (CBF) accounts for 15% of cardiac output and 20% of resting total oxygen consumption, even though the brain itself comprises just 2% of body mass. CBF has to be constantly redirected to the regions of the brain that are currently active, and NVC is the mechanism in charge of this complex operation. Importantly, the CBF/cardiac output ratio decreases with age [2].

Molecules identified that reverse cellular aging process

Central to a lot of scientific research into aging are tiny caps on the ends of our chromosomes called telomeres. These protective sequences of DNA grow a little shorter each time a cell divides, but by intervening in this process, researchers hope to one day regulate the process of aging and the ill health effects it can bring. A Harvard team is now offering an exciting pathway forward, discovering a set of small molecules capable of restoring telomere length in mice.

Telomeres can be thought of like the plastic tips on the end of our shoelaces, preventing the fraying of the DNA code of the genome and playing an important part in a healthy aging process. But each time a cell divides, they grow a little shorter. This sequence repeats over and over until the cell can no longer divide and dies.

This process is linked to aging and disease, including a rare genetic disease called dyskeratosis congenita (DC). This is caused by the premature aging of cells and is where the team focused its attention, hoping to offer alternatives to the current treatment that involves high-risk bone marrow transplants and which offers limited benefits.

Restoring Telomerase Activity in Telomere Biology Diseases

Researchers have demonstrated that it is possible to restore telomerase activity in stem cells affected by telomere biology diseases, which prevent them from producing telomerase and repairing their telomeres.

Telomeres and telomerase

Each chromosome that stores our genetic information has a protective cap at each end known as a telomere, a specific DNA sequence that is repeated thousands of times. This sequence has two purposes: it protects the coding regions of the chromosome and prevents it from being damaged, and it acts as a clock that controls the number of replications a cell can make; this is known as the Hayflick limit.

Refining Senolytic Drugs to Be Less Toxic and More Effective

Researchers have developed a way to modify an existing cancer drug with toxic side effects into something that is less toxic to blood platelets and more effective at removing harmful and inflammatory senescent cells, one of the reasons we age, from mice.

What are senescent cells?

As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby healthy cells to enter the same senescent state. Their presence causes many problems: they reduce tissue repair, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related diseases.

IMMORTALISTS MAGAZINE’s 4th PUBLICATION!

Dinorah Delphin has unveiled another magnificent issue of the Immortalists Magazine. She has clearly focused her contributing authors on the world pandemic, with impressive results.

One of the outstanding articles is from our pal, the Chairman of the USTP, Gennady Stolyarov. Gennady levels an eviscerating attack on the American health care system.

I can see that Gennady has a visceral reaction to mass death. There is passionate, broiling anger in the lines of his article. He seems to be mounting a crusade, and I’m going to confess that I’m considering arming myself for battle.

“…there has not been the will…to prioritize public health and longevity as the overarching objective of the economy and of society.”

People have amazingly short attention spans. And you might think, after looking back at previous epidemics, that shortly after this subsides that everyone will go back to debating trivia on TV and quibbling over the latest inanities bellowed from the podium by the oompa loompa moron. After all are there vaccines for SARS, MERS, or HIV? No, there are not. It takes will and effort and money and focus and time to create an effective vaccine. I understand that the world record quickest vaccine development was for the mumps and that that effort took 4 years. However, this virus may have a second and a third wave coming, which might function as a nightmare wake-up alarm that can’t be shut off. There is the potential that at some point the mountainous pile of dead bodies will actually focus this nation’s attention on delivering a lasting solution. I credit Gennady for having the foresight to immediately engage the USTP in a series of proposals designed to enable that lasting solution.

What would our world look like if the number one priority was making everyone healthy enough to live forever?

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How to live when nobody dies

Three score and ten is so 1970s. Today, the average baby born in the UK will live long enough to see the beginning of the 22nd century. Increasingly we also hear claims of longevity breakthroughs that could propel those children – and maybe even their parents – into triple digits and beyond. Is eternal life something we want outside of science fiction? And how will society cope if it is?

“The first ten million years were the worst,” said Marvin. “The second ten million years, they were the worst, too. The third ten million years I didn’t enjoy at all. After that I went into a bit of a decline.”

So opines Marvin, Douglas Adams’ paranoid android, who follows the protagonists of ‘The Hitchhiker’s Guide to the Galaxy’ around like a bumbling, grumbling storm cloud. Functionally immortal (and cursed with a “brain the size of a planet”), Marvin is the hubristic dream of eternal life printed and stamped in circuitry. While his human shipmates stumble from one disaster to another, devoting their limited talents to avoiding death at all costs, Marvin plods glumly along, bemoaning the pointlessness of an infinite existence in which there is nothing new to learn, no challenge to his intellect and in which everyone – even his closest friend, a rat that nested for a time in his foot – dies. Except him.

Can Aging be Reversed? Solving the Aging Problem

A transcript for this episode is available online in blog form at Transcript: Aubrey de Grey Interview on Solving the Aging Problem.

Imagine a world where we live to 130, 150 or 500 years old. Anti-aging pioneer, Dr. Aubrey de Grey, joins us to share his confidence in how technology will dramatically extend human lifespan. He joins our host, Heather Sandison, ND, to look at aging as a problem to be solved. In this episode, Dr. Aubrey de Grey offers hope to people looking for cutting-edge therapies to live longer. We discuss:

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