“What you see in these diseases of aging is often the sort of unintended consequences of a system that was absolutely awesome for the young, at the expense of the old.” — Ned David.
Category: life extension – Page 380
Battling Parkinson’s disease
Who has heard of mitochondrial medicine?
“We know that increased rates of mtDNA mutation cause premature aging,” said Bruce Hay, Professor of biology and biological engineering at the California Institute of Technology. “This, coupled with the fact that mutant mtDNA accumulates in key tissues such as neurons and muscle that lose function as we age, suggests that if we could reduce the amount of mutant mtDNA, we could slow or reverse important aspects of aging.”
This brings us to the second major development relevant to mitochondria in disease — that genetic technology is now at a point where the targeted removal of the problem mitochondrial genes can become the basis for clinical intervention. This is the implication of research that Hay and colleagues both at Caltech and the University of California at Los Angeles described in a paper published in the journal Nature Communications.
Fixing body tissues by knocking out genes that prevent bad mitochondrial from being ousted in a timely fashion might sound like science fiction, but that’s where things are going and it’s part of a growing trend of what’s being described as mitochondrial medicine.
Nanodevices Track Cells From the Inside, Show How They Develop With Time
For the first time, scientists have added microscopic tracking devices into the interior of cells, giving a peek into how development starts.
For the first time, scientists have introduced minuscule tracking devices directly into the interior of mammalian cells, giving an unprecedented peek into the processes that govern the beginning of development. This work on one-cell embryos is set to shift our understanding of the mechanisms that underpin cellular behavior in general, and may ultimately provide insights into what goes wrong in aging and disease. The research, led by Professor Tony Perry from the Department of Biology and Biochemistry at the University of Bath, involved injecting a silicon-based nanodevice together with sperm into the egg cell of a mouse. The result was a healthy, fertilized egg containing a tracking device. The tiny devices are a little like spiders, complete with eight highly flexible ‘legs’.
Bill Faloon — If Nothing Else Kills Us, Aging Will (Longevity #005)
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SHOW NOTES TIME STAMPS:
0:00 Sneak Peak & Longevity Team Intro
2:08 Bill Faloon Intro: https://lifeextension.com & https://age-reversal.net
3:00 Life extension inspiration
3:35 Challenge death norm, …” I am not going to let that happen…”
4:39 Safety in life extension medication
4:58 Metformin Safety
6:58 “FDA is an incompetent and corrupt federal bureaucracy”
8:35 Berberine alternative for Metformin?
10:20 Metformin role in AMPK enzyme
11:30 AMPK activation in intermittent fasting?
12:00 Bill Faloon personal experience with Metformin
14:30 “…Take Care of yourself today…” by getting annual blood tests to test for lipids, glucose, etc.
15:05 Optimized sleep strategies
17:27 Insomnia
18:20 Blue light exposure graphic
18:50 Watch Brent’s interview with The Sleep Doctor, Micael Brues: https://youtube.com/watch?v=7af2AAjL4b4&t=662s
20:13 Removing anxiety strategies for better sleep
22:04 Human age reversal project clinical trial update
24:50 Exosomes — Watch Brent’s interview with Kimera Labs exosomes CEO/founder Dr. Duncan Ross: https://youtube.com/watch?v=X8eIxo3eqvQ&t=10s
26:30 IF NOTHING ELSE KILLS US, AGING WILL
27:15 Subscribe to The Church of Perpetual Life YouTube channel: https://www.youtube.com/COPL18
28:45 TAME trial for Metformin https://ncbi.nlm.nih.gov/pmc/articles/PMC5943638
29:58 Dr. Nir Barzilai
33:01 Metformin not illegal for doctors to prescribe
34:01 Intermittent fasting benefits
34:46 autophagy
35:59 Is coffee bad for telomeres?
37:01 All types of coffee containing roasted beans contain some acrylamide
37:28 Chlorophyllin to guard against acrylamide
37:55 Watch Brent’s interview with Bill Faloon https://youtube.com/watch?v=sKjHJE8x1bs
38:08 History and future of The Church Of Perpetual Life
40:20 Dr. Aubrey de Grey connected Bill Faloon with Neal Francis Vanderee to start The Church of Perpetual Life! Watch Brent’s interview with Aubrey https://youtube.com/watch?v=TquJyz7tGfk&t=365s
42:10 Religion and afterlife argument for life extension & immortality
43:35 Bill says Dr. George Church feels all viruses may just disappear in next 3–4 years and aging may be vanquished in next 10 years
44:10 Quantum Archeology “…Quantum computer technology that will ultimately be our road to physical immortality. “
45:23 Nikolai Fyodorov’s view of how “Mankind was created to find a way to achieve abundant immortality”
46:52 Why do you want to live forever?
49:01 Do the impossible!
51:00 How can all of us contribute to this life extension movement?
52:28 Why religion, immortality and living a long life are already connected
55:02 Simulation theory
55:45 Rate of how fast technology is improving
58:51 Diet food recommendations
1:00:03 Dr. Eric Berg YouTube: What Really Happens When We Fast? https://youtube.com/watch?v=vhmtoAYVRSo
1:01:42 Death anxiety
1:05:20 Bill Faloon’s influence on his kids and their work
1:09:01 Longevity benefits of having kids
1:09:48 fetal stem cells
1:11:13 Clinical trial update & where to get tested
1:13:34 Bill Faloon’s most important advice
1:15:30 Figure out your chronotype https://thepowerofwhenquiz.com
1:16:18 Brain health tips: Lithium, blueberries, CoQ10 (Ubiquinol)
1:18:55 Conclusion
First Ever Anti-Ageing Gene Discovered in a Secluded Amish Family
Circa 2017 face_with_colon_three
For the first time, scientists have found a genetic mutation that appears to offer a measure of protection against some of the biological effects of ageing.
And, as far as we know, it looks like the only community in the world known to harbour it is an Old Order Amish community living in Indiana.
The mutation can occur on one or both copies of a gene called SERPINE1. It’s known that when both gene copies are mutated, it can lead to a rare genetic bleeding disorder — and the Amish community in question is susceptible to it.
BRIAN KENNEDY — Reversing Human Aging (#0004)
Sirtuins, telomeres, A.I. experiment with vitamin A and personalized medicine, a bit of everything here.
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Brian Kennedy’s Lab Website:
Solving the space junk problem
Space is getting crowded. Aging satellites and space debris crowd low-Earth orbit, and launching new satellites adds to the collision risk. The most effective way to solve the space junk problem, according to a new study, is not to capture debris or deorbit old satellites: it’s an international agreement to charge operators “orbital-use fees” for every satellite put into orbit.
Dr. Michael R. Rose presents “Biological Immortality is REAL”
Dr. Michael R. Rose is Professor at Department of Ecology and Evolutionary Biology at University Of California, Irvine. His main area of work has been the evolution of aging.
“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov
We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.
Working to Save Lives with Age Reversal Education.
========== Perpetual Life Creed ==========
We believe that all of life is sacred and that we have been given this one life to make unlimited. We believe in our Creator’s divine plan for all of humanity to have infinite lifespans in perfect health and eternal joy, rendering death to be optional.
By following our Gospel we achieve eternal life creating a heaven here on earth.
DNA-repairing enzyme reverses age-related cognitive decline
DNA damage is common to our cells, but when we’re young our bodies can fix it pretty easily. Unfortunately we lose that ability over time, leading to many of the symptoms of aging that we know all too well. A new study from MIT has found that reactivating a certain enzyme improves repair of DNA damage in neurons, which helps Alzheimer’s patients and others with cognitive decline.
Previous studies by the team have shown that an enzyme called HDAC1 seems to be involved in DNA repair in neurons. For the new study, the researchers examined what happens when HDAC1 doesn’t do its job.
The team engineered mice to be deficient in HDAC1, and monitored their health compared to normal mice. Things looked good during the animals’ youth – there were no differences in DNA damage or behavior between the two groups. But as they aged, the decline became clear.