The University of Surrey has built an artificial intelligence (AI) model that identifies chemical compounds that promote healthy aging—paving the way towards pharmaceutical innovations that extend a person’s lifespan.
Category: life extension – Page 377
PulseChain Airdrop Raises $20m for SENS
The SENS Research Foundation has apparently already raised four times its annual income thanks to the PulseChain Airdrop.
The PulseChain airdrop supporting aging research
Richard Heart, the founder of HEX, is about to launch a new cryptocurrency called PulseChain. As part of that launch, he has also arranged an airdrop to give away some of the new cryptocurrency in order to support the SENS Research Foundation (SRF).
Epigenetic Age Reduction Within 8 Weeks: Real Effect Or Statistical Noise?
Paper referenced in the video:
Potential reversal of epigenetic age using a diet and lifestyle.
intervention: a pilot randomized clinical trial.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064200/
Patreon link:
https://www.patreon.com/MichaelLustgartenPhD
Scientists produce first genetically engineered marsupials
We probably at this point should make all animals immortal: 3.
The advance promises to unlock new insights into human biology and disease, aiding in the study of everything from the developing immune system to tissue regeneration to skin cancer.
“Studying biodiversity is not just about exploring the biology of a bunch of interesting organisms, but ultimately for a better understanding of human biology,” developmental biologist and lead study author Hiroshi Kiyonari said via email.
Five years ago, his team began to systematically work out the problem that had so long plagued the opossum field. The first barrier was to collect zygotes (fertilized eggs) at the right time. Ideally, that would be before they began dividing, when they are still a single cell. If you inject CRISPR at this stage, you can be sure all the resulting animals’ cells will carry whatever DNA changes you make. Doing it later can mean some cells but not others will be edited — a less ideal outcome known as mosaicism. Another benefit of collecting fertilized eggs as early as possible is that the shell coat hasn’t had time to thicken.
Clinical Trial: Does Plasma Dilution Delay Aging? | Lifespan News Extra
The human trial of plasma dilution started in Russia last week. The lead researcher is checking how the biomarkers of aging will change in response to 110% plasma replacement during the therapy, and the difference between the group with albumin addition and without albumin. The trial is open to both Russian citizens and people from other countries. It is a hybrid model where part of the expenditures is paid by the volunteers, and part is provided by the patron of the research. This model allowed to get the trial started in record time — less than 9 months from conception to the start date.
The research group wants to test plasmapheresis in combination with other longevity therapies next to see if plasma dilution prior to the other therapy can enhance the results.
Are you interested in longevity news? Come over to https://youtube.com/x10show for more!
Does blood hold the secret to aging? That’s kind of what an ongoing clinical trial in Russia is trying to find out. Previous experiments carried out in aged mice suggest that plasma dilution has positive effects on cognition and neuroinflammation, and now scientists want to see if the procedure can positively impact humans too.
By the way, don’t forget our conference Ending Age-Related Diseases 2021 is coming soon! Follow this link to learn more and get your ticket:
Did you know that there are companies operating today that share the collective goal of resurrecting the dead?
In The Last Generation to Die, we explore the difficult conversation of what is to be done for the elderly who might miss out on the benefits of enhanced longevity. But if these companies somehow achieved their goal, however farfetched, that conversation would become moot.
Would you want to resurrect a lost loved one if given the opportunity?
Our Theory Of Aging & Blood Dilution w/ Saline & Albumin | Drs. Irina & Mike Conboy Interview Ep 1
In this video, Drs Irina and Mike Conboy talk about their theory of why we age and introduce Neutral Blood Exchange, which came from their original parabiosis experiments documented in a 2005 paper.
Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.
Papers mentioned in this video.
Plasma dilution improves cognition and attenuates neuroinflammation in old mice.
https://pubmed.ncbi.nlm.nih.gov/33191466/
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.
https://pubmed.ncbi.nlm.nih.gov/32474458/
Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
https://pubmed.ncbi.nlm.nih.gov/15716955/
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Ancha Baranova
Great exclusive interview by longevity expert, PhD. Professor, Systems Biology. Director, Chronic Metabolic and Rare Diseases Systems Biology Initiative (ChroMe RaDSBIn) facebook.com/LifetimeTrustnet/posts/1021975448543419
Dr. Ancha Baranova interview on longevity and Covid technologies.
She discovered many biomarkers for chronic liver diseases, cancer and other illnesses, a biosynthesis of the melanin in human adipose, two novel properties of cell-free DNA, and a variety of novel functions for known biomolecules.
Brain ‘Noise’ Keeps Nerve Connections Young
The findings, published in Nature Communications, could have important implications for human health: minis have been found at every type of synapse studied so far, and defects in miniature neurotransmission have been linked to range of neurodevelopmental disorders in children. Figuring out how a reduction in miniature neurotransmission changes the structure of synapses, and how that in turn affects behavior, could help to better understand neurodegenerative disorders and other brain conditions.
Summary: Study reveals how miniature release events help to keep neurons intact and preserve motor neuron function in aging insects.
Source: EPFL
Neurons communicate through rapid electrical signals that regulate the release of neurotransmitters, the brain’s chemical messengers. Once transmitted across a neuron, electrical signals cause the juncture with another neuron, known as a synapse, to release droplets filled with neurotransmitters that pass the information on to the next neuron. This type of neuron-to-neuron communication is known as evoked neurotransmission.
However, some neurotransmitter-packed droplets are released at the synapse even in the absence of electrical impulses. These miniature release events — or minis — have long been regarded as ‘background noise’, says Brian McCabe, Director of the Laboratory of Neural Genetics and Disease and a Professor in the EPFL Brain Mind Institute.