Biomedical gerontologist Aubrey de Grey, who’s Chief Science Officer of the SENS Research Foundation, is now predicting a 50% chance that people will begin retaining their youthful state via advanced science and technologies by the year 2036.
This is roughly around the same timeline that The Last Generation to Die is based on. Nailed it (hopefully)!
who’s Chief Science Officer of the SENS Research Foundation, is now predicting a 50% chance that people will begin retaining their youthful state via advanced science and technologies by the year 2036.
This is roughly around the same timeline that The Last Generation to Die is based on. Nailed it (hopefully)!
By 2050, the number of adults over the age of 65 globally will double, reaching a staggering 1.6 billion, with the largest growth in the developing world. This growth will be one of the greatest social, economic, and political transformations of our time, that will impact existing healthcare, government and social systems, that today are largely not inclusive of the ageing population or built to the scale needed to support it.
But we can begin to make investments in our support systems (enabled and scaled by technology) that encompass a coordinated response from governments, society, academia, and the private sector.
A precursor to investing in innovative solutions will be to acknowledge the needs of older adults and identify their caregiving challenges. These are the issues that will inform the solutions agenda.
Following in my recent series on subjects that are all the rage in anti-aging and longevity circles, to help you get a good grasp of the essentials so you can know what all the talk is about, and can make informed judgements rather than just following the herd blindly. This time it is on Metformin. This is a drug widely known as a diabetes drug and it has been in use for a very long time, indeed it is one of the most prescribed drugs there is. Recently it has also been a buzz word in the anti aging/longevity communities following the review of data and with it s mechanism of action, being touted and recommended by a variety of voices in the public domain. But how does it work, and how could it improve longevity? Is it safe? Well, if you want to go into a bit more depth and know all the details, I have put together a video which helps you understand what all the fuss is about. And whatever you are doing, have a great day.
Metformin is very popular in the anti aging paradigm currently so let’s have a look at what it is, what it offers, and what the trade offs are… because, well, it is always wise to have all the data.
In this video I will look at the history of metformin and describe its mechanism of action before delving into the current thoughts on its use as an anti aging supplement and longevity benefits due to its overall health benefits.
If you would like to know more about longevity in general as well as the hallmarks of aging then why not check out this video next.
If you would like to look at the articles and studies mentioned they can be found at these links.
Might interest some, mentions telomeres.
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Aging is a common factor in many diseases. So, what if it were possible to treat them by acting on the causes of aging or, more specifically, by acting on the shortening of telomeres, the structures that protect chromosomes? This strategy is being pursued by the Telomeres and Telomerase Group of the Spanish National Cancer Research Centre (CNIO), which has already succeeded in curing pulmonary fibrosis and infarctions in mice by lengthening telomeres. Now they take a first step towards doing the same with renal fibrosis by demonstrating that short telomeres are at the origin of this disease, which is also associated with aging.
The new study will be published this week in the journal Nature Aging.
Renal fibrosis is the most common cause of kidney failure, a disease that can currently only be treated by dialysis. It is characterized by excessive scarring of the tissue, which hardens and loses its functionality.
But such drugs could face a daunting challenge, since aging is not considered a disease. This means the Food and Drug Administration is unlikely to approve a drug for its anti-aging effects, or as a new use for a licensed drug. Also, pharmaceutical companies probably wouldn’t be inclined to develop drugs for that purpose only.
Drugs that can postpone or prevent the onset of debilitating diseases could enhance longevity and provide enormous societal benefits, geroscientists say.
There is a link to see the entire vid but you have to subscribe.
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Papers referenced in the video:
DNA methylation GrimAge strongly predicts lifespan and healthspan:
https://pubmed.ncbi.nlm.nih.gov/30669119/
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality:
https://pubmed.ncbi.nlm.nih.gov/33211845/
Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies:
Check out “How Watson Works here.”
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IBM has made a series of Watson computer systems so that any company can raise their industries products and services far beyond our human capability. IBM’s Watson was first featured to the public with its historic Jeopardy win over Ken Jennings and Brad Rutter the best human Jeopardy players. At the time, Watson contained 200 million pages of structured and unstructured content in a ninety server computing system with an analytical software IBM designed called DeepQA. Now, the financial markets, medicine, insurance companies, government, engineering, and customer service call centers are employing (buying) Watson is an artificial intelligence system, that can be specifically tailored to any digitized industry and quickly evolve their industries potential.