In this new installment of our series on the highest-mileage Tesla Model X (and one of the highest mileage EVs in the world), we look into battery degradation and replacement on a Tesla with over 400,000 miles.
With over 400,000 miles (650,000 km), it’s one of the highest-mileage electric vehicles in the world and serves as a great case study for the longevity of electric cars, in general, and Tesla vehicles in particular.
This work on one-cell embryos could advance our knowledge of the mechanisms that underpin cellular behaviour in general, and may ultimately provide insights into what goes wrong in aging and disease.
For the first time, scientists have added microscopic tracking devices into the interior of cells, giving a peek into how development starts.
Rapamycin, a drug that has life-extending effects on mice (and possibly dogs and humans), also reverses age-related dental problems in mice. 🦷 Out now in eLife from researchers at The University of Washington School of Dentistry & JAX’s Kaczorowski Lab:
Rapamycin, which has life-extending effects on mice, also reverses age-related dental problems such as periodontitis and regrows bones in the animals.
#Eternal life might not be attainable in the near future, but genetic engineers and doctors are working on new life extension technology. The research could lead to keeping our bodies young, and scientists are developing ways of downloading our brain’s consciousness onto digital media once the body is at the end of its life cycle.
#RT #Documentary offers you in-depth documentary films on topics that will leave no one indifferent. It’s not just front-page stories and global events, but issues that extend beyond the headlines. Social and environmental issues, shocking traditions, intriguing personalities, history, sports and so much more – we have documentaries to suit every taste. RTD’s film crews travel far and wide to bring you diverse and compelling stories. Discover the world with us!
In this fifteenth episode, Liz Parrish shares her quest for radical life extension and details her two completed gene therapies. She describes the regenerative medical tourism available today for increased lifespan and costs. She relates her company’s mission to create a human that regenerates faster than they degenerate. She details her upcoming gene therapies, including upgraded IQ.
Quantified Health, Wellness & Aging is a podcast about the latest products and services, technologies and people — pushing forward a new frontier. The audience is two-fold. Industry professionals who wish to track a trillion-dollar shift and new growth markets. Savvy consumers who wish to stay at the forefront, live longer and in an optimal state. Bimonthly, Lee S Dryburgh hosts a pioneer for an in-depth discussion.
Ira Pastor, ideaXme life sciences ambassador, interviews Dr. Eric Van Gieson, Program Manager in the Biological Technologies Office (BTO) at DARPA. https://www.darpa.mil/staff/dr-eric-van-gieson
Ira Pastor Comments
On several recent ideaXme episodes, we have spent time on different topics pertaining to human health, disease, degeneration and aging, focused on a variety of therapeutic and preventative interventions being developed in the private sector of the economy, both here in the U.S. and more broadly globally.
We’ve also had representatives from various independent agencies of the United States Federal Government, the UK government (UKRI), and other foreign governmental agencies, join us to discuss many of the exciting public sector discoveries and development occurring, that possess massive trickle down benefits to the general public.
For example, over the last few months ideaXme has had several guests that have worked in different roles within NASA (U.S. National Aeronautics and Space Administration) talking about how research in space, can help improve the lives of us on Earth, where topics have included the bio-dynamics of sub-orbital flight training, astrobiology on the International Space Station (ISS), and even isolation chamber training for physical / psychological dynamics pertaining to future missions back to the Moon and Mars.
A study by Monash Biomedicine Discovery Institute (BDI) expands the understanding of the molecular pathways that control T cell function and survival and how it relates to declining T cell immunity in the elderly.
The findings, published in Nature Communications, led by Monash BDI’s Professor Nicole La Gruta and Dr. Kylie Quinn (formerly of Monash University BDI, now Vice-Chancellor’s Research Fellow at RMIT University), outline that the increased metabolism of T cells observed with advanced age was an indication that they were working harder merely to survive.
This contradicts previous knowledge, which suggested an increased metabolism was indicative of T cell function, and will have implications for the development of targeted interventions such as vaccines or immunotherapies to treat age-related immune dysfunction.
Undifferentiated human stem cells have been coaxed to develop into skin-like structures in vitro. When engrafted onto mice, the structures produce hair — highlighting the potential of the approach for regenerative therapies. Hair-follicle organoids that have a full complement of skin cells.
An underlying assumption of research on aging holds that dietary restriction (and drugs that mimic its effects) will slow aging to extend both lifespan and healthspan jointly. While eating a Spartan diet has been shown to robustly extend lifespan and delay age-related diseases in many species, a genome-wide analysis of 160 genetically distinct strains of the fruit fly D. melanogaster shows that lifespan and healthspan are not linked under dietary restriction. Results are published in Current Biology.
Though on average lifespan was extended and healthspan was increased, researchers from the Kapahi lab at the Buck Institute say the devil is in the details. In the study researchers measured nutrient-dependent changes in lifespan and tracked age-related changes in physical activity to measure healthspan. While 97 percent of strains showed some lifespan or healthspan extension in response to dietary restriction, only 50 percent of strains showed a significantly positive response to dietary restriction for both. Thirteen percent of the strains were more vigorous, yet died sooner with dietary restriction; 5 percent lived longer, but spent more time in poor health. The remaining 32 percent of the strains showed no benefits or detriments to lifespan or healthspan, or negative responses to both.
“Dietary restriction works, but may not be the panacea for those wanting to extend healthspan, delay age-related diseases, and extend lifespan,” said Pankaj Kapahi, Ph.D., Buck professor and senior author on the paper. “Our study is surprising and gives a glimpse into what’s likely going to happen in humans, because we’re all different and will likely respond differently to the effects of dietary restriction. Furthermore, our results question the idea that lifespan extension will always be accompanied by improvement of healthspan.”
