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Category: life extension – Page 361

Frozen humans brought back to life | 60 Minutes Australia

Though its a bit old, and sometimes innacurate or snarky in narration, it’s still the most detailed depiction of the cryonics process — the procedure itself on a real person, the person preserved before dying and her family as they decide to do this, deal with her death, and reflect on it after she’s preserved. It’s quite emotional and sometimes graphic, but well worth watching. Will it work? Maybe. But if you are NOT preserved there is NO chance at all. From your perspective it’d be like waking up right after dying in some distant future without feeling like any time passed at all.

That sounds a hell of a lot more appealing and likely than a bearded man on a fluffy cloud winking at me after I die.

Anita Riskin is one of hundreds of people who believe in cryonics — the process where doctors freeze human bodies. Preserve them, so that some time in the future they can be resuscitated — brought back to life. Now, as Anita Riskin sets out on her amazing journey, for the first time, you’ll see how it’s actually done — at times, quite graphically.

For forty years, 60 Minutes have been telling Australians the world’s greatest stories. Tales that changed history, our nation and our lives. Reporters Liz Hayes, Allison Langdon, Tara Brown, Charles Wooley, Liam Bartlett and Tom Steinfort look past the headlines because there is always a bigger picture. Sundays are for 60 Minutes.

WATCH more of 60 Minutes Australia: https://www.60minutes.com.au

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Bacterial metabolism of dietary soy may lower risk factor for dementia

The researchers found that while equol production did not appear to impact levels of amyloid-beta deposited within the brain, it was associated with reduced white matter lesion volumes. Sekikawa’s team also discovered that high levels of isoflavones—soy nutrients that are metabolized into equol—had no effect on levels of white matter lesions or amyloid-beta when equol wasn’t produced.

According to Sekikawa, the ability to produce equol from soy isoflavones may be the key to unlocking protective health benefits from a soy-rich diet, and his team has previously shown that equol production is associated with a lower risk of heart disease. As heart disease is strongly associated with cognitive decline and dementia, equol production could help protect the aging brain as well as the heart.

A metabolite produced following consumption of dietary soy may decrease a key risk factor for dementia—with the help of the right bacteria, according to a new discovery led by researchers at the University of Pittsburgh Graduate School of Public Health.

Their study, published today in the journal Alzheimer’s & Dementia: Translational Research & Clinical Interventions, reports that elderly Japanese men and women who produce equol—a metabolite of dietary soy created by certain types of gut bacteria—display lower levels of white matter lesions within the brain.

“White matter lesions are significant risk factors for cognitive decline, and all-cause mortality,” said lead author Akira Sekikawa, M.D., Ph.D., associate professor of epidemiology at Pitt Public Health. “We found 50% more white matter lesions in people who cannot produce equol compared to people who can produce it, which is a surprisingly huge effect.”

Reversing Skin Biological Age With Cutting-edge Longevity Science 🧬

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New vaccine could help halt Alzheimer’s progression, preclinical study finds

Our immune system’s capacity to mount a well-regulated defense against foreign substances, including toxins, weakens with age and makes vaccines less effective in people over age 65. At the same time, research has shown that immunotherapy targeting neurotoxic forms of the peptide amyloid beta (oligomeric Aβ) may halt the progression of Alzheimer’s disease, the most common age-related neurodegenerative disease.

A team led by Chuanhai Cao, Ph.D., of the University of South Florida Health (USF Health), has focused on overcoming, in those with impaired immunity, excess inflammation and other complications that interfere with development of a therapeutic Alzheimer’s vaccine.

Now, a by Dr. Cao and colleagues indicates that an antigen-presenting dendritic vaccine with a specific antibody response to oligomeric Aβ may be safer and offer clinical benefit in treating Alzheimer’s disease. The vaccine, called E22W42 DC, uses immune known as dendritic cells (DC) loaded with a modified Aβ peptide as the antigen.

Maverick Life: Who wants to live forever? (The immortal hydra already does)

“Who are we? What are we composed of? What is matter? What does matter? Is the body just a vessel with an expiration date?” asks American rapper GZA from Wu-Tang Clan, in Liquid Science, the show about science and imagination he hosts on Red Bull TV. In this episode, GZA is on a “quest to understand the human desire to live forever”.

Trying to find answers to such questions is nothing new. In an opinion piece for the Washington Post titled ‘‘Transhumanist’ eternal life? No thanks, I’d rather learn not to fear death’, Arthur C Brooks explains that, back in the fifth century before Christ, Greek historian Herodotus wrote about “a race of people in northern Africa who, according to local lore, never seemed to age”.

Eternal youth and immortality have always fascinated humanity, but we’ve not had much success finding them. Until now.

#51 Longevity Dialogues Part 1, The Long View. With Sergey Young, David Wood, and Jose Cordeiro

First in a series of Longevity Dialogues. Suggestions for future focus encouraged.

Host Mark Sackler conducts a lively discussion on issues involved with the anticipated implementation and implications of radical life extension. With XPrize innovation board member Sergey Young, and futurist authors David Wood and Jose Cordeiro.

Scientists home in on the mechanism that protects cells from premature aging

However, it was unclear how TERRA got to the tip of chromosomes and remained there. “The telomere makes up only a tiny bit of the total chromosomal DNA, so the question is ‘how does this RNA find its home?’” Lingner says. To address this question, postdoc Marianna Feretzaki and others in the teams of Joachim Lingner at EPFL and Lumir Krejci at Masaryk University set out to analyze the mechanism through which TERRA accumulates at telomeres, as well as the proteins involved in this process. The findings are published in * Nature*.

**Finding home**

By visualizing TERRA molecules under a microscope, the researchers found that a short stretch of the RNA is crucial to bring it to telomeres. Further experiments showed that once TERRA reaches the tip of chromosomes, several proteins regulate its association with telomeres. Among these proteins, one called RAD51 plays a particularly important role, Lingner says.

RAD51 is a well-known enzyme that is involved in the repair of broken DNA molecules. The protein also seems to help TERRA stick to telomeric DNA to form a so-called “RNA-DNA hybrid molecule”. Scientists thought this type of reaction, which leads to the formation of a three-stranded nucleic acid structure, mainly happened during DNA repair. The new study shows that it can also happen at chromosome ends when TERRA binds to telomeres. “This is paradigm-shifting,” Lingner says.

The researchers also found that short telomeres recruit TERRA much more efficiently than long telomeres. Although the mechanism behind this phenomenon is unclear, the researchers hypothesize that when telomeres get too short, either due to DNA damage or because the cell has divided too many times, they recruit TERRA molecules. This recruitment is mediated by RAD51, which also promotes the elongation and repair of telomeres. “TERRA and RAD51 help to prevent accidental loss or shortening of telomeres,” Lingner says. “That’s an important function.””

Molecules that accumulate at the tip of chromosomes are known to play a key role in preventing damage to our DNA. Now, researchers at EPFL have unraveled how these molecules home in on specific sections of chromosomes—a finding that could help to better understand the processes that regulate cell survival in aging and cancer.

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