After decades of research, here it is: the first promising evidence in humans, albeit imperfect and early, that a cocktail of three drugs is enough to reverse the epigenetic clock—a measure of someone’s biological age and health.
The results came as a surprise to even the research team, who originally designed the trial for something a little less dazzling: to look at human growth hormone’s effects on the thymus, the cradle of the body’s immune system that deteriorates with age.
“Maintained immune function is seen in centenarians,” and thymus function is linked to all-cause mortality, explained study author Dr. Gregory Fahy at Intervene Immune, based in Los Angeles, California. “So we were hoping to use a year of growth hormone to maintain thymus function in middle-aged men, right before the tissue’s functions take a nosedive,” he said.
For the December edition of the Journal Club hosted by Dr. Oliver Medvedik, we are joined by Dr. Matthew O’ Connor (Oki) formerly of SENS Research Foundation and now the head researcher at Underdog Pharma, a spin-off biotech company that is developing research conducted at SENS into a hopefully viable solution for heart disease.
Dr. O’Connor will be giving a short presentation covering the story of 7-Ketocholesterol, a harmful byproduct of oxidized cholesterol that Underdog believes is a suitable target for therapeautic intervention to prevent the formation of artery plaques, the basis of atherosclerosis. Then, we will review the new paper that his team has published and follow it up with discussion and questions.
A small study reveals that rapamycin, a drug with a long history as an immune suppressor, can improve tone and reduce wrinkles and sagging in human skin.
Jim Mellon, speaking at Master Investor’s Investing in the Age of Longevity 2019 event.
Master Investor is an investment media and events company that delivers independent, financial commentary and analysis to UK private investors and traders through events, magazines, news, blogs, podcasts and daily/weekly newsletters.
Nikola Danaylov at #DarkFutures: #NeoTechnocracy – The #Future is Worse than You Think.
This is the short closing speech I delivered at the 2019 Dark Futures meetup in Toronto. Not my finest speech but, since event organizer and futurist Nikolas Badminton kindly gave me a video of my keynote, I thought it may be good to share it publicly and get your critical feedback.
We will be returning in 2020 to host our third conference in New York City and brings together the leading experts in aging research and biotech business and investment. Building on the success of our 2018 and 2019 conferences we will continue to bring you the latest research, business, and investment talks from some of the top leaders in their fields.
We will be releasing more information about the conference in the coming months as we confirm speakers, venue, and dates. If you would like to stay informed about developments and ticket offers you may wish to sign up for the conference mailing list below.
Come early and enjoy snacks and conversation and stay afterward as we have a delicious 5-star dinner reception for Bill Faloon.
Before and after the service we will enjoy tasty food and interesting discussions on Age Reversal, Cryonics, Singularity and other topics of interest for all Immortalists.
As part of the LEAF Longevity Bookclub and to celebrate the launch of Dr. David Sinclair’s new book, Lifespan: Why We Age and Why We Don’t Have To, we hosted a special webinar on the 18th of September. The new book takes us on a journey through the biology of why we age and spotlights the exciting research being done in the lab today which could potentially change the way we treat the diseases of aging.
Dr. David Sinclair is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and in the top 50 most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than 35 awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. He lives in Boston and enjoys hiking and kayaking with his wife and three children.
Multiple prominent personalities and channels, including Joe Rogan, David Pakman, and Utah Public Radio, have interviewed him about his book, and we took the opportunity to allow the community to directly contact him. The webinar was an open event that offered up to 100 people a chance to join the video conference with Dr. Sinclair and to participate in the Q&A session following a reading of some of the exciting sections of the new book. We are delighted to announce that the webinar was an outstanding success, with over 90 people joining the call live to take part as well as many more watching via the livestream on our Facebook page. Five lucky attendees also won a copy of the book courtesy of Dr. Sinclair, and we would like to thank him for this kind offer as well as for taking the time to conduct this webinar with us.
