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Reverse Age

This is the FIRST part of the interview with Rodolfo Goya.


In this video Professor Goya talks about his role in the original experiment and the progress in his current study to reproduce the results with young blood plasma.

Professor Rodolfo Goya is Senior Scientist at The National Scientific and Technical Research Council in Argentina where he is a biochemist and researcher.

Dr. Goya has led a number of studies on cellular reprogramming and restoration of function in important organs, such as the thymus and the brain. He is also studying different aspects of cryopreservation.

He was one of the authors of the paper “Reversing age: dual species measurement of epigenetic age with a single clock” and is now working in his lab to reproduce and extend the results.

Gut microbiome implicated in healthy aging and longevity

The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism.

David Sinclair and Bracken Darrell take the stage on aging and life extension (Feb 2021)

Excellent hand and hand conversation between David Sinclair and Bracken Darrell. David is an expert in longevity and life extension, and Bracken is an experienced successful businessman, CEO of multinational Logitech.

The encounter took place on February 92021, during an online scientific symposium organized by the American Federation of Aging Research (AFAR).

The Symposium was launched under the following theme: “The Future is Now: Innovations in AI and Big Data for Healthspan and Longevity and it was a tribute to global geroscience visionary Sami Sagol.

If you’re familiar with the longevity field very likely you know who David Sinclair is, but for those who haven’t heard of Bracken Darrell before, he is an experienced and successful businessman, CEO of the Multinational Logitech.

Well known longevity leader Nir Barzilai acted as presenter and moderator of the conversation.

Buddhism in Huxley’s Evolution and Ethics

Julian Huxley was part of the intellectual dynasty started by TH Huxley, and is more influenced by Buddhist ideas than Judeo-Christian. “T. H. Huxley was a paleontologist with a medical background who gained great prominence in the nineteenth century as one of the foremost defenders of Darwin’s evolutionary theory. Victorians were often inclined to see him as “the living embodiment of science militant,”(8) for Huxley actually clashed with contemporary defenders of Biblical supernaturalism in the name of science.(9) A very late product of his intellectual career, Evolution and Ethics (1893) shows him in a mellowed, reflective mood. The radical disjunction between the ethical and the cosmic processes such as is frequently highlighted here hardly squares with “orthodox” Darwinism; in fact Irvine has called Huxley’s effort in this context a “somewhat puzzling manoeuvre” that is “full of talk about Indian mysticism and of protest about the cruelties of evolution.”(10) Yet his overall treatment of his theme is not a matter that need concern us now.(11) What must be noted, on the other hand, is that in the course of his professed endeavor to inquire into the origin and the basis of ethical values from an evolutionary standpoint, Huxley indeed undertook a brief survey of the leading philosophies that had helped to form mankind’s conceptions of such values. He emphasized in this connection that India had engendered a distinctive outlook on life, and some of the ideas central to that outlook (as, for example, karman) actually made a notable impression on him. But it is upon a particular religion of Indian origin, namely Buddhism, that he chose to dwell at length and, I think, in a way that merits close attention.” Buddhism is” system which knows no God in the Western sense; which denies a soul to man; which counts the belief in immortality a blunder and hope of it a sin; which refuses any efficacy to prayer and sacrifice; which bids men look to nothing but their own efforts for salvation; which in its original purity, knew nothing of vows of obedience, abhorred intolerance, and never sought the aid of the secular arm; yet spread over a considerable moiety of the Old World with marvellous rapidity, and is still, with whatever base admixure of foreign superstitions, the dominant creed of a large fraction of mankind.”


A note on a Victorian evaluation and its “comparativist dimension” By Vijitha Rajapakse Philosophy East and West Volume 35, no. 3 (July 1985)

©by the University of Hawaii Press

British perceptions of Buddhism tended to be surprisingly vague during the early part of the nineteenth century. Even so reputed an “authority” on India at the time as James Mill, for example, does not appear to have known anything definite on the subject; his famous The History of British India (1818) incorporates some lengthy commentaries on India’s cultural and intellectual achievements, but save for a bare reference, Buddhism, significantly, escaped his consideration. Evidently, James Mill, to all intents and purposes, viewed India as home to a single indigenous religion, Hinduism.(1) These perceptions, however, changed in due course, thanks to the advance of Oriental scholarship, especially Western research on Buddhist textual sources.

Aging industry blindspots | S Arrison, 100 Plus Capital, K Pfleger, AgingBiotech.info, M West, AgeX

57:03 “A tool that would be used for millenia.”


Foresight biotech & health extension group sponsored by 100 plus capital.

Accelerator applications are open now: https://foresight.org/biotech-health-extension-program.

Industry blindspots: Unincentivized work that could dramatically advance progress on aging.

SONIA ARRISON, 100 Plus Capital.

Dr. Ann Aerts, MD — Novartis Foundation — Transforming The Health Of Low-Income Populations Globally

Dr. Ann Aerts MD, Head of the Novartis Foundation and Member of the US National Academies of Medicine Commission on Healthy Longevity.


Dr. Ann Aerts, M.D. is Head of the Novartis Foundation, an organization committed to transforming the health of low-income populations, by leveraging the power of data, digital technology and artificial intelligence (AI) to re-imagine health and care around the world.

Dr. Aerts holds a Degree in Medicine, a Masters in Public Health from the University of Leuven, Belgium, and a Degree in Tropical Medicine from the Institute of Tropical Medicine in Antwerp, Belgium.

Dr. Aerts is passionate about improving population health through data, digital health and AI, chairs the Broadband Commission for Sustainable Development Working Group on Digital and AI in Health and is a member of the International Advisory Board of the Commonwealth Centre for Digital Health.

In 2018, Dr. Aerts served as a member of the US National Academies of Science Engineering and Medicine Committee on Improving the Quality of Health Care Globally and sits on the US National Academies of Medicine Commission on Healthy Longevity. Dr. Aerts has authored numerous publications on digital health, innovative approaches and multi-sector partnerships to address global health challenges.

How Scientists Reversed Aging, And What It Means For You

By blocking a receptor in macrophages, researchers were able to reverse aging in mice.


There are many suggested causes of old age. Telomere shortening, DNA damage, and depletion of stem cells are just a few of the proposed sources.

Recently, researchers found that a type of cell called a macrophage also plays a crucial role in aging. Macrophages are phagocytotic immune cells; they consume cells and other pathogens flagged by the immune system as dangerous. When macrophages need to consume a pathogen, their energy needs drastically go up.

Remember in biology when you were told that the mitochondria was the “powerhouse of the cell?” Cells produce energy through two main ways: glycolysis and oxidative phosphorylation. Both of these processes work inside the mitochondria by converting glucose into ATP, a molecule that acts cell’s “currency” on energy. Glycolysis converts glucose to ATP by degrading glucose into pyruvate. This reaction triggers the production of 2 ATP per molecule of glucose, which allows the cell can then use for other biological functions. Oxidative phosphorylation, on the other hand, is far more complicated, but also yields much more ATP. In a nutshell, it strips the electrons from hydrogen molecules so it can create an electrical gradient and produce up to 38 ATP per glucose molecule. Researchers found that as macrophages age, they tend to shut down these “metabolic pathways,” as they are called.

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