Archive for the ‘life extension’ category: Page 366
Apr 30, 2019
NMN Improves Cognitive Function in Aged Mice
Posted by Steve Hill in categories: biotech/medical, life extension, neuroscience
Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain.
The brain is a hungry organ
Healthy brain function relies on efficient cerebral blood flow (CBF) to wash away harmful waste products for disposal and supply the brain with an adequate supply of oxygen and sufficient nutrients.
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Apr 29, 2019
An Interview with Jose Cordeiro
Posted by Steve Hill in categories: bioengineering, biotech/medical, economics, finance, life extension, lifeboat, space
Jose Cordeiro is promoting the development of rejuvenation biotechnologies in Spain and the integration of Latin American immigrants into Spain’s aging society to maintain the country’s productivity. He was at the recent Undoing aging conference in Berlin and gave us an interview about his political goals.
At Undoing Aging 2019, jointly organized by SENS Research Foundation and Forever Healthy Foundation, there was a session focused on the ways to make healthy life extension and medical progress a greater part of the global agenda. Among the speakers there was Jose Cordeiro, the vice chair of Humanity Plus, director of The Millennium Project, fellow of the World Academy of Art and Science, and board member of the Lifeboat Foundation.
Apr 28, 2019
Combating Osteoarthritis With Stem Cells
Posted by Quinn Sena in categories: biotech/medical, life extension
An estimated 30 million Americans are affected by osteoarthritis according to the CDC, and it is predominantly a disease of older age affecting more than 1 in 10 people aged 60+; with the aging population this number is likely to continue to rise steadily.
When cartilage naturally cushioning joints breaks down, osteoarthritis of the knee occurs, without this buffer bones can come into contact with each other causing pain, stiffness, and loss of flexibility.
Medications and physical interventions can ease symptoms of osteoarthritis, but currently there is no sure as it is not possible to regrow cartilage, once progressed to end stages the only option is surgical replacement of the joint. Stem cells were recently used to ease osteoarthritis in a small scale preliminary trial with promising results that will pave the way for more larger studies.
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Apr 28, 2019
Human dental pulp stem cells: Applications in future regenerative medicine
Posted by Quinn Sena in categories: biotech/medical, life extension, neuroscience
Stem cells are pluripotent cells, having a property of differentiating into various types of cells of human body. Several studies have developed mesenchymal stem cells (MSCs) from various human tissues, peripheral blood and body fluids. These cells are then characterized by cellular and molecular markers to understand their specific phenotypes. Dental pulp stem cells (DPSCs) are having a MSCs phenotype and they are differentiated into neuron, cardiomyocytes, chondrocytes, osteoblasts, liver cells and β cells of islet of pancreas. Thus, DPSCs have shown great potentiality to use in regenerative medicine for treatment of various human diseases including dental related problems. These cells can also be developed into induced pluripotent stem cells by incorporation of pluripotency markers and use for regenerative therapies of various diseases. The DPSCs are derived from various dental tissues such as human exfoliated deciduous teeth, apical papilla, periodontal ligament and dental follicle tissue. This review will overview the information about isolation, cellular and molecular characterization and differentiation of DPSCs into various types of human cells and thus these cells have important applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as scientists working in the field of oral pathology and oral medicine.
Keywords: Human dental pulp stem cells, Mesenchymal stem cells, Dentin, Pluripotency, Stem cell therapy, Molecular markers.
Core tip: Human dental pulp stem cells (DPSCs) have shown a potentiality for the treatment of various human diseases including dental related problems. The review will overview the information about DPSCs, their isolation, cellular and molecular characterization, differentiation into various types of cells and their applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as the scientists working in the field of oral pathology, oral medicine and regenerative medicine.
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Apr 28, 2019
PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years? | Modern Wisdom Podcast #066
Posted by Jacob Anderson in categories: biotech/medical, genetics, life extension
David Sinclair is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul Glenn Centre for the Biological Mechanisms of Ageing.
Today we hear from a scientist at the cutting edge of longevity research as Professor Sinclair gives us a fascinating insight into the world of anti-ageing.
Apr 28, 2019
Persistence of Long-Term Memory in Vitrified and Revived Caenorhabditis elegans
Posted by Paul Battista in category: life extension
Rejuvenation ResearchVol. 18, No. 5Original ArticlesOpen Access Open Access license Persistence of Long-Term Memory in Vitrified and Revived Caenorhabditis elegans Natasha Vita-More and Daniel Barranco Natasha Vita-MoreAlcor Research Center (ARC), Alcor Life Extension Foundation, Scottsdale, Arizona. U…
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Apr 27, 2019
Coalition for Radical Life Extension
Posted by Paul Battista in category: life extension
What’s new at RAADfest 2019?? Besides RAADclinic, new topics will be discussed: Check it out and Register now: http://www.raadfest.com/
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Apr 26, 2019
New Gene Therapy Could Slow Aging in Humans
Posted by Quinn Sena in categories: biotech/medical, life extension, neuroscience
(Editor’s note: This podcast is from The Not Old – Better Show.)
As part of our Inside Science and Technology interview series, today’s show is an interview with Dr. Pradeep Reddy, a research scientist at the Salk Institute for Biological Studies.
As we all know in the Not Old Better Show audience, aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer’s disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy that is showing promise as a possible way to decelerate the aging process in humans. It uses CRISPR genome-editing technology.
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Apr 26, 2019
Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?
Posted by Paul Battista in categories: biotech/medical, life extension, robotics/AI
Aging is by far the dominant risk factor for the development of cardiovascular diseases, whose prevalence dramatically increases with increasing age reaching epidemic proportions. In the elderly, pathologic cellular and molecular changes in cardiac tissue homeostasis and response to injury result in progressive deteriorations in the structure and function of the heart. Although the phenotypes of cardiac aging have been the subject of intense study, the recent discovery that cardiac homeostasis during mammalian lifespan is maintained and regulated by regenerative events associated with endogenous cardiac stem cell (CSC) activation has produced a crucial reconsideration of the biology of the adult and aged mammalian myocardium. The classical notion of the adult heart as a static organ, in terms of cell turnover and renewal, has now been replaced by a dynamic model in which cardiac cells continuously die and are then replaced by CSC progeny differentiation. However, CSCs are not immortal. They undergo cellular senescence characterized by increased ROS production and oxidative stress and loss of telomere/telomerase integrity in response to a variety of physiological and pathological demands with aging. Nevertheless, the old myocardium preserves an endogenous functionally competent CSC cohort which appears to be resistant to the senescent phenotype occurring with aging. The latter envisions the phenomenon of CSC ageing as a result of a stochastic and therefore reversible cell autonomous process. However, CSC aging could be a programmed cell cycle-dependent process, which affects all or most of the endogenous CSC population. The latter would infer that the loss of CSC regenerative capacity with aging is an inevitable phenomenon that cannot be rescued by stimulating their growth, which would only speed their progressive exhaustion. The resolution of these two biological views will be crucial to design and develop effective CSC-based interventions to counteract cardiac aging not only improving health span of the elderly but also extending lifespan by delaying cardiovascular disease-related deaths.
Over the last decades, average life expectancy has significantly increased worldwide although several chronic diseases continue to grow, with aging as their main risk factor [1]. Aging is a natural and inevitable degenerative process of biological functions characterized by the progressive decline in tissue and organ homeostasis and function. Despite the significant improvements in diagnosis and treatment, the majority of individuals older than 65 years of age suffer from an elevated risk to develop cardiovascular diseases (CVDs), with a decline in the quality of life and in the ability to perform the normal activities of daily living [1]. Aging produces numerous changes in the human heart at structural, molecular, and functional levels [2].
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