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Category: life extension – Page 368

Can the Blue Zone Diet Lead to Life Extension?

TIL a preprint publication points to another commonality found in blue zones: their lack of birth records. Author Dr. Saul Justin Newman concludes, “the designated ‘blue zones’ of Sardinia, Okinawa, and Icaria corresponded to regions with low incomes, low literacy, high crime rate and short life expectancy relative to their national average. As such, relative poverty and short lifespan constitute unexpected predictors of centenarian and supercentenarian status, and support a primary role of fraud and error in generating remarkable human age records.”

Can the blue zone diet help with longevity? We investigate Dan Buettner’s claims about blue zones and the corresponding lifestyle.

High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?

Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science/article/pii/S002604952100038X

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466591/

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21:
https://pubmed.ncbi.nlm.nih.gov/18585098/

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice:
https://pubmed.ncbi.nlm.nih.gov/32877690/

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression:

Continue reading “High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?” | >

New Research Shows How to Boost Muscle Regeneration and Rebuild Tissue

In the myofiber-specific model, they found that adding the Yamanaka factors accelerated muscle regeneration in mice by reducing the levels of a protein called Wnt4 in the niche, which in turn activated the satellite cells.

Salk research reveals clues about molecular changes underlying muscle loss tied to aging.

One of the many effects of aging is loss of muscle mass, which contributes to disability in older people. To counter this loss, scientists at the Salk Institute are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are commonly used in stem-cell research.

In a study published on May 25, 2021, in Nature Communications, the investigators showed that using these compounds increased the regeneration of muscle cells in mice by activating the precursors of muscle cells, called myogenic progenitors. Although more work is needed before this approach can be applied in humans, the research provides insight into the underlying mechanisms related to muscle regeneration and growth and could one day help athletes as well as aging adults regenerate tissue more effectively.

Researchers develop better ways to culture living heart cells on the International Space Station

As part of preparing for an experiment aboard the International Space Station, researchers explored new ways to culture living heart cells for microgravity research. They found that cryopreservation, a process of storing cells at-80°C, makes it easier to transport these cells to the orbiting lab, providing more flexibility in launch and operations schedules. The process could benefit other biological research in space and on Earth.

The investigation, MVP Cell-03, cultured heart precursor on the station to study how microgravity affects the number of cells produced and how many of them survive. These precursor cells have potential for use in disease modeling, drug development, and , such as using cultured to replenish those damaged or lost due to cardiac disease.

Previous studies suggest that culturing such cells in simulated microgravity increases the efficiency of their production. But using live cell cultures in space presents some unique challenges. The MVP Cell-03 experiment, for example, must be conducted within a specific timeframe, when the cells are at just the right stage. Flight changes and crew availability could lead to delays that affect the research.

Young Blood Plasma Extending Rats Max Lifespan | Professor Rodolfo Goya’s Experiment Update

Things to note: Treating the rats until they die. They are at 31 months and the longest they have lived without treatments is 38 months. Also, a small number of people have done this and though ailments like arthritis go away they still look elderly.

We recently had an update from Professor Rodolfo Goya who is conducting a follow up experiment from the one that Dr. Katcher first did in India, showing a rejuvenation in old rats. This video goes through the update that we had and provides a short introduction to the background.

Nicolas Chernavsky recently also did an interview with Didier Coeurnelle which discussed the update, which you can find here : https://youtu.be/GMNXjvXV268

Our earlier videos on the previous experiment and interview with Dr. Katcher are in this playlist https://www.youtube.com/playlist?list=PLkfzM7KJv6vaIQZ_n3WS6FHTpBtfS2lzw.

Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation.

Continue reading “Young Blood Plasma Extending Rats Max Lifespan | Professor Rodolfo Goya’s Experiment Update” | >

Diet and Lifestyle Change Reverses Aging

It would be nice if they listed their diet.

Summary: Simple dietary changes and adopting lifestyle alterations, including improved sleep schedules, taking probiotics, and exercising, can reduce signs of biological aging by three years in just eight weeks, a new study reports.

Source: Impact Journals

A groundbreaking clinical trial shows we can reduce biological age (as measured by the Horvath 2013 DNAmAge clock) by more than three years in only eight weeks with diet and lifestyle through balancing DNA methylation.

A first-of-its-kind, peer-reviewed study provides scientific evidence that lifestyle and diet changes can deliver immediate and rapid reduction of our biological age. Since aging is the primary driver of chronic disease, this reduction has the power to help us live better, longer.

Greg Fahy, Intervene Immune | Thymus Rejuvenation Progress Update

More on thymus regeneration. Unless I understood wrong one patient’s epigenetic clock went from his mid 50’s to early 40’s.

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.

2021 program & apply to join: https://foresight.org/biotech-health-extension-program/

Greg Fahy, Intervene Immune.
Thymus Rejuvenation Progress Update.

- Designed and led the TRIIM trial; Published the first report of thymus regeneration in a normal human; Granted patents on methods for and applications of human thymus regeneration.

Continue reading “Greg Fahy, Intervene Immune | Thymus Rejuvenation Progress Update” | >

Society of Immortals

When immortality is available to the masses and not just the rich.

This is when immortality is granted on a large scale: to an entire civilization, or a village. Species that are naturally immortal such as elves fall under this as well. This can sidestep some of the problems inherent to immortality because when everyone is immortal then no one is alone and the general culture and mindset is that immortality is ‘normal’ and death is not.

Their source of immortality may be a large or mass-produced Immortality Inducer. If their immortality involves Immortality Immorality it may overlap with Town with a Dark Secret. There’s also the question of what type of Immortality the civilization has; a society whose members can respawn quickly after death will be different from one whose members never die from old age and both will be different from one whose members never die, period. Regardless, Immortal Procreation Clause is likely to be in effect and little attention will be paid to the traditional gender roles.

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