Lifeboat Foundation

Christian Schafmeister, Ph.D., Professor at Temple University in Philadelphia says: “We are developing “therapeutic catalysts” — small, robust, non-immunogentic catalysts that will permeate the tight spaces within tissues and fix things. Our specific targets include reversing the unwanted cross-links that develop in the extracellular matrix with aging.”

Enzymes, while possessing exquisite substrate-specificity, are limited by their molecular size in their ability to gain access to their substrate when it is embedded within dense material. We have always known that this may be a problem for our approach to restoring the elasticity of aged tissues. Christian’s fascinating work offers the potential to solve this issue with molecules that have the same catalytic function as enzymes but are much smaller and can therefore reach these embedded substrates.

Had a very frank discussion with Greg Mustreader about transhumanism, learned helplessness of society in the face of aging and death, insufficient sense of urgency among researchers of aging, epigenetic rejuvenation, cryonics, and so on. No filter! 😁.

My blog on Medium: https://medium.com/@mustreader

Continue reading “Yuri Deigin on epigenetic rejuvenation, longevity research and transhumanists in politics” »

Turquoise killifish is able to suspend its development for longer than its average lifespan.

Researchers have discovered that the powerhouses of our cells, the mitochondria, also play a role in triggering cells to enter senescence, a dormant state in which cells cease to divide and begin to shut down, ready to die.

Mitochondria trigger cytoplasmic chromatin and inflammation

The new study shows that the mitochondria in each cell communicate with its nucleus, causing it to shut down and enter a senescent state [1]. Dr. Peter Adams, one of the study’s researchers, has spent over a decade investigating how chromatin clusters, a mixture of DNA and proteins typically encountered in the cell nucleus, actually leak out of the nucleus and into the cytoplasm in senescent cells. This leaking then triggers a cascade of inflammatory signals, which are linked to the onset of various age-related diseases.

King’s College in London, UK has been awarded a grant to investigate the role of senescent cells, which accumulate as we age, in the context of the heart and how using a therapy to remove them influences its ability to recover from injury.

What are senescent cells?

As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby healthy cells to enter the same senescent state. Their presence causes many problems: they reduce tissue repair, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related diseases.

In my previous post “Cryonics for uploaders: WTF is consciousness?” I didn’t elaborate on the spiritual implications of emerging theories of consciousness and reality. Here’s a unified theory of consciousness, physics, Deity, reincarnation, afterlife, eschatology, and theo/technological resurrection wink

Do you want to stop ageing? Do you want to live forever? Can science help you cheat death? In this pioneering documentary, Professor Rose Anne Kenny takes us through the science and the consequences of living longer lives.

Imagine for a moment that old age became a thing of the past. Today, for better or for worse, it would appear that eternal life may soon be a reality. Some scientists are forecasting that the only way many humans will die is if they are shot or run over by a bus.

Continue reading “When Living 200 Year Becomes Normal — The End of Ageing (Medical Science Documentary) | Only Human” »

By definition, posthumanism (I choose to call it ‘cyberhumanism’) is to replace transhumanism at the center stage circa 2035. By then, mind uploading could become a reality with gradual neuronal replacement, rapid advancements in Strong AI, massively parallel computing, and nanotechnology allowing us to directly connect our brains to the Cloud-based infrastructure of the Global Brain. Via interaction with our AI assistants, the GB will know us better than we know ourselves in all respects, so mind-transfer, or rather “mind migration,” for billions of enhanced humans would be seamless, sometime by mid-century.

I hear this mantra over and over again — we don’t know what consciousness is. Clearly, there’s no consensus here but in the context of topic discussed, I would summarize my views, as follows: Consciousness is non-local, quantum computational by nature. There’s only one Universal Consciousness. We individualize our conscious awareness through the filter of our nervous system, our “local” mind, our very inner subjectivity, but consciousness itself, the self in a big sense, our “core” self is universal, and knowing it through experience has been called enlightenment, illumination, awakening, or transcendence, through the ages.

Any container with a sufficiently integrated network of information patterns, with a certain optimal complexity, especially complex dynamical systems with biological or artificial brains (say, the coming AGIs) could be filled with consciousness at large in order to host an individual “reality cell,” “unit,” or a “node” of consciousness. This kind of individuated unit of consciousness is always endowed with free will within the constraints of the applicable set of rules (“physical laws”), influenced by the larger consciousness system dynamics. Isn’t too naïve to presume that Universal Consciousness would instantiate phenomenality only in the form of “bio”-logical avatars?

A BONKERS Russian billionaire claims he’ll make you immortal by 2045.

Internet businessman Dmitry Itskov, 38, is bankrolling a far-fetched plan to uploaded people’s personalities to artificial brains.

These “brains” can then be jammed into robots or holograms, allowing us to live on forever as artificial versions of ourselves, Dmitry claims.