Researchers and entrepreneurs are starting to ponder how AI could create versions of people after their deaths—not only as static replicas but as evolving digital entities that may steer companies or influence world events.
Experts are exploring ways artificial intelligence might confer a kind of digital immortality, preserving the personalities of the departed in virtual form and then allowing them to evolve.
The Gist: They think they can start wider human trials soon which would last 2 years then have a product in 3 to 4 years.
In this video, Drs Irina and Mike Conboy talk how TPE, therapeutic plasma exchange is already available as an FDA approved procedure and the plans to extend the usage to include more age related diseases. We also discuss the company that they have formed IMU
Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.
Did you know that life extension is impossible? I didn’t until the keen minds over at the Guardian informed me as such. Fortunately before I decided to give up my career in regenerative medicine I decided to look into exactly how the Guardian came to such a revelation. What I discovered was so earth shattering that it rocked my very understanding of the world, and made me question everything I thought I knew. That realisation was that, despite their consistent insistence to the contrary, the media lies, a lot.
Ok maybe this was not as shocking as I made it out to be, in fact it’s pretty widely known by now that the media is generally no stranger to the odd lie here and there. If you are not familiar with the story allow me to give you a recap. A recent study was conducted in order to find out if human lifespans have actually increased due to advanced in medicine. To do this, scientists used statistical models to remove non-age related causes of death from historical records (such as murder, death in child birth, plague etc) in order to determine what the uninterrupted human lifespan is, and if it has increased over time. What was found is that our medical science is yet to fundamentally extend human lifespan. This comes as no surprise to anyone in the field of longevity research as we know full well that none of our current medical treatments address causes of ageing. What this study does not conclude however is that life extension is impossible.
US$8.5 Billion In Funding — 150+ Projects
Dr. Maria Millan, MD, is the President and CEO of the California Institute for Regenerative Medicine (CIRM — https://www.cirm.ca.gov/), an organization that was created in 2004 when voters initially approved a state Proposition which allocated US$3 billion to fund this fascinating area of medicine, and which recently received an additional US$5.5 billion in renewed funding.
Dr. Millan is a physician-scientist who has devoted her career to treating and developing innovative solutions for children and adults with debilitating and life-threatening conditions.
Posted in biotech/medical, life extension
Not just the results, but the vector used. I’ll post the paper below.
In this video we cover an experiment where gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery. Please note that this a preprint which is not peer-reviewed yet.
Papers referred to in this newsletter.
Antiaging gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery.
Liz Parish of Bioviva has treated herself with all of these antiaging gene therapies.
If humans experienced the same antiaging effect as the mice then humans would live to a median age of 100 with these treatments.
Posted in cryonics, life extension
Sun, Sep 12 at 12 PM PDT.
This is an invitation to the Annual General Meeting of the Cryonics Institute & the Immortalist Society.
The Cryonics Institute, Annual General Meeting (AGM) will be held at 3:00pm to 6:30pm on Sunday, September 12th, 2021 at the Infinity Hall 16650 E. 14 Mile Rd, Fraser, MI 48026 (USA) for more information visit www.infinityhallsidebar.com or call 586−879−6157. Tours at the CI facility will be from 1:00pm to 2:30pm 24355 Sorrentino Court, Clinton Township, (Michigan) 48035 (USA).
The AGM of the Immortalist Society will be held after the CI AGM on the same day at the same location. The two meetings generally last most of the afternoon. A buffet dinner & social follow. The CI facility will be open to guests and visitors two hours before the meeting begins.
Not sure how interesting this will be to people who know a lot on aging/longevity research.
A team of researchers at Brigham and Women’s Hospital and Harvard Medical School have found evidence of mouse and human germline cells resetting their biological age. In their paper published in the journal Science Advances, the group describes their study of the aging process in germline cells and what they found by doing so.
As animals grow older, all of the cells in their body replicate themselves repeatedly. As the process continues, errors in replicating and other external factors (such as exposure to pollutants) lead to gradual decay in cell quality, which is all part of the natural aging process. In this new effort, the researchers have found evidence showing that germline cells have a mechanism for resetting this process, allowing offspring to reset their aging clocks.
Germline cells pass on genetic material from parent to offspring during the reproductive process. For many years, scientists have wondered why these cells do not inherit the age of their parents. And for many years, they assumed that the cells were ageless, but recent work has shown that they do, in fact, age. So that raised the question of how offspring are able to begin their lives with fresh cells.
I was at HudsonAlpha’s spinoff clinic for rare diseases, the Smith Family Clinic for Genomic Medicine. Most people don’t know this, but the second largest biomedical research campus in the USA and the fourth in the entire world is in Alabama. Long-read genome sequencing is essential for aging research because it is able to detect methylation and acetylation very conveniently, as well as major structural changes to the genome that are associated with both rare disease AND aging. This is an explanation of how long-read sequencing is able to fill in sequence gaps caused by Illumina short-read technology.
In 2020, Chromosome X and 8 were finished end-to-end with long-read sequencing, for the first time. And now in 2021, a complete gapless human genome is on the horizon. The Human Genome Project may finally, truly become complete.
February 3, 2021 (Huntsville, Ala.) – Researchers at the HudsonAlpha Institute for Biotechnology used a new, cutting-edge genomic sequencing technology to help physicians make diagnoses for two pediatric patients who had been on long diagnostic journeys.
Limitations of traditional sequencing in neurodevelopmental disease diagnosis
Short of ceasing your grilling activity, there’s no way to completely avoid AGEs, PAH, and HCA when enjoying a summer barbecue. That said, there’s plenty you can do to reduce your carcinogen risk while enjoying smokey flavors over the summer.
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Hickory and oak wood and charcoal are the scents of summer. I associate that campfire smell with fireworks, screaming with neighborhood kids while jumping through a lawn sprinkler, and Dad at the grill with a Blue Moon in hand. Barbeque is a wonderful pastime. So help me, nothing will pry it out of my red-blooded American hands, especially not on the Fourth of July.
And that’s a bit of a problem, as I’m also pursuing human life extension. I’m not talking about the potential fire hazard that grilling is (or the associated $37 million of property damage they cause every year). The trouble is carcinogens. There are a lot of well-established barbecue health risks.
