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Archive for the ‘life extension’ category: Page 257

Mar 2, 2020

Cyborgs, Robots, And Biohackers: The First-Ever Survey of Transhumanism

Posted by in categories: biotech/medical, cyborgs, life extension, neuroscience, robotics/AI, transhumanism, wearables

the photo series by vintner and fletcher illustrates three gradual stages of transhumanism from ‘testing ground’, ‘patient zero’ to ‘humanity 2.0’. at the lowest tier, ‘testing ground’ looks into individuals who have created wearable technology to expand their human abilities, improving everything from concentration to mental health.‘patient zero’ studies those who have taken permanent action to become half human and half robot. in the final chapter, ‘humanity 2.0’, the transhumanist subjects focus on life extension and immortality.

Mar 1, 2020

Can Destroying Senescent Cells Treat Age-Related Disease?

Posted by in categories: biotech/medical, life extension

I think so.


A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.

Mar 1, 2020

The theory of longevity of Aubrey de Gray — how in the coming years we will defeat aging

Posted by in category: life extension

Yet another talk from Aubrey.

Mar 1, 2020

First human to live 1,000 years may already be alive says scientist fighting to end ageing

Posted by in category: life extension

Are you the one?


THE FIRST human to live for over 1,000 years is probably already alive according to Dr Aubrey de Grey, a British scientist who is working to stop human ageing.

Feb 29, 2020

114 Year-Old Cells Converted to Pluripotent Stem Cells

Posted by in categories: biotech/medical, life extension

I think I can speak for us older folks on this…YAY!


AgeX converts the cells of deceased 114-year-old into young pluripotent stem cells; evidence of telomere aging reversal in a supercentenarian’s cells.

Feb 29, 2020

Caloric restriction study suggests aging could be “reversible” in the future

Posted by in categories: futurism, life extension

Rats on a unique diet were protected against cellular aging.

Feb 28, 2020

Dr. Frank Sabatino presents “The Plant Based Fountain of Youth, the Science of Healthy Aging”

Posted by in categories: education, life extension, science

Dr. Frank Sabatino is currently the Health Director of the Balance for Life Health Retreat, a lifestyle education center specializing in plant based nutrition, health rejuvenation, stress management, therapeutic fasting and detoxification.

“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov

Continue reading “Dr. Frank Sabatino presents ‘The Plant Based Fountain of Youth, the Science of Healthy Aging’” »

Feb 28, 2020

Guardian Angel‘ Protein Molecule Inside Cells is Identified

Posted by in categories: biotech/medical, genetics, life extension

O.o um what?


Over the past few years biologists have developed several lines of evidence showing that one particular protein molecule inside cells plays an extraordinary variety of life-protecting roles, so much so that the molecule has been dubbed a “guardian angel.” The findings are leading to greater knowledge of how life works and to a deeper understanding of the root causes of cancer.

So pervasive is the molecule’s role that scientists in four areas of biology were on the trail of it, each field unaware, until recently, of the protein’s importance in the others.

Continue reading “Guardian Angel‘ Protein Molecule Inside Cells is Identified” »

Feb 28, 2020

Scientists show how caloric restriction prevents negative effects of aging in cells

Posted by in categories: biotech/medical, life extension, neuroscience

If you want to reduce levels of inflammation throughout your body, delay the onset of age-related diseases, and live longer—eat less food. That’s the conclusion of a new study by scientists from the US and China that provides the most detailed report to date of the cellular effects of a calorie-restricted diet in rats. While the benefits of caloric restriction have long been known, the new results show how this restriction can protect against aging in cellular pathways, as detailed in Cell on February 27, 2020.

“We already knew that calorie restriction increases life span, but now we’ve shown all the changes that occur at a single-cell level to cause that,” says Juan Carlos Izpisua Belmonte, a senior author of the new paper, professor in Salk’s Gene Expression Laboratory and holder of the Roger Guillemin Chair. “This gives us targets that we may eventually be able to act on with drugs to treat aging in humans.”

Aging is the highest risk factor for many human diseases, including cancer, dementia, diabetes and metabolic syndrome. Caloric restriction has been shown in animal models to be one of the most effective interventions against these . And although researchers know that undergo many changes as an organism ages, they have not known how caloric restriction might influence these changes.

Feb 27, 2020

Treating Systemic Klotho Deficiency

Posted by in categories: biotech/medical, life extension

The serendipitous disruption of the klotho gene promoter in 1997 by a cardiologist in Japan begot a phenotype of early multiorgan failure mimicking premature aging [1]. The gene was aptly named after the Greek Goddess who spins the threads of life. In 2005, the same investigator did the opposite experiment and showed that transgenic overexpression of klotho in mice extends life, placing Klotho once again in the spotlight and generated volumes of antiaging research [2]. Several findings that followed changed the landscape. Klotho is a single-pass transmembrane protein, primarily expressed in the kidney, but its extracellular domain is secreted into circulation as a soluble protein after being cleaved by proteases [3]; thus, the kidney supplies the body with soluble Klotho [3]. In multiple preclinical studies with diverse models, both acute and chronic kidney diseases are states of renal and systemic klotho deficiency [3], including human CKD. The relationship between Klotho and kidney disease is more than just a biomarker because restoration of Klotho ameliorated renal dysfunction and extrarenal complications in both acute [4] and chronic settings bringing Klotho supplementation into the therapeutic realm. However, how should Klotho be given?

In rodents, several methods have been used successfully to raise systemic Klotho levels (Fig. 1). The transgenic insertion of klotho into the genome of a mouse was the first attempt [2]. While this has been enormously useful as proof-of-concept in experimental animals, this technique is not applicable to patients currently. Recombinant Klotho protein was used successfully in the laboratory in both acute and chronic [5] settings that prevented AKI, accelerated AKI recovery, presented and retarded AKI-to-CKD transition, and ameliorated extrarenal complications [4]. Recombinant Klotho protein administration is a method where translation to human therapeutics is much more practical and proximal.