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Category: life extension – Page 254

Cellular Reprogramming Upcoming Human Trials | Prof Vittorio Sebastiano Interview Series 2 Ep4

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In this video Professor Sebastiano discusses the three most advanced interventions that Turn Bio is working on, for skin, immunology and muscles and when they will be available for human trial.

Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.

Turn Bio website.
https://www.turn.bio/
Professor Sebastiano’s lab at Stanford.
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html.
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
https://pubmed.ncbi.nlm.nih.gov/32210226/

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Quantifying Biological Age: Blood Test #7 in 2022

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Robust Mouse Rejuvenation project details announced

The newly-created Longevity Escape Velocity Foundation (LEV) has released details of the first study in its flagship research programme: Robust Mouse Rejuvenation – Study 1.

Longevity. Technology: A highlight of Longevity Summit Dublin 2022 was Dr Aubrey de Grey’s announcement of his new foundation; LEV Foundation exists to proactively identify and address the most challenging obstacles on the path to the widespread availability of genuinely effective treatments to prevent and reverse human age-related disease, and to that end, its flagship research programme is a sequence of large mouse lifespan studies.

Mouse models are significant in aging research for several reasons. Mice and humans share many genetic and physiological similarities, including similar aging-related pathways, and this makes mice a useful model for studying the molecular and cellular processes underlying aging in humans.

155 Newly Identified Genes Reveal Humans Are Continuously Evolving

We never stopped evolving.

Are humans still evolving? This question is a mystery for many, as about seven million years have passed since humans left the chimpanzee lineage. The factors that forced us to adapt, evolve, and survive harsh environments in the past are no longer relevant.

So does that mean we have stopped evolving?

CIPhotos/iStock.

Today, humans have much longer lifespans and advanced healthcare facilities at their disposal. We live in a comfortable and protected environment almost all the time. The external factors (also known as selection pressures) that previously kept us in continuous survival mode don’t affect us anymore.

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COPL Remembrance of The Resurrectables 2022

We celebrate the Remembrance of the Resurrectables each year. A ceremony for remembering all of the patients that are in Cryonic Suspension awaiting an eventual return to a full healthy life.

Go To https://youtu.be/NgdwYAWCy88 for part 1 of our service: Dr. Richard Olree “Minerals for Telomeres” and “Age Reversal Update” with Bill Faloon.

“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov.

We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.

Working to Save Lives with Age Reversal Education.

Scientists found previously unknown genes that show humans are still evolving

But even junk has hidden treasures. Studies found variations in these unsequenced regions were intricately involved in human health, from aging to conditions like cancer and developmental disorders like autism. In 2022, a landmark study finally resolved the genomic unknown, completely sequencing the remaining eight percent of undeciphered DNA remaining.

Now, scientists are discovering that some genetic sequences encode proteins that lack any obvious ancestors, what geneticists call orphan genes. Some of these orphan genes, the researchers surmise, arose spontaneously as we evolved, unlike others that we inherited from our primate ancestors. In a paper published Tuesday in the journal Cell Reports, researchers in Ireland and Greece found around 155 of these smaller versions of DNA sequences called open reading frames (or ORF) make microproteins potentially important to a healthy cell’s growth or connected to an assortment of ailments like muscular dystrophy and retinitis pigmentosa, a rare genetic disease affecting the eyes.

“This is, I think, the first study looking at the specific evolutionary origins of these small ORFs and their microproteins,” Nikolaos Vakirlis, a scientist at the Biomedical Sciences Research Center “Alexander Fleming” in Greece and first author of the paper, tells Inverse. It’s an origin, he says, that’s been mired in much question and mystery.

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