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Category: life extension – Page 251

Very technical and it’s from the usually secretive Calico.

Jacob Kimmel of Calico Labs discusses how cells can be reprogrammed to restore youthful expression through transient suppression of cell identity at Lifespan.io’s 2021 EARD conference.

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Jacob Kimmel is a Principal Investigator at Calico Life Sciences leading a research program focused on repurposing developmental programs to address aging and age-related disease. His recent work has revealed the influence of cell identity on aging trajectories, discovered mechanisms of age-related impairment in muscle stem cells and developed machine learning methods for the analysis of single-cell genomics data. Prior to Calico, Jacob completed Ph.D. training with Wallace Marshall and Andrew Brack at the University of California San Francisco where he developed methods to measure cell state transitions with timelapse microscopy techniques.

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging.

Continue reading “Reversing Cell Age, Suppressing Cell Identity, Can Ontogeny Be Reversed? — Jacob Kimmel Lifespan.IO” | >

As we age, our muscles gradually become smaller, weaker and less able to heal after injury. In a new study, UPMC and University of Pittsburgh researchers pinpoint an important mediator of youthfulness in mouse muscle, a discovery that could advance muscle regeneration therapies for older people.

Published today in Nature Aging, the study demonstrates that circulating shuttles called , or EVs, deliver for the longevity protein known as Klotho to cells. Loss of muscle function and impaired muscle repair in old may be driven by aged EVs, which carry fewer copies of these instructions than those in .

The findings are an important advance in understanding why the capacity for muscles to regenerate dwindles with age.

Read more | >

Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

The team, led by Professor Luc Mongeau and Assistant Professor Jianyu Li, developed a new injectable hydrogel for wound repair. The hydrogel is a type of biomaterial that provides room for cells to live and grow. Once injected into the body, the biomaterial forms a stable, porous structure allowing live cells to grow or pass through to repair the injured organs.

Read more | >

Due to last years success, I am back with an updated list of my 5 most promising anti-aging compounds.

There are more than 200 different geroprotective compounds. Some of these are already available as supplements, some are in clinical trials and some have FDA approval. Which are my top 5 that I think i most promising in terms of their anti-aging effects (so focusing more on healthspan than lifespan). And note the use of “promising” — there is still much work to be done to better investigate the long-term safety, dose and timings of different supplements which you should always bear in mind.

Anyway, I made this video more for a bit of fun and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it! And disclaimer — this is not recommendation or health advise — i am not a medical doctor!!

Do my top 5 match yours?

Find me on Twitter — https://twitter.com/EleanorSheekey.

I have Patreon — https://www.patreon.com/TheSheekeyScienceShow.

Continue reading “5 Most Promising Anti-Aging Compounds (Updated 2022)” | >

Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

Read more | >

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Papers referenced int the video:
Joint distribution of lipoprotein cholesterol classes. The Framingham study.
https://pubmed.ncbi.nlm.nih.gov/6573877/

Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS)
https://pubmed.ncbi.nlm.nih.gov/20223457/

Red blood cell distribution width and cardiovascular diseases.
https://pubmed.ncbi.nlm.nih.gov/26623117/

Red blood cell distribution width is significantly associated with aging and gender.
https://pubmed.ncbi.nlm.nih.gov/24897405/

Red cell distribution width associations with clinical outcomes: A population-based cohort study.

Continue reading “How Many Calories Are Optimal For Health?” | >

Engie and Macquarie to build 150MW one hour battery at site of shuttered Hazelwood coal generator.

French energy giant Engie and Macquarie’s Green Investment Group are to jointly fund the construction of a 150MW/150MWh big battery at the site of the now closed Hazelwood brown coal generator.

The announcement, which comes four years after Engie closed what was Australia’s dirtiest power station, continues the trend of using the sites of closed or ageing coal and gas plants to build battery storage to support the switch to 100 per cent renewables.

Construction has already begun on the Hazelwood Battery, which will be built and maintained over a 20-year period by US-based Fluence, using – for the first time in Australia – its sixth-generation Gridstack product and its AI-enabled bidding system.

Read more | >