One of the most terrifying things about Dune is the fact that it rather accurately predicted what the next front of warfare will look like: genetic warfare. In twenty twenty five, gene manipulation is the biggest threat in the theatre of war, because one gene-altering weapon can render an enemy force infertile at best, and terribly mutated at worst. But that’s not something that happens to the products of breeding programmes in the Dune-verse, at least on a physical level. In this video, we will take a look at every breeding programme in Frank Herbert’s creation, and talk about their horrifying histories in detail.
Developmental time (or time to maturity) strongly correlates with an animal’s maximum lifespan, with late-maturing individuals often living longer. However, the genetic mechanisms underlying this phenomenon remain largely unknown. This may be because most previously identified longevity genes regulate growth rate rather than developmental time. To address this gap, we genetically manipulated prothoracicotropic hormone (PTTH), the primary regulator of developmental timing in Drosophila, to explore the genetic link between developmental time and longevity. Loss of PTTH delays developmental timing without altering the growth rate. Intriguingly, PTTH mutants exhibit extended lifespan despite their larger body size. This lifespan extension depends on ecdysone signaling, as feeding 20-hydroxyecdysone to PTTH mutants reverses the effect. Mechanistically, loss of PTTH blunts age-dependent chronic inflammation, specifically in fly hepatocytes (oenocytes). Developmental transcriptomics reveal that NF-κB signaling activates during larva-to-adult transition, with PTTH inducing this signaling via ecdysone. Notably, time-restricted and oenocyte-specific silencing of Relish (an NF-κB homolog) at early 3rd instar larval stages significantly prolongs adult lifespan while delaying pupariation. Our study establishes an aging model that uncouples developmental time from growth rate, highlighting NF-κB signaling as a key developmental program in linking developmental time to adult lifespan.
ITrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at https://impacttheory.co/iTrustCapitalMay.
Shopify: Sign up for your one-dollar-per-month trial period at https://impacttheory.co/ShopifyApr.
On this mind-bending episode of Impact Theory, Tom Bilyeu sits down with Ben Lamm, the visionary entrepreneur behind Colossal Biosciences, to explore a world that sounds straight out of science fiction—yet is rapidly becoming our reality. Together, they pull back the curtain on the groundbreaking technology making de-extinction not only possible, but increasingly practical, from resurrecting woolly mammoths and dire wolves to saving endangered species and unraveling the secrets of longevity.
Ben explains how CRISPR gene editing has unlocked the power to make precise DNA changes—editing multiple genes simultaneously, synthesizing entirely new genetic blocks, and pushing the limits of what’s possible in biology and conservation. The conversation dives deep into the technical hurdles, ethical questions, and the unexpected magic of re-engineering life itself, whether it’s creating hairier, “woolly” mice or tackling the colossal challenge of artificial wombs and universal eggs.
But this episode goes way beyond Jurassic Park fantasies. Tom and Ben debate the future of human health, gene selection through IVF, the specter of eugenics, global competition in biotechnology, and how AI will soon supercharge the pace of biological engineering. They even touch on revolutionary solutions to our plastic crisis and what it means to inspire the next generation of scientists.
Get ready to have your mind expanded. This is not just a podcast about bringing back extinct creatures—it’s a deep dive into the next frontiers of life on Earth, the technologies changing everything, and the choices we’ll face as architects of our own biology. Let’s get legendary.
00:00 Meet Ben Lamm.
A multi-institutional collaboration of synthetic biology research centers in China has developed a genetically engineered strain of Vibrio natriegens capable of bioremediating complex organic pollutants, including biphenyl, phenol, naphthalene, dibenzofuran, and toluene, in saline wastewater and soils.
Complex organic pollutants are prevalent in industrial wastewater generated by petroleum refining and chlor-alkali processing. Due to their chemical stability and resistance to natural degradation, these compounds persist in marine and saline environments, posing ecological risks and potential threats to public health.
Microbial bioremediation methods typically use consortia of wild-type bacterial strains, yet these organisms demonstrate limited capacity to degrade complex pollutant mixtures. Elevated salinity levels further inhibit bacterial activity, diminishing bioremediation efficacy in industrial and marine wastewater. Developing bacterial strains capable of degrading pollutants while tolerating saline conditions remains a critical challenge.
The human brain is known to contain a wide range of cell types, which have different roles and functions. The processes via which cells in the brain, particularly its outermost layer (i.e., the cerebral cortex), gradually become specialized and take on specific roles have been the focus of many past neuroscience studies.
Researchers at the University of California Los Angeles (UCLA) analyzed different datasets collected using single-cell transcriptomics, a technique to study gene expression in individual cells, to map the emergence of different cell types during the brain’s development.
Their findings, published in Nature Neuroscience, unveil gene “programs” that drive the specialization of cells in the human cerebral cortex.
Kilili, H., Padilla-Morales, B., Castillo-Morales, A. et al. Sci Rep 15, 15,087 (2025). https://doi.org/10.1038/s41598-025-98786-3
The University of Bayreuth’s Biomaterials research group has, for the first time, successfully applied the CRISPR-Cas9 gene-editing tool to spiders. Following the genetic modification, the spiders produced red fluorescent silk.
The findings of the study have been published in the journal Angewandte Chemie.
Spider silk is one of the most fascinating fibers in the field of materials science. In particular, its dragline thread is extremely tear-resistant, while also being elastic, lightweight and biodegradable. If scientists succeed in influencing spider silk production in vivo—in a living animal—and thereby gain insights into the structure of the dragline thread, it could pave the way for the development of new silk functionalities for a wide range of applications.
A recent discovery of a molecular connection between autism and myotonic dystrophy, a type of neuromuscular disease, may provide a breakthrough on how clinicians approach autism spectrum disorder.
The new study by an interdisciplinary team of biomedical scientists, published in Nature Neuroscience, used myotonic dystrophy as a tool or model to learn more about autism – effectively using one disorder to better understand the other.
“We identified a new pathway that can lead to autism,” said the research lead. “We found that a genetic mutation in a certain gene can disrupt the expression of multiple autism-related genes during brain development, causing autism.”