Toggle light / dark theme

Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential

Several multi-cancer GWAS loci within the region encoding telomerase reverse transcriptase (TERT) have been identified. Here, the authors explore the locus within TERT intron 4, link it with a variable number tandem repeat (VNTR), and investigate its biological significance and role in cancer.