Today, we would like to highlight a recent study in which researchers show a way to selectively accelerate bone regeneration. They have achieved this by delivering Jagged-1 to injuries instead of the bone morphogenetic proteins (BMPs) that have been traditionally used.
What is jagged-1?
Jagged-1 is an osteoinductive protein that activates the Notch signaling pathway, which regulates bone healing at the site of injury. Osteoinduction is the process by which osteogenesis is induced.
Researchers at UT Southwestern Medical Center have developed a CRISPR technique to efficiently correct the function of heart cells in patients with Duchenne muscular dystrophy (DMD). It involves making a single cut at strategic points along patient’s DNA, with the team claiming their new approach has the potential to correct most of the 3,000 mutations that cause DMD.
Duchenne muscular dystrophy (DMD) is one of nine neuromuscular disorders that affect the strength of muscles and nerves, specifically caused by defects in the gene that makes the dystrophin protein. Typically, one in every 3,500 boys born will be diagnosed with the disease at around three to four years of age, with their ability to walk gradually decreasing until they reach young adolescence. Most patients live until their 30s, but will require a wheelchair and respirator as the muscles in vital organs deteriorate over time.
A scientist cuts a DNA fragment under UV light for DNA sequencing. Image: AP Five years ago, when researchers first discovered that bacterial immune systems could be hijacked to edit DNA in living creatures, it was big news. The technology, called CRISPR, allowed scientists to more easily than ever cut and paste all those As, Cs, Ts, and Gs that make up the base pairs of DNA and encode the world’s living things. With CRISPR, scientists could use genetic engineering to tackle problems from disease to famine. But gene editing with CRISPR is so 2017. Recently, scientists have begun exploring n…
New Whitehead Institute research may prove to be a useful paradigm for targeting diseases caused by abnormal methylation. Credit: Steven Lee/Whitehead Institute Fragile X syndrome is the most frequent cause of intellectual disability in males, affecting one out of every 3,600 boys born. The syndrome can also cause autistic traits, such as social and communication deficits, as well as attention problems and hyperactivity. Currently, there is no cure for this disorder. Fragile X syndrome is caused by mutations in the FMR1 gene on the X chromosome, which prevent the gene’s expression. This abs…
Summary: Designer babies have recently become possible, as new techniques have gained credibility from serious scientists. Here’s how they can do it. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]
On Feb 8, the AHA named “Fixing a gene mutation in human embryos” as among the “top advances in heart disease and stroke research” of the past year. They joined a chorus of voices heralding this as a research breakthrough.
The announcement brought attention to the fact that US scientists have recently demonstrated the plausibility of using gene editing to make designer babies.
Summary: In a medical first, scientists at CWRU have inhibited metastasis – the spread of cancer cells to another part of the body. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]
In a first of its kind victory, researchers from the Case Western Reserve University (CWRU) School of Medicine and six other institutions have inhibited the spread of cancer cells from one part of the body to another.
To accomplish this feat, the team relied on a novel epigenetic model of how cancer metastasizes. Epigenetics is the master program which turns genes on and off. The group included researchers from the National Cancer Institute (NCI) and the Cleveland Clinic. The researchers published their results in the journal Nature Medicine.
