Lifeboat Foundation

In Brief

• Researchers have discovered that placing synthetic genetic circuits in liposomes prevents them from interfering with one another, while still allowing them to communicate.
• Not only could this new form of “modular” genetic circuits lead to more complex engineered circuits, it could also provide insight as to how the earliest life on Earth formed.

By applying engineering principles to biology, researchers can create biological systems that don’t exist naturally. A problem of synthetic biology, however, is that these engineered genetic circuits can interfere with each other. While beneficial on their own, some of these man-made circuits become useless when they come in contact with each other, and this bars them from being used to solve complex biological problems.

Continue reading “Researchers Just Solved One of the Biggest Problems in Synthetic Biology” »

SENS makes official comment on the excellent news about Mitochondrial repair from UCLA and Caltech.

So the big news is progress has been made on Mitochondrial repair. Our resident expert at the SENS Research Foundation, Dr. Matthew O’Connor of the MitoSENS project had this to say about the exciting news:

“New work from UCLA and Caltech has shown that a genetic pathway can be harnessed to selectively remove mutant mitochondria from the muscles of fruit flies. This work from Kandul et al is exciting because it raises the possibility of someday finding a way to control this genetic pathway in such a way to selectively delete mutant mitochondria. Further they did it in live flies in a tissue (muscle) where we are especially concerned about the impact of mitochondrial DNA mutations. Our ability to selectively control genetic pathways in non-genetically engineered animals (such as humans) is, however, extremely limited so it may be a long time before any clinical benefits can be realized from this research.” — Dr. Matthew O’Connor SRF

Continue reading “Turning back the aging clock” »

In China, there are fewer regulations and ethical quandaries standing in the way of genetic progress.

As the price of DNA sequencing drops, a new wave of consumer genomics companies is taking the science mainstream. Are you ready?

A world where DNA can be rewritten to fix deadly diseases has moved a step closer after scientists announced they had genetically-edited the cells of a human for the first time using a groundbreaking technique.

A man in China was injected with modified immune cells which had been engineered to fight his lung cancer. Larger trials are scheduled to take place next year in the US and Beijing, which scientists say could open up a new era of genetic medicine.

The technique used is called Crispr, which works like tiny molecular scissors snipping away genetic code and replacing it with new instructions to build better cells.

Continue reading “New era of ‘cut and paste’ humans close as man injected with genetically-edited blood” »

Encapsulating molecular components in artificial membranes offers more flexibility in designing circuits.

A genetic technique makes plants produce more food from sunlight — a key step in feeding the growing global population, scientists say.

Luv it! Wait until we make the marriage of QC meets Synbio — QC for the infrastructure and communications, and Synbio makes us all connected.

Cambridge, MA (Scicasts) — Synthetic biology allows scientists to design genetic circuits that can be placed in cells, giving them new functions such as producing drugs or other useful molecules. However, as these circuits become more complex, the genetic components can interfere with each other, making it difficult to achieve more complicated functions.

MIT researchers have now demonstrated that these circuits can be isolated within individual synthetic “cells,” preventing them from disrupting each other. The researchers can also control communication between these cells, allowing for circuits or their products to be combined at specific times.

Continue reading “Synthetic Cells to Isolate Genetic Circuits Created” »

A team of scientists in China has become the first to treat a human patient with the groundbreaking CRISPR-Cas9 gene-editing technique. While the results of the trial are uncertain, it’s a historic milestone that should serve as a serious wakeup call to the rest of the world.