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Archive for the ‘genetics’ category: Page 415

Sep 26, 2018

Genetic testing: Not a one-and-done deal

Posted by in categories: biotech/medical, genetics

That conclusion is based on a study that reviewed genetic testing results from 1.45 million individuals and found that nearly 25 percent of “variants of uncertain significance” were subsequently reclassified — sometimes as less likely to be associated with cancer, sometimes as more likely.

The study appears in the Journal of the American Medical Association (JAMA).

When variations from the norm are discovered in a gene, the variants are classified as “benign,” “likely benign,” “variant of uncertain significance,” “likely pathogenic,” or “pathogenic.”

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Sep 25, 2018

An Interview with Mike Bonkowski

Posted by in categories: biotech/medical, chemistry, genetics, life extension

Today, we have an interview with Dr. Michael Bonkowski, an expert on NAD+ biology and aging from the David Sinclair Lab, Harvard Medical School.

Michael Bonkowski aims to advance our understanding of the links between metabolism, aging, and age-associated diseases. He has published 35 peer-reviewed journal articles and has conducted multiple successful longevity studies. In Dr. David Sinclair’s lab, his research efforts are focused on the role of nutrient sensors’ regulation of endocrine signaling and aging in the mouse. He is also working on direct and indirect ways to drive the activity of these nutrient sensors by using dietary manipulations, small molecules, and chemical treatments.

Michael is trained as a pharmacologist, physiologist, and animal scientist. Some of his areas of expertise include animal physiology, genetics, glucose, and insulin homeostasis, metabolism, assay development, protein biochemistry, and transmission electron microscopy imaging.

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Sep 25, 2018

Bioquark Inc. — Reader’s Digest (15 Cool Future Jobs) — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, DNA, futurism, genetics, health, life extension, posthumanism, science

Sep 23, 2018

Study of one million people leads to world’s biggest advance in blood pressure genetics

Posted by in categories: biotech/medical, genetics

Over 500 new gene regions that influence people’s blood pressure have been discovered in the largest global genetic study of blood pressure to date, led by Queen Mary University of London and Imperial College London.

Involving more than one million participants, the results more than triple the number of gene regions to over 1,000 and means that almost a third of the estimated heritability for pressure is now explained.

The study, published in Nature Genetics and supported by the National Institute for Health Research (NIHR), Medical Research Council and British Heart Foundation, also reports a strong role of these genes, not only in blood vessels, but also within the adrenal glands above the kidney, and in body fat.

Continue reading “Study of one million people leads to world’s biggest advance in blood pressure genetics” »

Sep 22, 2018

Glimpse: On the Promise of a Future with Artificial Wombs, and Why It’s Being Stopped by the Present

Posted by in categories: biotech/medical, genetics, transhumanism

Given the speed at which reproductive technology has advanced over the past few decades, it doesn’t feel all that far-fetched: A future in which anyone can have a baby, regardless of creed or need, whenever they feel like it. Already, in our present moment, one can buy or sell eggs and sperm; we can give embryos genetic tests to ensure the children they produce don’t have any life-threatening hereditary conditions; and babies can even be born, now, with the genetic information from three parents.

So it follows that we should soon be able to to have pregnancy outside the body — artificial wombs. R ight?

Continue reading “Glimpse: On the Promise of a Future with Artificial Wombs, and Why It’s Being Stopped by the Present” »

Sep 21, 2018

Bioquark Inc. — The Health Hub Podcast — Ira S. Pastor

Posted by in categories: aging, bioengineering, biotech/medical, DNA, futurism, genetics, health, life extension, science, transhumanism

Sep 21, 2018

Bioquark Inc. — Unlimited Realities Podcast — Ira S. Pastor

Posted by in categories: aging, bioengineering, biological, biotech/medical, cryonics, DNA, futurism, genetics, life extension, transhumanism

http://www.blogtalkradio.com/unlimited-realities-with-lisa-z…lth-future

Sep 20, 2018

A cure for aging: where do we stand today?

Posted by in categories: biotech/medical, genetics, life extension

If you are able to get to Leiden there is an event in support of Lifespan.io on September 29, 12:00 AM – 2:00 PM CEST.


Ending aging and getting rid of its associated conditions is one of humanity’s most ancient dreams. Some of our earliest myths are about heroes going on a quest to find a way to make the whole of mankind forever young. With the current progress in aging research, this is not a dream anymore. In laboratories around the globe, researchers are conducting experiments that show that aging is amenable to medical intervention; we can slow it down and even reverse some age-related changes. As recent experiments on mice demonstrate, there are various ways to postpone aging. Among the most promising treatments are the elimination of harmful senescent cells, drugs that enhance metabolism, genetic and cellular therapies, and calorie restriction. These treatments extend the healthy period of life, and, as a welcome side effect, lifespan in mice by over 25–30%. Some of these methods are currently in human clinical trials and are expected to reach the market 5–10 years from now.

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Sep 18, 2018

High blood pressure breakthrough: Over 500 genes uncovered

Posted by in categories: biotech/medical, genetics

The world’s largest genetic study of hypertension finds that the number of genetic loci involved is three times larger than previously thought.

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Sep 18, 2018

Representing a “revolution”: how the popular press has portrayed personalized medicine

Posted by in categories: biotech/medical, genetics

This study investigated the portrayal of “personalized” and “precision” medicine (PM) in North American news over the past decade. Content analysis of print and online news was conducted to determine how PM has been defined and to identify the frames used to discuss PM, including associated topics, benefits, and concerns.

A data set was built using the FACTIVA database, searching for popular North American publications with the terms “personalized (personalised) medicine” and/or “precision medicine” from 1 January 2005 to 15 March 2016. The final set of publications totaled 774.

PM is almost exclusively defined as related to genetics and is often part of a story related to cancer. The PM story is overwhelmingly one of highlighting (potential) benefits and optimism, especially in shorter publications, and ones where PM is not the main focus. This promotional PM discourse has remained fairly consistent over the past decade.

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