Lifeboat Foundation

A very good article on the studies on centenarians of Okinawa, on the importance of carbohydrate / protein ratio in diet, genes, calorie restriction and more: “… Genetic good fortune could be one important factor. Thanks to the geography of the islands, Okinawa’s populations have spent large chunks of their history in relative isolation, which may has given them a unique genetic profile. Preliminary studies suggest this may include a reduced prevalence of a gene variant – APOE4 – that appears to increase the risk of heart disease and Alzheimer’s. They may also be more likely to carry a protective variant of the FOXO3 gene involved in regulating metabolism and cell growth. This results in a shorter stature but also appears to reduce the risk of various age-related diseases, including cancer. Even so, it seems unlikely that good genes would fully explain the Okinawans’ longevity, and lifestyle factors will also be important…”

Emerging evidence suggests a 10:1 ratio of carbohydrates to proteins may protect the body from the ravages of ageing.

You can now perform CRISPR gene-editing in your kitchen!

Biologists have demonstrated for the first time that a controversial genetic engineering technology works, with caveats, in mammals.

We’ve all seen the stark headlines: “Being Rich and Successful Is in Your DNA” (Guardian, July 12); “A New Genetic Test Could Help Determine Children’s Success” (Newsweek, July 10); “Our Fortunetelling Genes” make us (Wall Street Journal, Nov. 16); and so on.

The problem is, many of these headlines are not discussing real genes at all, but a crude statistical model of them, involving dozens of unlikely assumptions. Now, slowly but surely, that whole conceptual model of the gene is being challenged.

We have reached peak gene, and passed it.

Continue reading “It’s the End of the Gene As We Know It” »

A Chinese scientist who created what he said were the world’s first “gene-edited” babies evaded oversight and broke ethical boundaries in a quest for fame and fortune, state media said on Monday, as his former university said he had been fired.

He Jiankui said in November that he used a gene-editing technology known as CRISPR-Cas9 to alter the embryonic genes of twin girls born that month, sparking an international outcry about the ethics and safety of such research.

Hundreds of Chinese and international scientists condemned He and said any application of gene editing on human embryos for reproductive purposes was unethical.

Continue reading “Chinese scientist who gene-edited babies fired” »

2019 will likely see gene drives used in the wild, a universal flu vaccine, further advance of brain-machine interfaces, and more.

Researchers have demonstrated for the first time how two molecular strategies can safeguard CRISPR gene-drive experiments in the lab, according to a study published today in eLife.

Salk researchers have mapped the genomes and epigenomes of genetically modified plant lines with the highest resolution ever to reveal exactly what happens at a molecular level when a piece of foreign DNA is inserted. Their findings, published in the journal PLOS Genetics on January 15, 2019, elucidate the routine methods used to modify plants, and offer new ways to more effectively minimize potential off-target effects.

The future of medicine involves the precise engineering of human cells. Turns out, that future may not include that promising CRISPR technique.