Archive for the ‘genetics’ category: Page 395
Aug 6, 2018
What is Autophagy? Definition, Benefits, 25 Ways to Increase It
Posted by Manuel Canovas Lechuga in categories: genetics, health
Autophagy is how our cells recycle their components. Most of the time it runs quietly in the background. But when cells are stressed (such as during fasting or in the presence of dysfunctional proteins) it is increased in order to protect us. Read on to learn about autophagy, its definition and how it works, autophagy regulation, and how to increase autophagy through things like fasting.
Discover the exact, genetic factors in your body that are affecting autophagy with SelfDecode, the most powerful genetic health analysis tool available.
Aug 4, 2018
Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women
Posted by Manuel Canovas Lechuga in categories: biotech/medical, genetics, life extension
Evolutionary theory predicts that reproduction entails costs that detract from somatic maintenance, accelerating biological aging. Despite support from studies in human and non-human animals, mechanisms linking ‘costs of reproduction’ (CoR) to aging are poorly understood. Human pregnancy is characterized by major alterations in metabolic regulation, oxidative stress, and immune cell proliferation. We hypothesized that these adaptations could accelerate blood-derived cellular aging. To test this hypothesis, we examined gravidity in relation to telomere length (TL, n = 821) and DNA-methylation age (DNAmAge, n = 397) in a cohort of young (20–22 year-old) Filipino women. Age-corrected TL and accelerated DNAmAge both predict age-related morbidity and mortality, and provide markers of mitotic and non-mitotic cellular aging, respectively. Consistent with theoretical predictions, TL decreased (p = 0.031) and DNAmAge increased (p = 0.007) with gravidity, a relationship that was not contingent upon resource availability. Neither biomarker was associated with subsequent fertility (both p 0.3), broadly consistent with a causal effect of gravidity on cellular aging. Our findings provide evidence that reproduction in women carries costs in the form of accelerated aging through two independent cellular pathways.
Jul 30, 2018
Bioquark Inc. — Future Tech Podcast — Ira Pastor
Posted by Ira S. Pastor in categories: aging, bioengineering, biological, business, cryonics, futurism, genetics, health, neuroscience, transhumanism
Jul 30, 2018
An Interview With Dr. João Pedro de Magalhães
Posted by Nicola Bagalà in categories: biotech/medical, genetics, life extension
A new interview on LEAF with biogerontologist Dr. João Pedro de Magalhães.
Today, we have an interview with Dr. João Pedro de Magalhães, the biogerontologist who created and runs senescence.info. In the unlikely event that his name is new to you, we had another interview with him last year, which you can check out here.
How do you think we age; are we programmed to die, do we wear out, or is the truth a mixture of both?
Continue reading “An Interview With Dr. João Pedro de Magalhães” »
Jul 28, 2018
Robots Can’t Make Us Safer Until We Figure Out The Division Of Labor
Posted by Dan Kummer in categories: genetics, robotics/AI, transportation
The risk of serious accidents will persist whenever people and machines share responsibility for safety.
An Uber “safety driver” takes journalists on a drive through the streets of downtown Pittsburgh in an automonous vehicle in September of 2016. (AP Photo/Gene J. Puskar)
Jul 28, 2018
Communities Raise Their Voices on Genetic Engineering
Posted by Dan Kummer in categories: bioengineering, genetics
From Martha’s Vineyard to New Zealand, the power of new genetic tools provokes concern and collaboration.
Crispr technology may allow scientists to change the environment forever, but working with the affected localities presents a challenge.
Jul 28, 2018
A Major Drug Company Now Has Access to 23andMe’s Genetic Data. Should You Be Concerned?
Posted by Derick Lee in categories: biotech/medical, genetics, privacy
Consumer genetic testing company 23andMe announced on Wednesday that GlaxoSmithKline purchased a $300 million stake in the company, allowing the pharmaceutical giant to use 23andMe’s trove of genetic data to develop new drugs — and raising new privacy concerns for consumers.
23andMe is partnering with big pharma company GlaxoSmithKline. Here’s what that means for consumer rights and genetic privacy.
Jul 26, 2018
Dads Pass On More Than Genetics in Their Sperm
Posted by Genevieve Klien in category: genetics
Seminal research reveals that sperm change their cargo as they travel the reproductive tract—and the differences can have consequences for fertility.
Jul 24, 2018
Mice Reprogram Gut Tissue to a Fetal State to Heal Injury
Posted by Steve Hill in categories: biotech/medical, genetics, life extension, neuroscience
A new study shows that mice reprogram their gut tissues to repair injury rolling them from an aged state back to a more fetal-like one.
Getting old is one thing; getting old in a healthy way is another. Many elderly people suffer from all kinds of diseases and disorders, ranging from cardiovascular problems and diabetes to Alzheimer’s and Parkinson’s disease. Wouldn’t it be nice if we could keep the body young as we grow older to prevent disease associated with old age? For instance, would it be possible to slow down or reverse the aging processes in the cells of our body?
This question has gained a lot of interest from scientists, and their research has led to the discovery of the important role that the shortening of telomeres, the protective caps on our DNA, plays in aging. While this has been described in recent posts on the LEAF blog, I would like to address another mechanism that has seen an interesting leap forward, more or less by accident: rejuvenation of tissue.
Continue reading “Mice Reprogram Gut Tissue to a Fetal State to Heal Injury” »