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Category: genetics – Page 39

Stress could affect the development of the fetal brain

Disruptions in brain development are linked to higher risks of brain and mental illnesses. While genetics are known to play a role, environmental factors at the molecular and cellular levels have been less studied.

The international team of researchers from Karolinska Institutet, the Max Planck Institute of Psychiatry, and Helmholtz Munich aimed to understand how glucocorticoids — hormones involved in the body’s stress response and crucial for normal fetal development — affect brain development when overexposed.

The findings reveal that fetuses are more vulnerable to external influences like stress than previously thought. This stress can impact fetal brain development.

NanoCas, a smaller version of CRISPR tested with a single AAV, delivers on-target results

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform gene editing in non-liver tissues, including skeletal muscle, using a single adeno-associated virus (AAV) vector. Experiments in non-human primates (NHPs) resulted in editing efficiencies exceeding 30% in muscle tissues.

CRISPR gene editing has revolutionized genetics, but delivery challenges have restricted its clinical applications primarily to ex vivo and liver-directed therapies. Conventional CRISPR nucleases, including Cas9 and Cas12a, exceed the packaging limits of a single AAV vector, necessitating dual-AAV strategies that reduce efficiency.

Smaller CRISPR systems such as Cas12i and CasX have been identified, but they remain too large or exhibit low editing efficiency. Existing compact systems like Cas14 and IscB have not demonstrated robust efficacy in large animal models.

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AI Reveals How Brain Cells Evolved Over 320 Million Years

Summary: A new study reveals how AI-driven deep learning models can decode the genetic regulatory switches that define brain cell types across species. By analyzing human, mouse, and chicken brains, researchers found that some brain cell types remain highly conserved over 320 million years, while others have evolved uniquely.

This regulatory code not only sheds light on brain evolution but also provides new tools for studying gene regulation in health and disease. The findings highlight how AI can identify preserved and divergent genetic instructions controlling brain function across species.

The study also has implications for understanding neurological disorders by linking genetic variants to cognitive traits. Researchers are now expanding their models to study the brains of various animals and human disease states like Parkinson’s.

New smart jacket uses AI to prevent overheating and discomfort

In Europe alone, approximately 2 million people live with chronic inflammatory bowel diseases (IBD), and their incidence has been rising steadily in recent decades. However, a small proportion of the European population carries a genetic variant that provides natural protection against IBD.

A newly published study in the journal eBioMedicine explores how this protective variant can be leveraged to develop modern therapies, demonstrating the potential of evolutionary medicine in addressing chronic diseases of the modern era.

The study, led by the Institute of Clinical Molecular Biology (IKMB) at Kiel University, brought together researchers from genetics, medicine, and archaeology.

Mouse model unveils dynamics through which SYNGAP1 gene supports cognitive function

The SYNGAP1 gene, which supports the production of a protein called SynGAP (Synaptic Ras GTPase-Activating Protein), is known to play a key role in supporting the development of synapses and neural circuits (i.e., connections between neurons). Mutations in this gene have been linked to various learning disabilities, including intellectual disabilities, speech and language delays, autism spectrum disorder (ASD), and epilepsy.

Researchers at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology recently carried out a study aimed at better understanding the via which the SYNGAP1 gene contributes to healthy cognitive function. Their findings, published in Nature Communications, suggest that the autonomous expression of this gene in the cortical excitatory neurons of mice promotes the animals’ cognitive abilities via the assembly of long-range integrating sensory and motor information.

“Our paper builds on our ongoing research into how major risk genes for mental health disorders, including autism, regulate brain organization and function,” Gavin Rumbaugh, senior author of the paper, told Medical Xpress. “The field knows the major risk genes that directly contribute to cognitive and behavioral impairments that lead to diagnosable forms of autism and related neuropsychiatric disorders in humans.

Gene-edited rice can produce a compound that’s vital for human health

A team of Chinese scientists has used targeted gene editing to develop rice that produces coenzyme Q10 (CoQ10), a vital compound for human health.

Led by Prof. Chen Xiaoya from the CAS Center for Excellence in Molecular Plant Sciences/Shanghai Chenshan Research Center and Prof. Gao Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS), the researchers used targeted gene editing to modify just five amino acids of the Coq1 rice enzyme, creating new rice varieties capable of synthesizing CoQ10.

The study is published in Cell.

Deep learning provides new view on 300 million years of brain evolution

In a new study published in Science, a Belgian research team explores how genetic switches controlling gene activity define brain cell types across species. They trained deep learning models on human, mouse, and chicken brain data and found that while some cell types are highly conserved between birds and mammals after millions of years of evolution, others have evolved differently.

The findings not only shed new light on evolution; they also provide powerful tools for studying how shapes different cell types, across species or different disease states.

Our brain, and by extension our entire body, is made up of many different types of cells. While they share the same DNA, all these cell types have their own shape and function. What makes each cell type different is a complex puzzle that researchers have been trying to put together for decades from short DNA sequences that act like switches, controlling which genes are turned on or off.

Nanoparticles successfully deliver genetic material to plants via roots

University of Queensland researchers have for the first time introduced genetic material into plants via their roots, opening a potential pathway for rapid crop improvement. The research is published in Nature Plants.

Professor Bernard Carroll from UQ’s School of Chemistry and Molecular Biosciences said nanoparticle technology could help fine-tune plant genes to increase crop yield and improve food quality.

“Traditional plant breeding and take many generations to produce a new crop variety, which is time-consuming and expensive,” Professor Carroll said.