1. Various tissues will have different safe zones of rejuvenation before they become pluripotent but we could make tissue specific treatments and treat them separately without effecting others.
2. A 40 year old woman makes a 40 year old egg but that egg is rejuvenated to its younger state with no damage after fertilization.
This Review provides a comprehensive overview of presynaptic applications of optogenetic tools, including the associated challenges, current limitations and future directions for this approach.
Gene editing with CRISPR can cause off-target mutations, but this seems to happen less often with an enzyme that cuts one of the strands of DNA instead of both.
The team of researchers who transplanted a genetically modified pig’s heart into a living human earlier this year have completed two more pig heart transplant surgeries, setting the protocol for such operations.
In January this year, 57-year-old David Bennett became the first man on the planet to receive a heart from a genetically modified pig. Before this, researchers transplanted kidneys from similarly modified pigs into patients that were brain dead.
The organs are sourced from a company called Revivicor which uses genetic engineering to remove specific genes in the pigs to help in reducing transplant rejection while adding some that make the organs more compatible with the human immune system.
𝘼𝙣 𝙞𝙣𝙩𝙚𝙧𝙣𝙖𝙩𝙞𝙤𝙣𝙖𝙡 𝙩𝙚𝙖𝙢 𝙤𝙛 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙡𝙚𝙙 𝙗𝙮 𝙐𝘾 𝘿𝙖𝙫𝙞𝙨 𝙜𝙚𝙣𝙚𝙩𝙞𝙘𝙞𝙨𝙩 𝙎𝙪𝙢𝙖 𝙎𝙝𝙖𝙣𝙠𝙖… See more.
An international team of researchers led by UC Davis geneticist Suma Shankar has discovered a new gene implicated in a neurodevelopmental condition called DPH5-related diphthamide-deficiency syndrome. The syndrome is caused by DPH5 gene variants that may lead to embryonic death or profound neurodevelopmental delays.
Findings from their study were published in Genetics in Medicine.
“We are so excited about the novel gene discovery,” said the lead author Suma Shankar, professor in the Departments of Pediatrics and Ophthalmology and faculty at the UC Davis MIND Institute. Shankar is the director of Precision Genomics, Albert Rowe Endowed Chair in Genetics, and chief of Division of Genomic Medicine.
Distinct neuron types in the auditory organ are necessary for encoding different features of sound and relaying them to the brain. Researchers at Karolinska Institutet provide evidence of an early, neuronal activity-independent, emergence of the different subtypes of auditory neurons, prior to birth in mice. The findings have recently been published in Nature Communications.
Previous studies have provided ambiguous results on whether the different subtypes of auditory neurons emerge during prenatal or postnatal development, with in the latter case, a possible role of neuronal activity in generating their diversity. In this new study, researchers demonstrate that the fate of auditory neuron subtypes is under genetic control in the prenatal period, and reveal the complex molecular networks controlling their genesis.
Gregor Mendel, the Moravian monk, was indeed “decades ahead of his time and truly deserves the title of ‘founder of genetics.’” So concludes an international team of scientists as the 200th birthday of Mendel approaches on 20 July.
The team, from KeyGene in the Netherlands and the John Innes Centre in the UK, draw on newly-discovered historical information to conclude that, when his proposals are viewed in the light of what was known of cells in the mid-19th century, Mendel was decades ahead of his time.
“Uncovering hidden details about Mendel has helped to build a picture of the scientific and intellectual environment in which he worked. At the outset Mendel knew nothing about genetics and had to deduce it all for himself. How he went about this is highly instructive,” said Dr. Noel Ellis from the John Innes Centre, one of the contributors to the study.
In this landmark talk, Peter Diamandis shares how we are rapidly heading towards a human-scale transformation, the next evolutionary step into what he calls a “Meta-Intelligence,” a future in which we are all highly connected — brain to brain via the cloud — sharing thoughts, knowledge and actions. He highlights the 4 driving forces as well as the 4 steps that is transforming humanity.
In 2014 Fortune Magazine named Peter Diamandis as one of the World’s 50 Greatest Leaders.
Diamandis He is the Founder & Executive Chairman of the XPRIZE Foundation which leads the world in designing and operating large-scale incentive competitions. He is also the Co-Founder & Exec Chairman of Singularity University, a graduate-level Silicon Valley institution that counsels the world’s leaders on exponentially growing technologies.
As an entrepreneur, Diamandis has started 17 companies. He is the Co-Founder and Vice-Chairman of Human Longevity Inc. (HLI), a genomics and cell therapy-based company focused on extending the healthy human lifespan, and Co-Founder and Co-Chairman of Planetary Resources, a company designing spacecraft to enable the detection and prospecting of asteroid for fuels and precious materials.
Peter Diamandis earned degrees in Molecular Genetics and Aerospace Engineering from the MIT, and holds an M.D. from Harvard Medical School.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community.