A genetic tweak can make cells self-destruct in the presence of CRISPR and could be used to shut down cell therapies if they go rogue.
In some biology classes, teachers will place vials of spit into a funny looking contraption and let it spin around the samples until the stringy DNA separates from the rest of the saliva. It’s a pretty rudimentary experiment, but it quickly gets to the heart of not only your own genetic material, but also how centrifugal force works: Spinning really fast in a circle creates a force strong enough to push a moving object out and away from the center of its path.
But what happens when that moving object is a rocket that weighs thousands of pounds? We might find out as soon as this year, when a cryptic startup called SpinLaunch starts suborbital test flights of a rocket that is launched using an enormous centrifuge.
Here’s the gist: A centrifuge the size of a football field will spin a rocket around in circles for about an hour until its speed eventually exceeds 5,000 miles per hour. At that point, the rocket and its payload will feel forces 10,000 times stronger than gravity. When the centrifuge finally releases the rocket at launch speed, it should, practically speaking, fly through the stratosphere until it fires its engines at the periphery of our atmosphere.
And the revolution has already begun.
Today’s genetic moment is not the stuff of science fiction. It’s not Jules Verne’s fanciful 1865 prediction of a moon landing a century before it occurred. It’s more equivalent to President Kennedy’s 1962 announcement that America would send men to the moon within a decade. All of the science was in place when Kennedy gave his Houston speech. The realization was inevitable; only the timing was at issue. Neil Armstrong climbed down the Apollo 11 ladder seven years later.
HONG KONG, Feb. 11, 2020 /PRNewswire/ — Infectious diseases represent an important portion of global public health concerns¸ in particular with regard to the current global outbreak of novel coronavirus (2019-nCoV). The challenge of frontline diagnosis in hospitals, clinics and ports is that infectious diseases could exhibit similar symptoms or can be asymptomatic. The Hong Kong Polytechnic University (PolyU) today announced the development of the world’s most comprehensive automated multiplex diagnostic system (the System) which includes a fully automated machine and a multiplex full-screening panel for the point-of-care genetic testing (POCT) of respiratory infectious disease including the 2019-nCoV.
In October 2019, Liu and his colleagues published a paper in Nature, describing an even newer technology, called prime editing. Prime editing can not only make all twelve of the possible base substitutions, it can also make multiple-base insertions or deletions, without requiring a double-strand break. It achieves this with a multi-step operation that first cuts one strand, then performs the appropriate substitution, insertion, or deletion, and then nicks the second strand to allow the bases on the second strand to be replaced by bases that complement the ones substituted, inserted into or deleted from the first strand. The result is a modified stretch of DNA that had never been completely separated. This has the effect of massively reducing the number of off-target modifications.
This new prime editing variant of CRISPR technology, can make the same corrections to the defects that cause sickle cell disease and beta-thalassemia that standard CRISPR/Cas9 has now made in human subjects, but with less opportunity for unwanted off-target changes. Furthermore, its possible applicability is much wider. The ClinVar database lists over 75,000 pathogenic mutations in the human genome. Of these, over 89% are potentially correctable by prime editing.
Continue reading “Gene Editing is Advancing at Breakneck Speed” »
Newborn screening covers more than 30 conditions. Yet, with genome sequencing, we could screen newborns for several thousand genetic conditions.
In the surveys’ open-ended responses about risks of genome sequencing, parents and clinicians both expressed concerns about psychological distress related to difficult or uncertain results. Clinicians were more likely to raise concerns about returning results for adult-onset conditions, unnecessary parental stress over health problems that might never actually occur, and the possibility of future discrimination against the child on the basis of their genomic information.
Continue reading “Is It Too Soon to Consider Genome Sequencing for Newborns?” »
Bill-gates-thinks-gene-editing-artificial-intelligence-save-world.
Microsoft co-founder Bill Gates has been working to improve the state of global health through his nonprofit foundation for 20 years, and today he told the nation’s premier scientific gathering that advances in artificial intelligence and gene editing could accelerate those improvements exponentially in the years ahead.
“We have an opportunity with the advance of tools like artificial intelligence and gene-based editing technologies to build this new generation of health solutions so that they are available to everyone on the planet. And I’m very excited about this,” Gates said in Seattle during a keynote address at the annual meeting of the American Association for the Advancement of Science.
Dr. Theodore Ho talks about the rapidly expanding possibilities of stem cells to be used in reversing or slowing the aging process. He discusses his previous and current work with the brain, including such methods as tissue clearing, multifiber photometry and optogenetics, and single resolution calcium imaging and control. Dr. Ho is a neuroscientist and stem cell biologist studying the mechanisms and causes of biological aging and potential strategies to slow or reverse them, in order to prevent the onset of age
Associated diseases to help us live healthier and longer lives.
Continue reading “Aging and Stem Cells | Theodore Ho | TEDxMiddlebury” »
AZOKH, Nagorno-Karabakh (People of Ar)—Scholars from Britain, US, Denmark and Armenia led by Professor Levon Yepiskoposyan have been examining prehistoric caves near the village of Azokh in Artsakh (Nagorno Karabakh) and found unique artifacts from different periods, among them a tooth from a human who lived 7000 years ago. Due to the cave’s climate DNA was preserved inside the tooth and was send to Copenhagen University’s genetics department (in Denmark) for examination. The results of this inquiry have revealed that the genetic makeup of the tooth belonging to an individual 7000 years ago perfectly matches with the genetic makeup of modern Armenians.
“This is the conclusion we’ve reached after numerous excavations carried out on the territory of Karabakh, where we examined more than a dozen caves, among them the cave of Azokh and Alexan Uzes,” Yepiskoposyan said.
An American biotech company says it created a coronavirus vaccine three hours after getting access to the virus’ genetic sequence in mid-January, and now scientists are racing to get the vaccine on the market in record time.
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Inovio Pharmaceuticals is based in Pennsylvania, but scientists in its laboratory in San Diego made the discovery.
