Modifying brain cell activity can extend the lifespan of fruit flies while also preventing the damage characteristic of Alzheimer’s disease, finds a new study led by UCL researchers.
Category: genetics – Page 333
Tissue Rejuvenation via Plasma Dilution | Irina Conboy, UC Berkeley
This is a detailed summary of plasma dilution and at 58:38 the future is explained where they will publish human results from 25 people, then start a company whose first order of business will be phase 3 trials with more people and placebo and hopefully funding. It appears you can pay to have the procedure. The hopeful start is this year in may.
Irina will present her recent findings on plasma dilution, showing that age-reversing effects, such as rejuvenating tissues in mice, can be achieved by.
diluting the blood plasma of old mice: Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.
Irina’s research focus.
A key direction of my laboratory is to understand age-imposed and pathological changes in molecular compositions of systemic and local environments of adult stem cells and to calibrate these to health — youth. In the past few years this direction has been ramified into synthetic biology, CRISPR technologies, bio-orthogonal proteomics and development of innovative digital bio-sensors that we collaboratively applied to the fields of aging and diagnostics of genetic diseases. Success in this research will improve our understanding of the determinants of homeostatic health and will enable novel rational approaches to treat a number of degenerative, fibrotic, metabolic and inflammatory diseases, as a class.
Zoom Transcription:
https://otter.ai/u/yhmNLEM7V52oOfW93lUfDWqL_uw
Suppressor genes linked to less cancer and longer lifespan found in whales
A trio of researchers with ICAEV, Universidad Austral de Chile, and the University of Liverpool, respectively, have found suppressor genes linked to longevity and less cancer in two species of whales. In their paper published in the journal Proceedings of the Royal Society B, Daniela Tejada-Martinez, João Pedro de Magalhães and Juan C. Opazo, describe their genetic study of longevity in cetaceans and what they learned.
The Future of Genetic Engineering — George Church
Code of the Wild (Documentary) at Hello Tomorrow in Paris.
www.codeofthewild.org to watch the trailer and explore the film.
George Church, Antonio Regalado, and Josiah Zayner discuss designer babies, moratorium on human germ line engineering, and the future of the genomic revolution with Jane Metcalfe, co-founder of Wired Magizine and founder of Neolife (https://neo.life/)
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Samira Kiani
Kazuo Ishiguro: ‘AI, gene-editing, big data … I worry we are not in control of these things any more’
😃
The Nobel-winning author talks about scaring Harold Pinter, life after death – and his new novel about an ‘artificial friend’
1st clone of U.S. endangered species is ferret created from genes of animal dead for 3 decades
HOW CUTE 🥰 Meet Elizabeth Ann, the first-ever cloned U.S. endangered species. She’s a black-footed ferret duplicated from the genes of an animal that died in 1988.
“You might have been handling a black-footed ferret kit and then they try to take your finger off the next day,” U.S. Fish and Wildlife Service black-footed ferret recovery coordinator Pete Gober said Thursday. “She’s holding her own.”
Elizabeth Ann was born and is being raised at a Fish and Wildlife Service black-footed ferret breeding facility in Fort Collins, Colorado. She’s a genetic copy of a ferret named Willa who died in 1988 and whose remains were frozen in the early days of DNA technology.
Cloning eventually could bring back extinct species such as the passenger pigeon. For now, the technique holds promise for helping endangered species including a Mongolian wild horse that was cloned and last summer born at a Texas facility.
Reverse Age
This is the FIRST part of the interview with Rodolfo Goya.
In this video Professor Goya talks about his role in the original experiment and the progress in his current study to reproduce the results with young blood plasma.
Professor Rodolfo Goya is Senior Scientist at The National Scientific and Technical Research Council in Argentina where he is a biochemist and researcher.
Dr. Goya has led a number of studies on cellular reprogramming and restoration of function in important organs, such as the thymus and the brain. He is also studying different aspects of cryopreservation.
He was one of the authors of the paper “Reversing age: dual species measurement of epigenetic age with a single clock” and is now working in his lab to reproduce and extend the results.
20% of People Have a Genetic Mutation That Provides Superior Resilience to Cold
Almost one in five people lack the protein α-aktinin-3 in their muscle fiber. Researchers at Karolinska Institutet in Sweden now show that more of the skeletal muscle of these individuals comprises slow-twitch muscle fibers, which are more durable and energy-efficient and provide better tolerance to low temperatures than fast-twitch muscle fibers. The results are published in the scientific journal The American Journal of Human Genetics.
Skeletal muscle comprises fast-twitch (white) fibers that fatigue quickly and slow-twitch (red) fibers that are more resistant to fatigue. The protein α-aktinin-3, which is found only in fast-twitch fibers, is absent in almost 20 percent of people – almost 1.5 billion individuals – due to a mutation in the gene that codes for it. In evolutionary terms, the presence of the mutated gene increased when humans migrated from Africa to the colder climates of central and northern Europe.
“This suggests that people lacking α-aktinin-3 are better at keeping warm and, energy-wise, at enduring a tougher climate, but there hasn’t been any direct experimental evidence for this before,” says Håkan Westerblad, professor of cellular muscle physiology at the Department of Physiology and Pharmacology, Karolinska Institutet. “We can now show that the loss of this protein gives a greater resilience to cold and we’ve also found a possible mechanism for this.”