Lifeboat Foundation

What is the deadliest animal on earth? It’s a question that brings to mind fearsome lions, tigers, sharks, and crocodiles. But the answer is an animal that is no more than 1 centimeter long.

A few mosquito species, out of the thousands that populate different environments, are the deadliest animals on earth. Anopheles mosquitoes alone, transmit malaria through their bite and annually infect more than 200 million people, and are responsible for 400,000 deaths per year, of which 70 percent are children under the age of 5.

Other mosquito species also transmit diseases — dengue, West Nile, and Zika — through their bite.

Continue reading “Scientists Fight Back Against Deadliest Animal on Earth Using ‘Gene Drives’” »

Many scientists research the practical and immediate applications of bio molecular technology but it seems most fail to study our most important, and largest organ, our skin.

Who will officially be the first transhuman? Will it be you? Why wait decades? This article explains one approach to speeding up the process and also the challenge involved.

Defining the Object of the Goal:

Continue reading “Becoming the First Transhuman: A Call For The Right Stuff” »

Popular spit-in-a-tube genetics-testing companies like Ancestry and 23andMe can — and frequently do — sell your data to drugmakers. But on Wednesday, one of those partnerships became much more explicit, when the pharmaceutical giant GlaxoSmithKline announced it was acquiring a $300 million stake in 23andMe.

As part of a four-year deal between the two companies, GlaxoSmithKline will comb 23andMe’s genetic data to look for new drugs to develop, also referred to as drug targets. It will also use the genetic data to inform how patients are selected for clinical trials.

If that news has you thinking about how your own genetic material is being used for research, know that though the DNA you submit to these services is ostensibly anonymized, leaks can happen, and privacy advocates say that such incidents could allow your data to find its way elsewhere, perhaps without your knowledge.

Continue reading “DNA-testing company 23andMe has signed a $300 million deal with a drug giant. Here’s how to delete your data if that freaks you out” »

University of Arizona biomedical engineering professor Philipp Gutruf is first author on the paper Fully implantable, optoelectronic systems for battery-free, multimodal operation in neuroscience research, published in Nature Electronics.

Optogenetics is a biological technique that uses light to turn specific neuron groups in the brain on or off. For example, researchers might use optogenetic stimulation to restore movement in case of paralysis or, in the future, to turn off the areas of the brain or spine that cause pain, eliminating the need for—and the increasing dependence on—opioids and other painkillers.

“We’re making these tools to understand how different parts of the brain work,” Gutruf said. “The advantage with optogenetics is that you have cell specificity: You can target specific groups of neurons and investigate their function and relation in the context of the whole brain.”

Continue reading “Controlling neurons with light—but without wires or batteries” »

A Chinese scientist has claimed to use CRISPR to genetically engineer two babies. An expert explains what this means and the ethical implications.

Here, we will first summarize the experimental achievements over the last 7 years in cell and animal rejuvenation. Then, a comparison will be made between the principles of the cumulative DNA damage theory of aging and the basic facts underlying the epigenetic model of aging, including Horvath’s epigenetic clock. The third part will apply both models to two natural processes, namely, the setting of the aging clock in the mammalian zygote and the changes in the aging clock along successive generations in mammals. The first study demonstrating that skin fibroblasts from healthy centenarians can be rejuvenated by cell reprogramming was published in 2011 and will be discussed in some detail. Other cell rejuvenation studies in old humans and rodents published afterwards will be very briefly mentioned. The only in vivo study reporting that a number of organs of old progeric mice can be rejuvenated by cyclic partial reprogramming will also be described in some detail. The cumulative DNA damage theory of aging postulates that as an animal ages, toxic reactive oxygen species generated as byproducts of the mitochondria during respiration induce a random and progressive damage in genes thus leading cells to a progressive functional decline. The epigenetic model of aging postulates that there are epigenetic marks of aging that increase with age, leading to a progressive derepression of DNA which in turn causes deregulated expression of genes that disrupt cell function. The cumulative DNA damage model of aging fails to explain the resetting of the aging clock at the time of conception as well as the continued vitality of species as millenia go by. In contrast, the epigenetic model of aging straightforwardly explains both biologic phenomena. A plausible initial application of rejuvenation in vivo would be preventing adult individuals from aging thus eliminating a major risk factor for end of life pathologies. Further, it may allow the gradual achievement of whole body rejuvenation.

WASHINGTON (AP) — Most Americans say it would be OK to use gene-editing technology to create babies protected against a variety of diseases — but a new poll shows they’d draw the line at changing DNA so children are born smarter, faster or taller.

A month after startling claims of the births of the world’s first gene-edited babies in China, the poll by The Associated Press-NORC Center for Public Affairs Research finds people are torn between the medical promise of a technology powerful enough to alter human heredity and concerns over whether it will be used ethically.

Jaron Keener, a 31-year-old exhibit designer at Pittsburgh’s Carnegie Museum of Natural History, said he’s opposed to “rich people being able to create designer babies.”

Replication is nature’s greatest magic trick. Watch closely, and before your very eyes you’ll see a single cell blur into two virtually identical copies. Presto.

After more than half a century of research on molecular genetics, it would be easy to assume we’ve had this biological sleight-of-hand all figured out — but it’s not the case.

Now, by applying cutting edge technology, researchers have uncovered crucial details showing how DNA times its own replication.

Continue reading “A New Study Just Solved One of The Greatest Mysteries of DNA Replication” »

China could emerge as the world’s biggest spender on research and development, after adjusting for the purchasing power of its currency, once countries publish their 2018 spending data in late 2019. Outlays on science in China have accelerated since 2003, although the country still trails behind the United States on measures of research quality. Over in Europe, officials will try to agree on how to disburse a proposed €100 billion (US$110 billion) through the European Union’s next research-funding programme, Horizon Europe, which begins in 2021. It’s unclear how fully UK researchers will be able to participate, as uncertainty over Brexit continues to plague the country.

Gene-editing, open access and a biosafety rethink are set to shape research.