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Category: genetics – Page 32

+ Decoding the secrets of DNA, CRISPR gene editing allows scientists to target specific genes linked to aging. By modifying these genes, researchers aim to prevent conditions that come with aging. Envision a future where genetic risks for age-related diseases are minimized through precise DNA editing.

It is possible to regenerate cells using stem cells, which can turn into a variety of types. In recent trials, stem cells showed promise in regenerating aged tissues like cartilage. Scientists hope to develop therapies that might slow down physical decline and maintain vitality longer by using this potential.

Nanobots could someday be the future of healthcare by targeting damaged cells directly as they move through your bloodstream. Researchers are currently exploring how nanobots might repair cellular damage and improve overall health, potentially reversing some age-related effects at the cellular level.

As the protective ends of chromosomes, telomeres shorten over time. When they become too short, cells stop functioning. In laboratory studies, researchers have extended the lifespan of animals by using telomere extension techniques. Though still experimental, this research could pave the way for human applications in slowing aging.

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Advances in human longevity are no longer science fiction. Groundbreaking discoveries in fields like genetics, nanotechnology, and regenerative medicine are unlocking the secrets of aging. These 20 developments highlight how science is changing our understanding of what it means to grow older.

Continue reading “20 Advancements That Could Push the Boundaries of the Human Lifespan” | >

Patients suffering from diseased and injured organs are often treated with transplanted organs, and this treatment has been in use for over 50 years. In 1955, the kidney became the first entire organ to be replaced in a human, when Murray transplanted this organ between identical twins. Several years later, Murray performed an allogeneic kidney transplant from a non-genetically identical patient into another. This transplant, which overcame the immunologic barrier, marked a new era in medicine and opened the door for use of transplantation as a means of therapy for different organ systems.

As modern medicine increases the human lifespan, the aging population grows, and the need for donor organs grows with it, because aging organs are generally more prone to failure. However, there is now a critical shortage of donor organs, and many patients in need of organs will die while waiting for transplants. In addition, even if an organ becomes available, rejection of organs is still a major problem in transplant patients despite improvements in the methods used for immunosuppression following the transplant procedure. Even if rejection does not occur, the need for lifelong use of immunosuppressive medications leads to a number of complications in these patients.

These problems have led physicians and scientists to look to new fields for alternatives to organ transplantation. In the 1960s, a natural evolution occurred in which researchers began to combine new devices and materials sciences with cell biology, and a new field that is now termed tissue engineering was born. As more scientists from different fields came together with the common goal of tissue replacement, the field of tissue engineering became more formally established. Tissue engineering is now defined as an interdisciplinary field which applies the principles of engineering and life sciences towards the development of biological substitutes that aim to maintain, restore or improve tissue function.

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This video provides a progress update on cutting-edge research exploring epigenetic reprogramming and small molecule cocktails for cellular rejuvenation.

Dr David Sinclair delve into the latest studies on how these approaches can potentially reverse the effects of aging at the cellular level. Topics covered include:

• The mechanisms of epigenetic reprogramming using Yamanaka factors. The development and testing of novel small molecule cocktails. Applications in various tissues and organs Research on reversing cellular senescence and restoring cell identity. The use of AI for high-throughput screening of potential rejuvenating compounds.
This update highlights recent advancements, challenges, and future directions in this exciting field of research.

* Credits to ARRD \& Dr David Sinclair*

Please note that the links below are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support!
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Columbia researchers created an AI model that predicts gene activity in any human cell, advancing disease research and treatment. It has already uncovered mechanisms behind pediatric leukemia and may reveal hidden genome functions.

Researchers at Columbia University.

Columbia University is a private Ivy League research university in New York City that was established in 1754. This makes it the oldest institution of higher education in New York and the fifth-oldest in the United States. It is often just referred to as Columbia, but its official name is Columbia University in the City of New York.

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Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make loops into DNA could move in one direction only. The discovery, which is published in Cell, is key to understanding how these motors shape our genome and regulate our genes.

“Sometimes, a cell needs to be quick in changing which genes should be expressed and which ones should be turned off, for example in response to food, alcohol or heat. To turn genes off and on, cells use Structural Maintenance of Chromosomes (SMC) motors that act like switches to connect different parts of DNA,” first author Roman Barth explains.

“However, SMC machines don’t naturally know which parts to connect. They simply load somewhere on the DNA and start shaping it into a loop until they reach a point where they are forced to stop. That’s why they rely heavily on the ability to explore both sides of the DNA to find the right stop signs.”

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Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee that each cell performs its role optimally. This is where DNA and RNA epigenetics come in: a series of mechanisms that act as “markers” on genes, to control their activity without modifying the DNA or RNA sequence itself.

Until now, DNA and RNA epigenetics were studied as independent systems. These two mechanisms seemed to function separately, each playing its own role in distinct stages of the gene regulation process.

Perhaps that was a mistake.

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As the rate of humanity’s data creation increases exponentially with the rise of AI, scientists have been interested in DNA as a way to store digital information. After all, DNA is nature’s way of storing data. It encodes genetic information and determines the blueprint of every living thing on earth.

And DNA is at least 1,000 times more compact than solid-state hard drives. To demonstrate just how compact, researchers have previously encoded all of Shakespeare’s 154 sonnets, 52 pages of Mozart’s music, and an episode of the Netflix show “Biohackers” into tiny amounts of DNA.

But these were research projects or media stunts. DNA data storage isn’t exactly mainstream yet, but it might be getting closer. Now you can buy what may be the first commercially available book written in DNA. Today, Asimov Press debuted an anthology of biotechnology essays and science fiction stories encoded in strands of DNA. For $60, you can get a physical copy of the book plus the nucleic acid version—a metal capsule filled with dried DNA.

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What is cell senescence and inflammaging?

Featuring Matt Yousefzadeh, PhD

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

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Continue reading “What Is Cell Senescence And Inflammaging? Matt Yousefzadeh, PhD” | >

Polygenic scores (PGS) are metrics used to estimate the genetic predisposition of people to developing specific mental health conditions, personality traits or diseases. In recent years, these metrics have often been used to investigate the intricate connections between genes and environmental factors.

Researchers at the JJ Peters VA Medical Center, Icahn School of Medicine at Mount Sinai and other institutes recently carried out a study aimed at determining whether neuropsychiatric could predict the professional categories that individuals belong to. Their findings, published in Nature Human Behaviour, suggest that these scores weakly predict the professional category that people belong to.

“Neuropsychiatric disorders are both common and highly heritable, yet they remain heavily stigmatized,” Georgios Voloudakis, first author of the paper, told Medical Xpress.

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Scientists develop DNADNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). tabindex=0 DNA nanorobots capable of modifying artificial cells.

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