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Category: genetics – Page 29

Neoadjuvant therapy with hedgehog inhibitors has an overall response rate (ORR) of 71%, but adverse events (AEs) like fatigue, muscle cramps, dysgeusia, and hair loss often lead to discontinuation and low compliance.

OVs represent a class of intratumoral therapeutics that might be a safe and effective neoadjuvant therapy for difficult-to-resect BCCs.

Talimogene laherparepvec (T-VEC) is an OV, a genetically engineered herpes simplex virus 1 (HSV1), approved for treating injectable, unresectable melanoma lesions in the United States and Europe. T-VEC has a dual mode of action and can alter the tumor microenvironment (TME) by activating adaptive and innate immunity.

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The data inscribed into the crystal is carefully annotated with universal elements like hydrogen, oxygen, carbon, and nitrogen, as well as the four DNA bases—adenine, cytosine, guanine, and thymine—that make up the genetic code. Additionally, the molecular structure of DNA and the arrangement of genes within chromosomes are depicted, offering clear instructions on how to interpret the genetic information stored within.

However, it is important to note that the 5D memory crystals require a highly specialized skill set and advanced equipment to inscribe and read the data stored within the crystals, so those looking to re-establish the human race after an extinction event may have to refer to more traditional means.

The crystal, made from fused quartz, is one of the most chemically and thermally resilient materials known on Earth, and can endure temperatures as high as 1000°C, resist direct impact forces up to 10 tons per square centimeter, and is unaffected by long-term exposure to cosmic radiation. The longevity and storage capacity of the 5D memory crystal earned it a Guinness World Record in 2014 for being the most durable data storage material ever created.

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A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can predict which genes are expressed in any type of human cell. The model, called EpiBERT, was inspired by BERT, a deep learning model designed to understand and generate human-like language.

The work appears in Cell Genomics.

Every cell in the body has the same , so the difference between two types of cells is not the genes in the genome, but which genes are turned on, when, and how many. Approximately 20% of the genome codes for determine which genes are turned on, but very little is known about where those codes are in the genome, what their instructions look like, or how mutations affect function in a cell.

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Discount Links/Affiliates:
At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

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NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Tracking Plasma Taurine: 13-Test Analysis” | >

Using human stem cells, they found compounds that lower cholesterol without relying on the usual pathways, providing a fresh approach to treating the condition.

A Hidden Clue in the Mona Lisa

Leonardo da Vinci’s Mona Lisa is one of the most famous paintings in the world. However, what many people don’t know is that it may also hold a clue to a medical condition called familial hypercholesterolemia (FH). Experts believe that the subtle fat deposits visible on her hands, known as xanthomas, could be early evidence of this genetic disorder.

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In today’s AI news, Block announced the launch of Goose, an open-source AI agent that allows developers to customize the tool for different purposes and using different large language models. Block’s move comes just after the Chinese startup DeepSeek unveiled its R1 artificial intelligence model, a rival to leading U.S. AI providers.

In other advancements, Cerebras and the Mayo Clinic, announcing a joint project for AI tools used in patient care. The technology was announced at the JP Morgan Healthcare Conference. In this project, the stakeholders aim to use a human reference genome to combine with patient data in order to try to identify genetic differences.

S innovative R1 reasoning model into its platform to revolutionize AI-powered search. This strategic integration strengthens Perplexity’s ability to perform deep web searches, providing users with more comprehensive and accurate results while upholding strict data security standards. + And, San Francisco-based start-up Atomicwork will today announce it has clinched $25 million of Series A financing in a round led by Khosla Ventures and Z47. The funding announcement comes less than six months after the last round, takes the total amount of money raised by the company since its launch to almost $40 million.

In videos, on this episode of Top of Mind, Gartner Global Chief of Research Chris Howard is joined by Rita Sallam, Distinguished VP Analyst, to explore how organizations can create measurable value with AI in 2025. Learn how to align investments with business priorities, manage productivity challenges and balance risk with ambition.

Ll gain a deeper knowledge of what makes a chatbot truly effective. + And, AI is transforming science in ways we never imagined. Bonnie Kruft, Deputy Director of AI for Science at Microsoft Research, shares how cutting-edge AI models are revolutionizing drug discovery, materials science, and climate prediction. Bonnie reveals how these innovations are shaping a healthier, more sustainable future for all.

S open-source model allows sharing of information, helping to lift all AI progress. He joins Caroline Hyde and Mike Shepard on “Bloomberg Technology” to discuss. ‘ + Thats all for today, but AI is moving fast — like, comment, and subscribe for more AI news! Please vote for me in the Entrepreneur of Impact Competition today! Thank you for supporting my partners and I, it’s how I keep Neural News Network free.

[](https://open.substack.com/pub/remunerationlabs/p/block-launc…hare=true)

Continue reading “Block Launches Open-Source AI Agent Goose As Jack Dorsey Praises DeepSeek’s Development Approach” | >

A leading neuroscientist claims that a pong-playing clump of about a million neurons is “sentient”. What does that mean? Why did Cortical Labs teach a lab-grown brain to play pong? To study biological self-organization at the root of life, intelligence, and consciousness. And, according to their website, “to see what happens.” What’s next for biocomputing?

CORRECTIONS/Clarifications:
- The cells aren’t directly frozen in liquid nitrogen — they are put in vials and stored in liquid nitrogen (and you can’t buy them legally without credentials) https://www.atcc.org/products/pcs-201-010
- The sentience of some invertebrates, like octopuses, is generally agreed upon. Prominent scientists affirmed non-human consciousness in the Cambridge Declaration on Consciousness: https://philiplow.foundation/consciousness/
- The “Neanderthal neurons” are human cells that are “Neanderthalized” using genetic engineering: https://www.youtube.com/watch?v=5FBxnkzI9HU

DISCLAIMER: The explanations in this video are those proposed by the researchers, or my opinion. We are far from understanding how brains, or even neurons, work. The free energy principle is one of many potential explanations.

Support the channel: https://www.patreon.com/IhmCurious.

Footage from Cortical Labs: https://www.youtube.com/watch?v=neV3aZtTgVM
NASJAQ’s interview with founder Hon Weng Chong: https://www.youtube.com/watch?v=Y1R5k5QWPsY
Cortical Labs website: https://corticallabs.com.

Full paper on DishBrain: https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6

Continue reading “Lab-Grown “Mini-Brain” Learns Pong — Is This Biological Neural Network “Sentient”?” | >

NAD, a vital molecule for cellular energy and DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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The divide between their lineage and ours narrowed even further in 2010, when researchers published the first Neandertal genome sequence. Comparison of that ancient DNA with modern human DNA showed that the two species had interbred and that people today still carry the genetic fingerprint of that intermixing. Since then, numerous studies have explored the ways in which Neandertal DNA affects our modern physiology, revolutionizing our understanding not only of our extinct cousins but of ourselves as a hybrid species.

This area of research, clinical paleogenomics, is still in its infancy, and there are many complexities to unravel as we explore this new frontier. We therefore must take the findings from these studies with a grain of salt. Nevertheless, the research conducted to date raises the fascinating possibility that Neandertal DNA has wide-­reach­ing effects on our species—not only on general health but on brain development, including our propensity for conditions such as autism. In other words, DNA from our extinct relatives may, to some extent, shape the cognition of people today.

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A study has introduced a novel bioprocess that transforms CO2 and electricity into single-cell protein (SCP), a sustainable food source rich in essential amino acids.

<div class=””> <div class=””><br />Amino acids are a set of organic compounds used to build proteins. There are about 500 naturally occurring known amino acids, though only 20 appear in the genetic code. Proteins consist of one or more chains of amino acids called polypeptides. The sequence of the amino acid chain causes the polypeptide to fold into a shape that is biologically active. The amino acid sequences of proteins are encoded in the genes. Nine proteinogenic amino acids are called “essential” for humans because they cannot be produced from other compounds by the human body and so must be taken in as food.<br /></div> </div>

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